Thymic and Extrathymic Development of Human γ/δT Cells
By immunohistochemical criteria. γ/δ cells represent only a minor population of cells in the developing human thymus (0.02%–0.5%) which remains relatively the same in post-natal thymus (0.02%-0.1%) (Campana et al. 1989). However, it is not clear whether different populations of γ/δ T cells reside in the thymus at different times during fetal gestation. Molecular analysis of human γ/δ leukemic lines suggests that there is a sequential and ordered activation of the human T cell receptor gamma locus during thymic ontogeny (Kimura et al, 1987; VanDongen et al, 1987; Triebel et al, 1988;). In order to achieve a better understanding of the origin and development of human γ/δ T cells, the developmental regulation and expression of all of the known Vγ and Vδ genes during fetal ontogeny needs to be studied.
KeywordsFetal Liver Gene Segment Cell Antigen Receptor Human Fetal Tissue Fetal Thymus
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