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Proliferation — Inducing Effects of Recombinant Human Interleukin-7 and Interleukin-3 in B-Lineage Acute Lymphoblastic Leukemia

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Acute Leukemias

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 34))

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Abstract

Acute lymphoblastic leukemia (ALL) is a clonal disorder characterized by derangements of self-renewal and differentiation of lymphoid precursor cells in the bone marrow. Corresponding to the inconsistent stimulatory effects of the recombinant hematopoietic growth factors studied to date on B-lineage ALL blasts in vitro [1], a reproducible culture assay that supports proliferation and maturation of ALL blasts has not yet been reported.

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Author information

Authors and Affiliations

  1. Department of Hematology, University of Frankfurt, Frankfurt, Germany

    D. Hoelzer

  2. Department of Pediatrics II, Molecular Biology Section, University of Ulm, Ulm, Germany

    A. Ganser, M. Eder, O. G. Ottmann, T. E. Hansen-Hagge & C. R. Bartram

  3. Immunex Corporation, Seattle, Washington, USA

    S. Gillis

Authors
  1. A. Ganser
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  2. M. Eder
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  3. O. G. Ottmann
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  4. T. E. Hansen-Hagge
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  5. C. R. Bartram
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  6. S. Gillis
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  7. D. Hoelzer
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Editor information

Editors and Affiliations

  1. Department of Internal Medicine, University of Münster, Albert-Schweitzer-Straße 33, D-4400, Münster, Federal Republic of Germany

    W. Hiddemann , T. Büchner  & B. Wörmann ,  & 

  2. M. D. Anderson Cancer Center, University of Texas, 1515 Holocombe Boulevard, 77030, Houston, TX, USA

    W. Plunkett , M. Keating  & M. Andreeff ,  & 

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© 1992 Springer-Verlag Berlin Heidelberg

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Ganser, A. et al. (1992). Proliferation — Inducing Effects of Recombinant Human Interleukin-7 and Interleukin-3 in B-Lineage Acute Lymphoblastic Leukemia. In: Hiddemann, W., Büchner, T., Wörmann, B., Plunkett, W., Keating, M., Andreeff, M. (eds) Acute Leukemias. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 34. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76591-9_21

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  • DOI: https://doi.org/10.1007/978-3-642-76591-9_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53949-0

  • Online ISBN: 978-3-642-76591-9

  • eBook Packages: Springer Book Archive

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