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Cardiotoxicity of Ionophores, Rat

  • Chapter
Cardiovascular and Musculoskeletal Systems

Part of the book series: Monographs on Pathology of Laboratory Animals ((LABORATORY))

Abstract

The ionophores, which will be described further in this paper, are polyether antibiotics. Rats that die from acute ionophore toxicity usually do not have remarkable gross cardiac lesions. Comparative LD50 values in rats given ionophores are presented in Table 2. Nonspecific changes such as vascular congestion and petechial hemorrhages on epicardial fat occur in animals that die soon after dosing. The rats that die following multiple exposure to ionophores administered via the feed have pale streaks or diffuse pallor of the ventricular myocardium. In subchronic studies, cardiomegaly with dilatation of right ventricle and gross evidence of congestive heart failure such as increased pericardial fluid, hydrothorax, pulmonary edema, ascites, and an enlarged, mottled liver occurs in some rats (Figs. 22,23).

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Authors
  1. Meliton N. Novilla
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  2. Glen C. Todd
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Editor information

Editors and Affiliations

  1. Emeritus, Harvard Medical School, ILSI Research Foundation, 1126 Sixteenth Street, N.W., 20036, Washington D.C., USA

    Thomas Carlyle Jones D.V.M., D.Sc. (Professor of Comparative Pathology) (Professor of Comparative Pathology)

  2. Medizinische Hochschule Honnover, Institut für Experimentelle Pathologie, Konstanty-Gutschow-Strasse 8, W-3000, Hannover 61, Federal Republic of Germany

    Ulrich Mohr M.D. (Professor of Experimental Pathology) (Professor of Experimental Pathology)

  3. New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Drive, 01772, Southborough, MA, USA

    Ronald Duncan Hunt D.V.M. (Professor of Comparative Pathology) (Professor of Comparative Pathology)

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© 1991 Springer-Verlag Berlin Heidelberg

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Novilla, M.N., Todd, G.C. (1991). Cardiotoxicity of Ionophores, Rat. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Cardiovascular and Musculoskeletal Systems. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76533-9_5

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  • DOI: https://doi.org/10.1007/978-3-642-76533-9_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76535-3

  • Online ISBN: 978-3-642-76533-9

  • eBook Packages: Springer Book Archive

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