Skip to main content
SpringerLink
Log in

Endomyocardial Neurofibromatosis, Rat

  • Chapter
Cardiovascular and Musculoskeletal Systems

Part of the book series: Monographs on Pathology of Laboratory Animals ((LABORATORY))

  • 188 Accesses

Abstract

With the naked eye no abnormalities are visible in mild cases of the disease. In severe cases, the lesions appear as whitish thickening of the endocardium (Fig. 61) and may even form large tumor masses which bulge into the left ventricle (Boorman et al. 1973). Sometimes endomyocardial neurofibromatosis is combined with hypertrophy of the myocardium.

Editor’s note. The lesions described in this paper are similar to those described by Novilla and Sandusky, starting on p. 56. Interpretations in these two reports differ significantly and reflect the undecided stage of understanding of this subject. It appears appropriate that our readers consider the viewpoints of all these authors.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Altman NH, Goodman DG (1979) Neoplastic diseases. In: Baker HJ, Lindsay JR, Weisbroth SH (eds) The laboratory rat, vol 1. Academic, New York, pp 333–376

    Google Scholar 

  • Berman JJ, Rice JM, Reddick R (1980) Endocardial schwannomas in rats. Arch Pathol Lab Med 104:187– 191

    PubMed  CAS  Google Scholar 

  • Boorman GA, Zurcher C, Hollander CF, Feron VJ (1973) Naturally occurring endocardial disease in the rat. Arch Pathol 96: 39–45

    PubMed  CAS  Google Scholar 

  • Burek JD (1978) Pathology of aging rats. CRC, Boca Raton Davies JNP, Ball JD (1955) The pathology of endo-myocardial fibrosis in Uganda. Br Heart J17: 337–359

    Google Scholar 

  • Frith CH, Farris HE, Highman B (1977) Endocardial fibromatous proliferation in a rat. Lab Animal Sci 27: 114–117

    CAS  Google Scholar 

  • Harbin AD, Gerson MC, O’Connell JB (1984) Simulation of acute myopericarditis by constrictive pericar-dial disease with endomyocardial fibrosis due to methysergide therapy. J Am Coll Cardiol 4: 196–199

    Article  PubMed  CAS  Google Scholar 

  • Hoch-Ligeti C, Harris PN, Stewart HL (1983) Endocardial tumors induced by carbamate or fluorenylacetanide derivatives in rats. JNCI 71: 211–216

    PubMed  CAS  Google Scholar 

  • Hoch-Ligeti C, Restrepo C, Stewart HL (1986) Comparative pathology of cardiac neoplasms in humans and in laboratory rodents: a reviw. JNCI 76: 127–142

    PubMed  CAS  Google Scholar 

  • Holzhausen JH, Schreiber D (1977) Elektronenmikroskopische Untersuchungen an Friihstadien experimenteller Herztumoren bei Ratten. Exp Pathol 13: 20–31

    CAS  Google Scholar 

  • Ivankovic S (1976) Tumours of the heart. IARC Sci Publ 6: 313–319

    PubMed  Google Scholar 

  • Ketkar M, Reznik G, Haas H, Hilfrich J, Mohr U (1977) Tumors of the heart and stomach induced in European hamsters by intravenous administration of N- methyl-Af-nitrosourea. JNCI 58: 1695–1699

    PubMed  CAS  Google Scholar 

  • Landes C, Ruefenacht HJ, Naylor DC, Krinke GJ (1988) Rat endomyocardial disease: a neural origin? Exp Pathol 34: 65–69

    PubMed  CAS  Google Scholar 

  • Lewis DJ (1980) Sub-endocardial fibrosis in the rat: a light and electron microscopic study. J Comp Pathol 90: 577–583

    Article  PubMed  CAS  Google Scholar 

  • Maekawa A, Odashima S (1975) Spontaneous tumors in ACI/N rats. JNCI 55: 1437–1445

    PubMed  CAS  Google Scholar 

  • Mayer D, Bannasch P (1983) Endomyocardial fibrosis in rats treated with TV-nitrosomorpholine. Virchows Arch [A] 401: 129–135

    Article  CAS  Google Scholar 

  • Naylor DC, Krinke GJ, Zak F (1986) A comparison of endomyocardial disease in the rat with endomyocardial fibrosis in man. J Comp Pathol 96: 473–483

    Article  PubMed  CAS  Google Scholar 

  • Prejean JD, Peckham JC, Casey AE, Griswold DP, Weisburger EK, Weisburger JH (1973) Spontaneous tumors in Sprague Dawley rats and Swiss mice. Cancer Res 33: 2768–2773

    PubMed  CAS  Google Scholar 

  • Rabson AS, Branigan WJ, Legallais FY (1960) Production of tumours in Rattus ( Mastomys) natalensis by polyoma virus. Nature 187: 423–425

    Article  PubMed  CAS  Google Scholar 

  • Selye H (1958) Experimental production of endomyocardial fibrosis. Lancet 1: 1352–1353

    Google Scholar 

  • Toth B (1970) Susceptibility of guinea pigs to chemical carcinogens: 7,12-dimethylbenz[a]anthracene and urethan. Cancer Res 30: 2583–2589

    PubMed  CAS  Google Scholar 

  • Turusov VS, Cabral R (1988) Histogenesis of endocardial tumours of rats. Eksp Onkol 10: 23–26

    CAS  Google Scholar 

  • Vesselinovitch SD, Mihailovich N (1968) The development of neurogenic neoplasms, embryonal kidney tumors, Harderian gland adenomas, Anitschkow cell sarcomas of the heart, and other neoplasins in urethan-treated newborn rats. Cancer Res 28: 888–897

    PubMed  CAS  Google Scholar 

  • Vesselinovitch SC, Rao KVN, Mihailovich N, Rice JM, Lombard LS (1974) Development of broad spectrum of tumors by ethylnitrosourea in mice and the modifying role of age, sex, and strain. Cancer Res 34: 2530–2538

    PubMed  CAS  Google Scholar 

  • Vinores SA, Bonnin JM, Rubinstein LJ, Marangos PJ (1984) Immunohistochemical demonstration of neuron-specific enolase in neoplasms of the CNS and other tissues. Arch Pathol Lab Med 108: 536–540

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. Peter Bannasch
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Doris Mayer
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Emeritus, Harvard Medical School, ILSI Research Foundation, 1126 Sixteenth Street, N.W., 20036, Washington D.C., USA

    Thomas Carlyle Jones D.V.M., D.Sc. (Professor of Comparative Pathology) (Professor of Comparative Pathology)

  2. Medizinische Hochschule Honnover, Institut für Experimentelle Pathologie, Konstanty-Gutschow-Strasse 8, W-3000, Hannover 61, Federal Republic of Germany

    Ulrich Mohr M.D. (Professor of Experimental Pathology) (Professor of Experimental Pathology)

  3. New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Drive, 01772, Southborough, MA, USA

    Ronald Duncan Hunt D.V.M. (Professor of Comparative Pathology) (Professor of Comparative Pathology)

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Bannasch, P., Mayer, D. (1991). Endomyocardial Neurofibromatosis, Rat. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Cardiovascular and Musculoskeletal Systems. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76533-9_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-76533-9_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76535-3

  • Online ISBN: 978-3-642-76533-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation