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Multidrug Resistance and Its Circumvention in Acute Leukemia

  • Conference paper
Book cover Acute Leukemias

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 34))

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Abstract

The use of intensive chemotherapy regimens produces complete remissions in up to 90% of children with acute lymphocytic leukemia, and more than half of these patients are expected to be cured of their disease [1]. Among patients with acute myeloid leukemia (AML) and adults with acute lymphocytic leukemia, sustained complete remissions are achieved in only 20%–40% of cases [2, 3]. Remission rates in patients relapsing from a complete remission are substantially lower due to development of resistance to agents employed in primary therapy and other agents to which the patient has not been exposed. In experimental systems, resistance to multiple agents most often relates to expression of P-glycoprotein, or the multidrug resistance (MDR) phenotype. In this chapter we review the role of MDR in acute leukemia and current clinical trials at the Arizona Cancer Center aimed a-restoring chemosensitivity in these disorders.

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Author information

Authors and Affiliations

  1. Section of Hematology/Oncology, Department of Internal Medicine and Department of Pathology, University of Arizona College of Medicine, Tucson, Arizona, USA

    A. F. List, C. M. Spier & W. S. Dalton

Authors
  1. A. F. List
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  2. C. M. Spier
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  3. W. S. Dalton
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Editor information

Editors and Affiliations

  1. Department of Internal Medicine, University of Münster, Albert-Schweitzer-Straße 33, D-4400, Münster, Federal Republic of Germany

    W. Hiddemann , T. Büchner  & B. Wörmann ,  & 

  2. M. D. Anderson Cancer Center, University of Texas, 1515 Holocombe Boulevard, 77030, Houston, TX, USA

    W. Plunkett , M. Keating  & M. Andreeff ,  & 

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© 1992 Springer-Verlag Berlin Heidelberg

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List, A.F., Spier, C.M., Dalton, W.S. (1992). Multidrug Resistance and Its Circumvention in Acute Leukemia. In: Hiddemann, W., Büchner, T., Wörmann, B., Plunkett, W., Keating, M., Andreeff, M. (eds) Acute Leukemias. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 34. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76591-9_1

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  • DOI: https://doi.org/10.1007/978-3-642-76591-9_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53949-0

  • Online ISBN: 978-3-642-76591-9

  • eBook Packages: Springer Book Archive

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