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Acute Leukemias pp 56–59Cite as

Cytostatic Drug Resistance and Differentiation in Friend Erythroleukemia Cells

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Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 34))

Abstract

Cytostatic drug resistance is a common clinical problem in antitumor chemotherapy. To study mechanisms of drug resistance, in vitro model systems have been established. Frequently cross-resistance to other cytostatic drugs (i.e., chemically and structurally not related to the selective agent) was observed in these cell lines [1]. Multidrug resistance included medicaments often used in clinical therapy regimens such as vinca alkaloids or anthracyclines. Over-expression of a 170 kD glycoprotein was found to correlate with the multidrugresistant phenotype [2, 3]. The gene encoding for the 170 kD glycoprotein, mdrl, has been cloned and sequenced [4, 5]. The multidrug-resistant phenotype could be transferred to drug-sensitive cells by transfection with mdrl cDNA [6, 7]. Resistant cells showed significant lower intracellular cytostatic drug levels, due to an activated drug efflux mechanism [8, 9]. MDR gene overexpression was detected in several leukemias and tumors and could be related to poor prognosis [10–13].

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Author information

Authors and Affiliations

  1. Universitätsklinikum Rudolf Virchow, Abtlg Innere Medizin, Freie Universität Berlin, Spandauer Damm 130, Berlin, Germany

    C. A. Schmidt, F. Lorenz, H. Oettle, F. F. Wilborn, D. Huhn & W. Siegert

  2. Abtlg Toxikologie, Universität Hamburg, Grindelallee 117, Hamburg, Germany

    A. Schäfer

Authors
  1. C. A. Schmidt
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  2. A. Schäfer
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  3. F. Lorenz
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  4. H. Oettle
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  5. F. F. Wilborn
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  6. D. Huhn
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  7. W. Siegert
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Editor information

Editors and Affiliations

  1. Department of Internal Medicine, University of Münster, Albert-Schweitzer-Straße 33, D-4400, Münster, Federal Republic of Germany

    W. Hiddemann , T. Büchner  & B. Wörmann ,  & 

  2. M. D. Anderson Cancer Center, University of Texas, 1515 Holocombe Boulevard, 77030, Houston, TX, USA

    W. Plunkett , M. Keating  & M. Andreeff ,  & 

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© 1992 Springer-Verlag Berlin Heidelberg

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Schmidt, C.A. et al. (1992). Cytostatic Drug Resistance and Differentiation in Friend Erythroleukemia Cells. In: Hiddemann, W., Büchner, T., Wörmann, B., Plunkett, W., Keating, M., Andreeff, M. (eds) Acute Leukemias. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 34. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76591-9_10

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  • DOI: https://doi.org/10.1007/978-3-642-76591-9_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53949-0

  • Online ISBN: 978-3-642-76591-9

  • eBook Packages: Springer Book Archive

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