Pathogenetic Linkages between Gram Negative Septic Shock and the Cellular Initiation and Regulation of Coagulation

  • Thomas S. Edgington
Conference paper


Gram negative sepsis elicits complex pathophysiologic responses which are often severe and include disseminated intravascular coagulation and disseminated intravascular microthrombosis (DIC) within the context of hypotension, leukopenia, and a set of profound tissue injury associated with general cytokine generation and frequent local accumulation and activation of leukocytes and all to common terminal occurrence of multiple organ failure and death. DIC is common, not always fully established in the clinical setting or fully analyzed, and can frequently progress to a shock state and frequent death (McKay, 1964; Hinshaw and Cox, 1972).


Septic Shock Tissue Factor Disseminate Intravascular Coagulation Disseminate Intravascular Coagulation Tissue Factor Activity 
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Copyright information

© Springer-Verlag Berlin, Heidelberg 1991

Authors and Affiliations

  • Thomas S. Edgington
    • 1
  1. 1.Vascular Cell and Molecular Biology Program, Department of ImmunologyResearch Institute of Scripps ClinicLa JollaUSA

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