Summary
To investigate the influence of race on the cellular immune system, we analyzed peripheral blood mononuclear cell subsets in 266 healthy nonsmoking adults and 112 healthy children. Among adults, blacks had a significantly higher proportion of B cells, a lower proportion of T cells, and a higher proportion of HLA-DR positive cells and activated T cells than whites. Among children, the proportion of HLA-DR positive cells and activated T cells were significantly higher in blacks than in whites, but the proportion of T cells and B cells were similar in blacks and whites. An apparent decrease in the proportion of CD4+ (T-Helper) cells was observed in black women age 50 and older compared to white women and younger black women. These and other race-related immunologic alterations may provide clues to the etiology of diseases and conditions which exhibit significant racial differences.
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© 1991 Springer-Verlag Berlin Heidelberg
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Tollerud, D.J., Brown, L.M., Blattner, W.A., Hoover, R.N. (1991). The Influence of Race on T-Cell Subset Distributions. In: Obrams, G.I., Potter, M. (eds) Epidemiology and Biology of Multiple Myeloma. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76655-8_8
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DOI: https://doi.org/10.1007/978-3-642-76655-8_8
Publisher Name: Springer, Berlin, Heidelberg
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