Skip to main content
SpringerLink
Log in

In Vitro Drug Resistance in Childhood Acute Lymphoblastic Leukemia in Relation to Age and Immunophenotype

  • Conference paper
Acute Leukemias

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 34))

Abstract

The immunophenotype is one of the prognostic factors in children with acute lymphoblastic leukemia (ALL) [1–6]. B-ALL cases have the worst prognosis and patients with B-cell precursor ALL the most favorable prognosis. Among the patients with precursor B-ALL, those whose lymphoblasts have cytoplasmic.t heavy chain (cµ; preB ALL) and the small group of patients whose cells lack the common ALL (cALL) antigen characteristic of the earliest stage of B-cell differentiation (proB ALL) show poorer responses by comparison with the cALL+/cµ− cases (cALL). Also patients with T-ALL have an unfavorable prognosis. Part of these findings are still controversial because in some studies the immunophenotype is related to other clinical and biological features like white blood cell count (WBC) and organomegaly. Also, when effective treatments are used, the prognostic value of immunophenotype could be diminished [7–9].

This study is supported by the Dutch Cancer Society (IKA87–17 and 89–06).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Crist WM, Grossi CE, Pullen J, Cooper M (1985) Immunologic markers in childhood acute lymphocytic leukemia. Semin Oncol 12: 105

    PubMed  CAS  Google Scholar 

  2. Sallan SE, Ritz J, Pesando J, Gelber R, O’Brien C, Hithcock S, Coral F, Schlossman SF (1980) Cell surface antigens: prognostic implications in childhood acute lymphoblastic leukemia. Blood 55: 395

    PubMed  CAS  Google Scholar 

  3. Greaves MF, Janossy G, Peto J, Kay H (1981) Immunologically defined subclasses of acute lymphoblastic leukemia in children: their relationship to presentation features and prognosis. Br J Haematol 48: 179

    PubMed  CAS  Google Scholar 

  4. Pui CH, Williams DL, Raimondi SC, Melvin SL, Behm FG, Look AT, Dahl GV, Rivera GK, Kalwinsky DK, Mirro J, Dodge RK, Murphy SB (1986) Unfavorable presenting clinical and laboratory features are associated with calla-negative non T, non-B lymphoblastic leukemia in children. Leuk Res 10: 1287

    Article  PubMed  CAS  Google Scholar 

  5. Crist W, Boyett J, Roper M, Pullen J, Metz-gar R, van Eys J, Ragab A, Starling K,Vietti T, Cooper M (1984) Pre-B cell leukemia responds poorly to treatment: a Pediatric Oncology Group study. Blood 63: 407

    CAS  Google Scholar 

  6. Crist W, Boyett J, Jackson J, Vietti T, Borowitz M, Chauvenet A, Winick N, Ragab A, Mahoney D, Head D, Iyer R, Wagner H, Pullen J (1989) Prognostic importance of the pre-B-cell immunophenotype and other presenting features in B-lineage childhood acute lymphoblastic leukemia: a Pediatric Oncology Group study. Blood 74: 1252

    PubMed  CAS  Google Scholar 

  7. Borowitz MJ (1990) Immunologic markers in childhood acute lymphoblastic leukemia. Hematol Oncol Clin North Am 4: 743

    PubMed  CAS  Google Scholar 

  8. Poplack DG, Reaman G (1988) Acute lymphoblastic leukemia in childhood. Pediatr Clin North Am 35: 903

    PubMed  CAS  Google Scholar 

  9. Miller DR (1988) Childhood acute lymphoblastic leukemia: 1. Biological features and their use in predicting outcome of treatment. Am J Pediatr Hematol Oncol 10: 163

    Article  Google Scholar 

  10. Reaman G, Zeltzer P, Bleyer A, Amendola B, Level C, Sather H, Hammond D (1985) Acute lymphoblastic leukemia in infants less than one year of age: a cumulative experience of the Childrens Cancer Study Group. J Clin Oncol 3: 1513

    PubMed  CAS  Google Scholar 

  11. Hammond D, Sather H, Nesbit M, Miller D, Coccoa P, Bleyer A, Lukens J, Siegel S (1986) Analysis of prognostic factors in acute lymphoblastic leukemia. Med Pediatr Oncol 14: 124

    Article  PubMed  CAS  Google Scholar 

  12. Crist W, Pullen J, Boyett J, Falletta J, van Eys J, Borowitz M, Jackson J, Dowell B, Frankel L, Quddus F, Ragab A, Vietti T (1986) Clinical and biologic features predict a poor prognosis in acute lymphoid leukemias in infants: a Pediatric Oncology Group study. Blood 67: 135

    PubMed  CAS  Google Scholar 

  13. Crist W, Boyett J, Pullen J, van Eys J,Vietti T (1986) Clinical and biologic features predict poor prognosis in acute lymphoid leukemias in children and adolescents: a Pediatric Oncology Group review. Med Pediatr Oncol 14: 135

    CAS  Google Scholar 

  14. Pui C-H, Williams DL, Roberson PK, Raimondi SC, Behm FG, Lewis SH, Rivera GK, Kalwinsky DK, Abromowitch M, Crist WM, Murphy SB (1988) Correlation of karyotype and immunophenotype in childhood acute lymphoblastic leukemia. J Clin Oncol 6: 56

    PubMed  CAS  Google Scholar 

  15. Pieters R, Huismans DR, Leyva A,Veerman AJP (1988) Adaptation of a rapid automated tetrazolium based ( MTT-)assay for chemo sensitivity testing in childhood leukemia. Cancer Lett 41: 323

