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Permeability Changes during Experimental Endotoxemia and Sepsis

  • Conference paper
Book cover Shock, Sepsis, and Organ Failure

Abstract

Pulmonary transmicrovascular fluid flux has traditionally been evaluated in relationship to the Starling-Landis equation [Starling 1890]:

$$Qf = kf(Pmv - Pi) - \sigma (\pi pl - \pi i)$$

In this equation Qf is the net fluid flux, kf is the filtration coefficient, Pmv the capillary pressure, Pi the pressure in the interstitial space, a the reflection coefficient, πpl the oncotic pressure in the plasma and πi the oncotic pressure of the interstitial fluid. Since lymph flow is a very accurate index of the net fluid flux (Qf) the flow of lymph (QL) has been used almost exclusively to define this term. The caudal mediastinal lymph node of the sheep has a single efferent and surgical manipulation of the systemic contamination to the node resulting in lymph which is almost exclusively from the lung [Staub 1975]. The ease with which the lung lymphatic can be cannulated and the facility with which you can then obtain the remainder of the terms in the Starling-Landis equation have resulted in the use of ovine models to study several aspects of microvascular pathophysiology.

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Author information

Authors and Affiliations

  1. Departments of Anesthesiology, Physiology, and Surgery, The University of Texas Medical Branch and Shriners Burns Institute, Galveston, Texas, USA

    Daniel L. Traber, David N. Herndon, Kentero Fujioka & Lillian D. Traber

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  1. Daniel L. Traber
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  2. David N. Herndon
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  3. Kentero Fujioka
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  4. Lillian D. Traber
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Editor information

Editors and Affiliations

  1. Ludwig-Boltzmann-Institut für experimentelle und klinische Traumatologie, Donaueschingenstraße 13, 1200, Wien, Austria

    Günther Schlag  & Heinz Redl  & 

  2. Maryland Institute for Emergency Medical Services Systems, Department of Surgery, Medical School, University of Maryland, 22 S. Greene Street, Baltimore, MD, 21201, USA

    John H. Siegel MD

  3. School of Medicine, John Hopkins University, 22 S. Greene Street, Baltimore, MD, 21201, USA

    John H. Siegel MD

  4. Shriners Burns Institute and The University of Texas Medical Branch, 610 Texas Avenue, Galveston, Texas, 77550, USA

    Daniel L. Traber

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© 1991 Springer-Verlag Berlin, Heidelberg

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Traber, D.L., Herndon, D.N., Fujioka, K., Traber, L.D. (1991). Permeability Changes during Experimental Endotoxemia and Sepsis. In: Schlag, G., Redl, H., Siegel, J.H., Traber, D.L. (eds) Shock, Sepsis, and Organ Failure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76511-7_17

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  • DOI: https://doi.org/10.1007/978-3-642-76511-7_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53831-8

  • Online ISBN: 978-3-642-76511-7

  • eBook Packages: Springer Book Archive

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