Abstract
The maturation and differentiation pathway of normal bone marrow cells can be followed by monoclonal antibodies. Using five-dimensional flow cytometry (forward and side scatter, and three immunofluorescence signals) normal cell maturation is characterized by gradual changes of light-scattering properties and by gradual loss or acquisition of specific cell surface antigens [1–4]. Leukemic blasts can be distinguished from normal bone marrow cells by aberrant expression of surface antigens, e.g., abnormal quantitative expression and coexpression of cell surface antigens not occurring during normal maturation [5–7].
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© 1992 Springer-Verlag Berlin Heidelberg
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Zurlutter, K. et al. (1992). Detection of Residual Leukemic Cells in the Majority of AML Patients After the Administration of TAD9. In: Hiddemann, W., Büchner, T., Wörmann, B., Plunkett, W., Keating, M., Andreeff, M. (eds) Acute Leukemias. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 34. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76591-9_30
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DOI: https://doi.org/10.1007/978-3-642-76591-9_30
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-53949-0
Online ISBN: 978-3-642-76591-9
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