Abstract
Rodents with atrial thrombosis can be recognized at necropsy. The left atrium is swollen, firm, and mottled white and red. Other associated lesions in hamsters include pulmonary edema and pleural effusion. Mice with atrial thrombosis have a dilated left atrium that is firm with irregular gray areas. The wall of the thrombosed atrium is stretched and thin (Fry et al. 1965; Frith et al. 1983). In cut section, a single thrombus or multiple thrombi fill most of the atrial lumen and may project into the mitral opening. The site and extent of attachment of the thrombus to the atrial wall varies from animal to animal. The exposed thrombus is gray to tan and may be laminated. Recently formed thrombi are firm and inelastic and gray-red (Wilens and Sproul 1938). Rupture of the distended atrium with hemorrhage into the pericardial and pleural cavities occurs, but is rare.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ball CR, Williams WL (1965) Spontaneous and dietary- induced cardiovascular lesions in DBA mice. Anat Rec 152: 199–210
Ball CR, Clower BR, Williams WL (1965) Dietary-induced atrial thrombosis in mice. Arch Pathol 80: 391–396
Burek JD (1978) Cardiovascular system. In: Pathology of aging rats. CRC, Boca Raton, pp 75–94
Dodds WJ, Raymond SL, Moynihan AC, McMartin DN (1977) Spontaneous atrial thrombosis in aged Syrian hamsters. II. Hemostasis. Thromb Hemostas 38: 457– 464
Farris EJ, Yeakel EH, Seitner MM (1946) Ossifying cartilage and thrombi in the hearts of rats. Am J Pathol 22: 613–616
Frith CH, Highman B, Burger G, Sheldon WD (1983) Spontaneous lesions in virgin and retired breeder BALB/c and C57BL/6 mice. Lab Anim Sci 33: 273– 286
Fry RJM, Hamilton KH, Lisco H (1965) Thrombi in the left atrium of the heart in mice. Arch Pathol 80: 308– 313
Homburger F, Russfield AB, Weisburger JH, Lim S, Chak SP, Weisburger EK (1975) Aging changes in CD-I HaM/ICR mice reared under standard laboratory conditions. JNCI 55: 37–43
Kincaid SA, Carlton WW (1982) Experimental copper deficiency in laboratory mice. Lab Anim Sci 32: 491– 494
Liu S-K (1970) Acquired cardiac lesions leading to congestive heart failure in the cat. Am J Vet Res 31: 2071–2088
Lockwood WR, Clower BR, Hetherington F (1969) Light and electron microscopy of diet-induced atrial thrombosis in TS mice. I. Primary changes in the endocardium. Am J Anat 126: 185–200
McMartin DN (1977) Spontaneous atrial thrombosis in aged Syrian hamsters. I. Incidence and pathology. Thromb Haemostas 38: 447–456
McMartin DN, Dodds WJ (1982) Atrial thrombosis in aged Syrian hamsters. Am J Pathol 107: 277–279
Sichuk G, Bettigole RE, Der BK, Fortner JG (1965) Influence of sex hormones on thrombosis of left atrium in Syrian (golden) hamsters. Am J Physiol 208: 465– 470
Silber EN, Katz LN (1975) Thromboembolism. In: Heart disease. MacMillan, New York, pp 537–539
Wilens SL, Sproul EE (1938) Spontaneous cardiovascular disease in the rat. I. Lesions of the heart. Am J Pathol 14: 177–199
Wilson JL, Ashburn AD, Williams WL (1970) Effects of sex hormones on diet-induced atrial thrombosis. Anat Rec 168: 331–338
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Carlton, W.W., Engelhardt, J.A. (1991). Atrial Thrombosis, Rat, Mouse, and Hamster. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Cardiovascular and Musculoskeletal Systems. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76533-9_7
Download citation
DOI: https://doi.org/10.1007/978-3-642-76533-9_7
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-76535-3
Online ISBN: 978-3-642-76533-9
eBook Packages: Springer Book Archive