Abstract
The bactericidal effect of blood has been known for more than 100 years [1, 2]. As early as the late nineteenth century it was demonstrated that serum contains factors that mediate lysis of bacteria and antibody sensitized cells [3]. Complement is an essential system for protection against invading microorganisms like virus and bacteria. Split products of this cascade will enhance phagocytosis, bacterial killing and promote leukocytosis [4, 5]. Lysis of foreign invaders by complement requires components C5b-C9 from the terminal part of the complement cascade. This complex is also called the membrane attack complex [6]. Individuals with different hereditary complement protein defects suffer from recurrent and sometimes life threatening infections [7–9].
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Heideman, M., Bengtsson, A. (1993). The Role of Complement. In: Schlag, G., Redl, H. (eds) Pathophysiology of Shock, Sepsis, and Organ Failure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76736-4_3
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