Abstract
It is a great pleasure and honor for me to speak on the use of polyclonal antilymphocyte serum and donor antigen, specifically donor-specific bone marrow, to produce specific unresponsiveness (tolerance) to allografted tissue and organs. This topic is especially significant in view of Prof. Walter Brendel’s early and pioneering interests in the uses of polyclonal antilymphocyte sera in tissue transplantation. This presentation is taken from a recent summary [1] by my colleagues and me in which we updated the use of polyclonal antilymphocyte serum and donor-specific bone marrow to induce unresponsiveness to tissue and organ allografts in several species.
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References
Monaco AP, Wood ML, Maki T, Gozzo JJ (1989) Future strategies in immunosuppression: Problems and potential for the induction of specific unresponsiveness to organ allografts in clinical transplantation. Transplant Proc 21: 3939
Billingham RE, Brent L, Medawar PB (1953) Actively acquired tolerance to foreign cells. Nature 172: 603
Monaco AP (1988) Biological immunosuppression: Polyclonal antilymphocyte sera, monoclonal antibody and donor specific antigen. In: GJ Cerilli (ed), Organ transplantation and replacement. Lippincott, Philadelphia, p 83
Monaco AP, Wood ML, Maki T, Hartner W, De Fazio S, Gozzo JJ (1988) Cyclosporine and unresponsiveness to allografts induced by polyclonal ALS and donor specific bone marrow. Transplant Proc 20: 36
Monaco AP, Wood ML, Maki T, Gozzo JJ, De Fazio S (1988) The use of donor specific antigen for the induction of immunological unresponsiveness to experimental and clinical allografts. Transplant Proc 20: 122
Wood ML, Gottschalk R, Monaco AP (1988) The effect of cyclosporine on the induction of unresponsiveness in ALS-treated, marrow injected mice. Transplantation 46: 449
Thomas JM, Carver M, Cunningham P, Park K, Gonder J, Thomas F (1987) Promotion of incompatible allograft acceptance in rhesus monkeys given post-transplant ATG and donor bone marrow. I. In vivo parameters and immunohistologic evidence suggesting microchimerism. Transplantation 43: 332
Caddis T, Liegeois A, Barrett I, Monaco AP (1973) Enhanced survival of canine renal allografts in ALS treated dogs given bone marrow. Transplant Proc 5: 671
Hartner WC, De Fazio S, Maki T, Markees TG, Monaco AP, Gozzo JJ (1986) Prolongation of renal allograft survival in ALS treated dogs by postoperative injection of density gradient fractionated donor bone marrow. Transplantation 42: 593
Thomas JM, Carver M, Foil MB et al. (1983) Long term incompatible kidney survival in outbred higher primates without chronic immunosuppression. Ann Surg 198: 370
Thomas JM, Carver M, Cunningham P, Sash C, Park K, Thomas F (1989) Promotion of incompatible allograft acceptance in rhesus monkeys given post-transplant ATG and donor bone marrow. II. Effect of adjuvant immunosuppressive drugs. Transplantation 47: 209
Monaco AP, Wood ML, Maki T, Madras PN, Sahyoun AI, Simpson MA (1985) Attempt to induce unresponsiveness to human renal allografts with ALG and donor specific bone marrow. Transplant Proc 17: 1312
Barber WH, Diethelm AG, Laskow DA, Deierhoi MA, Julian BA, Curtis JJ (1989) Use of cryopreserved donor bone marrow in cadaver kidney allograft recipients. Transplantation 47: 66
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© 1991 Springer-Verlag Berlin · Heidelberg
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Monaco, A.P. (1991). The Use of Donor-Specific Bone Marrow to Induce Specific Allograft Unresponsiveness (Tolerance) in Adult Animals Transiently Immunosuppressed with Polyclonal Antilymphocyte Serum. In: Messmer, K., Stein, M. (eds) Pathways in Applied Immunology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76606-0_9
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DOI: https://doi.org/10.1007/978-3-642-76606-0_9
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