    Google Scholar 

  16. Pieters R, Huismans DR, Leyva A,Veerman AJP (1989) Comparison of a rapid auto mated tetrazolium based ( MTT-)assay with a dye exclusion assay for chemosensitivity testing in childhood leukemia. Br J Cancer 59: 217

    Google Scholar 

  17. Pieters R, Loonen AH, Huismans DR, Broekema GJ, Dirven MWJ, Heyenbrok MW, Hählen K,Veerman AJP (1990) In vitro drug sensitivity of cells from children with leukemia using the MTTassay with improved culture conditions. Blood 76: 2327

    Google Scholar 

  18. Santini V, Bernabei PA, Silvestro L, Dal Pozzo O, Bezzini R, Viano I, Gattei V, Saccardi R, Rossi Ferrini P (1989) In vitro chemosensitivity testing of leukemic cells: prediction of response to chemotherapy in patients with acute non-lymphocytic leukemia. Haematol Oncol 7: 287

    Article  CAS  Google Scholar 

  19. Sargent JM, Taylor CG (1989) Appraisal of the MTT assay as a rapid test of chemosensitivity in acute myeloid leukaemia. Br J Cancer 60: 206

    Article  PubMed  CAS  Google Scholar 

  20. Hongo T, Fujii Y, Igarashi Y (1990) An in vitro chemosensitivity test for the screening of anti-cancer drugs in childhood leukemia. Cancer 65: 1263

    Article  PubMed  CAS  Google Scholar 

  21. Veerman AJP, Pieters R (1990) Drug sensi tivity assays in leukemia and lymphoma. Br J Haematol 74: 381

    Article  PubMed  CAS  Google Scholar 

  22. Pieters R (1991) Drug resistance in child-hood leukemia. Thesis, Free University, Amsterdam

    Google Scholar 

  23. Arseneau JC, Canellos GP, Banks PM, Berard CW, Gralnick HR, DeVita BT (1975) American Burkitt’s lymphoma: a clinicopa-thologic study of 30 cases. I. Clinical factors relating to prolonged survival. Am J Med 58: 314

    Google Scholar 

  24. Costlow ME, Pui C-H, Dahl GV (1982) Glucocorticoid receptors in childhood acute lymphocytic leukemia. Cancer Res 42: 4801

    PubMed  CAS  Google Scholar 

  25. Quddus FF, Leventhal BG, Boyett JM, Pullen DJ, Crist WM, Borowitz MJ (1985) Glucocorticoid receptors in immunological subtypes of childhood acute lymphocytic leukemia: a Pediatric Oncology Group study. Cancer Res 45: 6482

    PubMed  CAS  Google Scholar 

  26. Vogler LB, Crist WM, Sarrif AM, Pullen J, Bartolucci AA, Falletta JM, Dowell B, Humphrey GB, Blackstock R, van Eys J, Metzgar RS, Cooper MD (1981) An analysis of clinical and laboratory features of acute lymphocytic leukemias with emphasis on 35 children with pre-B leukemia. Blood 58: 135

    PubMed  CAS  Google Scholar 

  27. Pui C-H, Dahl GV, Rivera G, Murphy SB, Costlow ME (1984) The relationship of blast cell glucocorticoid receptor levels to response to single-agent steroid trial and remission response in children with acute lymphoblastic leukemia. Leuk Res 8: 579

    Article  PubMed  CAS  Google Scholar 

  28. Mastrangelo R, Malandrino R, Riccardi R, Longo O, Ranelletti FO, Iacobelli S (1980) Clinical implications of glucocorticoid recep-tor studies in childhood acute lymphoblastic leukemia. Blood 56: 1036

    PubMed  CAS  Google Scholar 

  29. Pui C-H, Costlow ME (1986) Sequential studies of lymphoblast glucocorticoid recep-tor levels at diagnosis and relapse in childhood leukemia: an update. Leuk Res 10: 227

    Article  PubMed  CAS  Google Scholar 

  30. Thompson EB, Smith JR, Bourgeois S, Harmon JM (1985) Glucocorticoid receptors in human leukemias and related diseases. Klin Wochenschr 63: 689

    Article  PubMed  CAS  Google Scholar 

  31. Thompson EB, Harmon JM (1986) Gluco- corticoid receptors and glucocorticoid resistance in human leukemia in vivo and in vitro. Adv Exp Med Biol 196: 111

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, Free University Hospital, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands

    R. Pieters, G. J. L. Kaspers, D. R. Huismans, A. H. Loonen & A. J. P. Veerman

  2. Dutch Childhood Leukemia Study Group, The Hague, The Netherlands

    E. R. van Wering, K. Hählen & A. J. P. Veerman

  3. Sophia’s Children Hospital, Subdivision Haemato/Oncology, Erasmus University, Rotterdam, The Netherlands

    K. Hählen

Authors
  1. R. Pieters
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. J. L. Kaspers
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. R. van Wering
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. D. R. Huismans
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. H. Loonen
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. K. Hählen
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. A. J. P. Veerman
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Internal Medicine, University of Münster, Albert-Schweitzer-Straße 33, D-4400, Münster, Federal Republic of Germany

    W. Hiddemann , T. Büchner  & B. Wörmann ,  & 

  2. M. D. Anderson Cancer Center, University of Texas, 1515 Holocombe Boulevard, 77030, Houston, TX, USA

    W. Plunkett , M. Keating  & M. Andreeff ,  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Pieters, R. et al. (1992). In Vitro Drug Resistance in Childhood Acute Lymphoblastic Leukemia in Relation to Age and Immunophenotype. In: Hiddemann, W., Büchner, T., Wörmann, B., Plunkett, W., Keating, M., Andreeff, M. (eds) Acute Leukemias. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 34. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76591-9_50

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-76591-9_50

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53949-0

  • Online ISBN: 978-3-642-76591-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation