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Pathophysiology of Shock, Sepsis, and Organ Failure pp 665–675Cite as

Experimentally Induced DIC — DIC as a Cause of MOF

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Abstract

Gram-negative septicemia remains a serious cause of mortality (Carrico et al. 1986) and is often associated with disseminated intravascular coagulation (DIC) (Effeney et al. 1978; Siegal et al. 1978; Spero et al. 1980; Edgington 1990; Linares 1990). Autopsy revealed sepsis and DIC in 74% of burn patients, while multiorgan failure (MOF) and DIC were encountered in 95% (Linares 1990), indicating a major role of DIC in the development of MOE DIC is a pathophysiological syndrome induced by trauma, endotoxemia, and especially septic shock. Changes in the clotting and complement system, activation of the fibrinolytic system and reduction of platelet counts during both gram-negative sepsis in humans and experimental endotoxin shock in other species are characteristics of DIC (Aasen et al. 1978 a, b, c; Garner and Evensen 1974; Garner et al. 1974; Hamilton et al. 1978; Müller-Berghaus 1975).

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  1. Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Donaueschingenstraße 13, A-1200, Vienna, Austria

    S. Bahrami & G. Schlag

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  1. S. Bahrami
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  1. Ludwig-Boltzmann Institute for Experimental and Clinical Traumatology, Donaueschingenstraße 13, A-1200, Vienna, Austria

    Günther Schlag M. D.  & Heinz Redl Ph. D.  & 

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© 1993 Springer-Verlag Berlin Heidelberg

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Bahrami, S., Schlag, G. (1993). Experimentally Induced DIC — DIC as a Cause of MOF. In: Schlag, G., Redl, H. (eds) Pathophysiology of Shock, Sepsis, and Organ Failure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76736-4_46

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  • DOI: https://doi.org/10.1007/978-3-642-76736-4_46

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