Dystonia Musculorum Deformans, Sprague-Dawley Rat with the Dystonic (dt) Mutation

  • Henry J. Baker
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)

Abstract

The dystonias are a heterogeneous group of motor disorders characterized by sustained, involuntary twisting movements (Fahn and Eldridge 1976). Although dystonia can be a Symptom of a variety of neuromuscular diseases, it is the primary clinicopathologic hallmark of the family of human inherited torsion dystonias known as dystonia musculorum deformans. The pathogenetic basis of these diseases is unknown and no characteristic light or electron microscopic lesions have been observed (Zeman 1976). In 1980, Baker et al. and Lorden et al. (1984) described Sprague-Dawley rats with clinical and biochemical characteristics similar to human inherited torsion dystonias, and named the mutation Dystonie (dt).

Keywords

Dopamine Morphine Neuropathy Norepinephrine Haloperidol 

References

  1. Griffiths RC (1968) Osteochondritis dissecans of the canine shoulder. J Am Vet Med Assoc 153: 1733–1735PubMedGoogle Scholar
  2. Grondalen T (1974) Osteochondrosis and arthrosis in pigs. VI. Relationship to feed level and calcium, phosphorus and protein levels in the ration. Acta Vet Scand 15: 147–169PubMedGoogle Scholar
  3. Grondalen T, Grondalen J (1974) Osteochondrosis and arthrosis in pigs. IV. Effect of overloading on the distal epiphyseal plate of the ulna. Acta Vet Scand 15: 63–60Google Scholar
  4. Hill MA, Ruth GR, Hilley HD, Hansgen DC (1984) Dyschondroplasias, including osteochondrosis, in boars between 25 and 169 days of age: histologic changes. Am J Vet Res 45: 903–916PubMedGoogle Scholar
  5. Hill MA, Ruth GR, Hilley HD, Torrison JL, Bagent JK, Leman AD (1985) Dyschondroplasia of growth cartilages (osteochondrosis) in crossbred commercial pigs at one and 15 days of age: radiological, angiomicro- graphic and histological findings. Vet Rec 116: 40–47PubMedCrossRefGoogle Scholar
  6. Hoppe F, Philipsson J (1985) A genetic study of osteochondrosis dissecans in Swedish horses. Equine Pract 7: 7–8Google Scholar
  7. Kato M, Onodera T (1984) Spontaneous osteochon-drosis in rats. Lab Anim 18: 179–187PubMedCrossRefGoogle Scholar
  8. Kato M, Onodera T (1986) Observation on the development of osteochondrosis in young rats. Lab Anim 20: 249–256PubMedCrossRefGoogle Scholar
  9. Kato M, Onodera T (1987) Early changes of osteo-chondrosis in medial femoral condyles from rats. Vet Pathol 24: 80–86PubMedGoogle Scholar
  10. Kincaid SA, Lidvall ER (1983) Observations on the postnatal morphogenesis of the porcine humeral condyle and the pathogenesis of osteochondrosis. Am J Vet Res 44: 2095–2103PubMedGoogle Scholar
  11. Kincaid SA, van Sickle DC (1981) Regional histochemical and thickness variations of adult canine articular cartilage. Am J Vet Res 42: 428–432PubMedGoogle Scholar
  12. Kincaid SA, Rudd RG, Evander SA (1985) Lipids of normal and osteochondritic cartilage of the immature canine humeral head. Am J Vet Res 46: 1060–1065PubMedGoogle Scholar
  13. Knecht CD, van Sickle DC, Blevins WE, Avolt MD, Hughes RB, Cantwell HD (1977) Osteochondrosis of the shoulder and stifle in 3 of 5 Border Collie littermates. J Am Vet Med Assoc 170: 58–60PubMedGoogle Scholar
  14. McCaskey PC, Rowland GN, Page RK, Minear LR (1982) Focal failures of endochondral ossification in the broiler. Avian Dis 26: 701–717PubMedCrossRefGoogle Scholar
  15. Olsson S-E, Reiland S (1978) The nature of osteochondrosis in animals. Summary and conclusions with comparative aspects on osteochondritis dissecans in man. Acta Radiol [Suppl] (Stockh) 358: 299–306Google Scholar
  16. Paatsama S, Rokkanen P, Jussila J (1975) Etiological factors in osteochondritis dissecans. An experimental study into the etiological factors in osteochondritis dissecans in the canine humeral head using overloading with and without somatotropin and thyrotropin hormone treatment and mechanical trauma. Acta Orthop Scand 46: 906–918PubMedCrossRefGoogle Scholar
  17. Poulos PW Jr (1978) Tibia dyschondroplasia (osteochondrosis) in the turkey. A morphologic investigation. Acta Radiol [Suppl] (Stockh) 358: 197–227Google Scholar
  18. Reiland S (1978) Morphology of osteochondrosis and sequelae in pigs. Acta Radiol [Suppl] (Stockh) 358: 45–90Google Scholar
  19. Reiland S, Strömberg B, Olsson S-E, Dreimanis I, Olsson IG (1978) Osteochondrosis in growing bulls. Pathology, frequency and severity of different feedings. Acta Radiol [Suppl] (Stockh) 358: 179–196Google Scholar
  20. Rejno S, Strömberg B (1978) Osteochrondrosis in the horse. II. Pathology. Acta Radiol [Suppl] (Stockh) 358: 153–178Google Scholar
  21. Robins GM (1978) Osteochondritis dissecans in the dog. Aust Vet J 54: 272–279PubMedCrossRefGoogle Scholar
  22. Simon WH (1971) Scale effects in animal joint. II. Thickness and elasticity in the deformability of articular cartilage. Arthritis Rheum 14: 493–502PubMedCrossRefGoogle Scholar
  23. Strömberg B (1976) Osteochondrosis dissecans of the stifle joint in the horse: a clinical, radiographic and pathologic study. J Am Vet Radiol Soc 17: 117–124CrossRefGoogle Scholar
  24. Vaughan LC, Jones DG (1968) Osteochondritis dissecans of the head of the humerus in dogs. J Small Anim Pract 9: 283–294PubMedCrossRefGoogle Scholar
  25. Woodard JC ( 1978 a) Rickets and osteomalacia. In: Be- nirschke K, Garner FM, Jones TC (eds) Pathology of laboratory animals, vol 1. Springer, Berlin Heidelberg New York, pp 727–729Google Scholar
  26. Woodard JC ( 1978 b) Degenerative joint disease. In: Benirschke K, Garner FM, Jones TC (eds) Pathology of laboratory animals, vol 1. Springer, Berlin Heidelberg New York, pp 790–792Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • Henry J. Baker

There are no affiliations available

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