Abstract
Platelet interactions with vessel wall are certainly important in the pathophysiology of myocardial ischemia [1]. Interventions that reduce platelet reactivity (adhesion, aggregation, release/secretion) have been performed in the last two decades for several clinical forms of ischemic heart disease. This brief review will deal only with aspirin, which is the antiplatelet drug more and better studied in this context, and is still the most used in clinical practice [2].
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References
Mruk JS, Chesebro JH, Webster MWI (1990) Platelet aggregation and interaction with the coagulation system: implications for antithrombotic therapy in arterial thrombosis. Coronary Artery Dis 1: 149–158
Hennekens CH, Buring JE, Sandercock P, Collins R, Peto R (1989) Aspirin and other antiplatelet agents in the secondary and primary prevention of cardiovascular disease. Circulation 80: 749–756
Stein B, Fuster V, Halperin JL, Chesebro JH (1989) Antithrombotic therapy in cardiac disease. An emerging approach based on pathogenesis and risk. Circulation 80: 1501–1513
Steering Committee of the Physicians’ Health Study Research Group (1989) Final report on the aspirin component of the ongoing Physicians’ Health Study. N Engl J Med 321: 129–135
Peto R, Gray R, Collins R et al. (1988) Randomized trial of prophylactic daily aspirin in British male doctors. Br Med J 296: 313–316
Hennekens CH, Peto R, Hutchison GB, Doll R (1988) An overview of the British and American aspirin studies. N Engl J Med 318: 923–924
Antiplatelet Trialists’ Collaboration (1988) Secondary prevention of vascular disease by prolonged antiplatelet treatment. Br Med J 296: 320–331
Buring JE, Hennekens CH (1990) Antiplatelet therapy to prevent coronary artery bypass graft occlusion. Circulation 82: 1046–1048
Schwartz L, Bourassa MG, Lespérance J et al. (1988) Aspirin and dipyridamole in the prevention of restenosis after percutaneous transluminal coronary angioplasty. N Engl J Med 318: 1714–1719
Ridker PM, Manson JOE, Gaziano JM, Buring JE, Hennekens CH (1990) Low dose aspirin therapy for chronic stable angina. Circulation 82 [Suppl III]: III-200 (abstr)
Chesebro JH, Webster MWI, Smith HC et al. (1989) Antiplatelet therapy in coronary disease progression: reduced infarction and new lesion formation. Circulation 80 [Suppl II]: 11–266 (abstr)
Julian DG (1990) Secondary prevention after myocardial infarction. In: Jackson G (ed) Difficult cardiology. Practical management and decision-making, Dunitz, London, pp 119–129
Cairns JA, Gent M, Singer J et al. (1985) Aspirin, sulfinpyrazone or both in unstable angina: results of a Canadian multicentre trial. N Engl J Med 313: 1369–1375
Lewis HD, Davis JW, Archibald DG et al. (1983) Protective effects of aspirin against acute myocardial infarction and death in men with unstable angina: results of a Veterans Administration Cooperative Study. N Engl J Med 309: 396–403
Théroux P, Ouilmet H, McCans J et al. (1988) Aspirin, heparin or both to treat acute unstable angina. N Engl J Med 319: 1105–1111
The RISK Group (1990) Risk of myocardial infarction and death during treatment with low dose aspirin and intravenous heparin in men with unstable coronary artery disease. Lancet 336: 827–830
ISIS-2 Collaborative Group (1988) Randomized trial of intravenous streptokinase, oral aspirin, both, or neither among 17 187 cases of suspected acute myocardial infarction: ISIS-2. Lancet ii: 349–360
Hirsh J, Salzman EW, Harker L et al. (1989) Aspirin and other platelet active drugs. Relationship among dose, effectiveness, and side effects. Chest 95 [Suppl]: 12S–16S
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© 1992 Springer-Verlag Berlin Heidelberg
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Geraci, E. (1992). Antiplatelet Therapy and Prevention of Myocardial Ischemia. In: Di Pasquale, G., Pinelli, G. (eds) Heart-Brain Interactions. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76652-7_18
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DOI: https://doi.org/10.1007/978-3-642-76652-7_18
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