Regulation of Erythropoietin Production in Patients with Myelodysplastic Syndromes

  • C. Aul
  • A. Heyll
  • V. Runde
  • M. Arning
  • W. Schneider
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 34)


Preleukemic syndromes or myelodysplastic syndromes (MDS) comprise a heterogeneous group of acquired bone marrow disorders, probably resulting from malignant transformation of a multipotent hematopoietic stem cell [1, 2]. In the elderly they are rather common diseases. Analysis of our own data referring to the population of Düsseldorf (Germany) yields an age-specific incidence rate of about 25/100 per year in people over the age of 70 [3]. Hallmarks of MDS include ineffective hematopoiesis, hypercellular bone marrow, and peripheral blood cytopenias [4]. In the majority of cases the etiology remains unkown.


Myelodysplastic Syndrome Prussian Blue Mean Corpuscular Volume Refractory Anemia Serum Erythropoietin 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • C. Aul
    • 1
  • A. Heyll
    • 1
  • V. Runde
    • 1
  • M. Arning
    • 1
  • W. Schneider
    • 1
  1. 1.Department of Internal Medicine, Hematology and Oncology DivisionHeinrich Heine UniversityDüsseldorfGermany

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