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Detection of Residual Leukemic Cells in AML

  • Conference paper
Acute Leukemias

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 34))

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Abstract

Sixty to seventy percent of adult patients with newly diagnosed AML can achieve a complete remission (CR) through intensive chemotherapy [1–6]. However, the majority of these patients will suffer relapse within 2 years. With the exception of age, secondary leukemias, and a small group of cytogenetically defined AML, no universelly accepted prognostic marker has been identified which would allow early treatment stratification. Thus AML treatment is highly uniform, consisting of intensive induction chemotherapy, followed by consolidating postremission therapy with or without bone marrow transplantation. The “gold standard” for the diagnosis of AML and therapy monitoring is the light microscopic evaluation of cytology and cytochemistry. Its sensitivity for the detection of residual leukemic cells is 5%.

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Authors and Affiliations

  1. University of Münster, Department of Internal Medicine A, University of Münster, Albert-Schweitzer Str. 33, 4400, Münster, Germany

    B. Wörmann, S. Könemann, A. Humpe, K. Zurlutter, K. Schreiber, K. Piechotka, Th. Büchner & W. Hiddemann

  2. Becton Dickinson Immunocytometry Systems, San José, CA, USA

    M. Safford & L. W. M. M. Terstappen

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  1. B. Wörmann
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  2. S. Könemann
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  3. A. Humpe
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  4. M. Safford
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  5. K. Zurlutter
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  6. K. Schreiber
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  7. K. Piechotka
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  8. Th. Büchner
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  9. W. Hiddemann
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Editors and Affiliations

  1. Department of Internal Medicine, University of Münster, Albert-Schweitzer-Straße 33, D-4400, Münster, Federal Republic of Germany

    W. Hiddemann , T. Büchner  & B. Wörmann ,  & 

  2. M. D. Anderson Cancer Center, University of Texas, 1515 Holocombe Boulevard, 77030, Houston, TX, USA

    W. Plunkett , M. Keating  & M. Andreeff ,  & 

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© 1992 Springer-Verlag Berlin Heidelberg

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Wörmann, B. et al. (1992). Detection of Residual Leukemic Cells in AML. In: Hiddemann, W., Büchner, T., Wörmann, B., Plunkett, W., Keating, M., Andreeff, M. (eds) Acute Leukemias. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 34. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76591-9_29

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  • DOI: https://doi.org/10.1007/978-3-642-76591-9_29

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53949-0

  • Online ISBN: 978-3-642-76591-9

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