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Modulation of Hepatic Function in Endotoxemia by Intercellular Communication

  • Conference paper
Shock, Sepsis, and Organ Failure

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Abstract

One of the hallmarks of endotoxemia is the impairment of glucose homeostasis (Hinshaw, 1976). The liver is a major site of glycogen storage and plays a pivotal role in the homeostasis of blood glucose. Glycogen synthesis and breakdown, and gluconeogenesis are under strict hormonal regulation. Besides the well known stimulators of glycogenolysis, i.e. glucagon, epinephrine, vasopressin (VP) (Kraus-Friedman 1984; Exton 1985), other factors e.g. the tumor-promoter phorbol ester, phorbol 12-myristate 13-acetate (PMA) (Garcia-Sainz and Hernandez-Sotomayor 1985) and platelet-activating factor (PAF) (Shukia et al 1983) also stimulate hepatic glycogenolysis. Endotoxemia is also associated with alterations in hepatic fatty acid and oxidation and ketogenesis (Wannemacher et al 1981).

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Authors and Affiliations

  1. Department of Physiology, Louisiana State Medical Center, New Orleans, LA, 70112, USA

    J. A. Spitzer

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  1. J. A. Spitzer
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Editors and Affiliations

  1. Ludwig-Boltzmann-Institut für experimentelle und klinische Traumatologie, Donaueschingenstraße 13, 1200, Wien, Austria

    Günther Schlag  & Heinz Redl  & 

  2. Maryland Institute for Emergency Medical Services Systems, Department of Surgery, Medical School, University of Maryland, 22 S. Greene Street, Baltimore, MD, 21201, USA

    John H. Siegel MD

  3. School of Medicine, John Hopkins University, 22 S. Greene Street, Baltimore, MD, 21201, USA

    John H. Siegel MD

  4. Shriners Burns Institute and The University of Texas Medical Branch, 610 Texas Avenue, Galveston, Texas, 77550, USA

    Daniel L. Traber

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© 1991 Springer-Verlag Berlin, Heidelberg

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Spitzer, J.A. (1991). Modulation of Hepatic Function in Endotoxemia by Intercellular Communication. In: Schlag, G., Redl, H., Siegel, J.H., Traber, D.L. (eds) Shock, Sepsis, and Organ Failure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76511-7_10

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  • DOI: https://doi.org/10.1007/978-3-642-76511-7_10

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  • Online ISBN: 978-3-642-76511-7

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