Thymic and Extrathymic Development of Human γ/δT Cells
By immunohistochemical criteria. γ/δ cells represent only a minor population of cells in the developing human thymus (0.02%–0.5%) which remains relatively the same in post-natal thymus (0.02%-0.1%) (Campana et al. 1989). However, it is not clear whether different populations of γ/δ T cells reside in the thymus at different times during fetal gestation. Molecular analysis of human γ/δ leukemic lines suggests that there is a sequential and ordered activation of the human T cell receptor gamma locus during thymic ontogeny (Kimura et al, 1987; VanDongen et al, 1987; Triebel et al, 1988;). In order to achieve a better understanding of the origin and development of human γ/δ T cells, the developmental regulation and expression of all of the known Vγ and Vδ genes during fetal ontogeny needs to be studied.
KeywordsLeukemia Recombination Prep eDNA
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