Abstract
T cells bearing the γδ T cell receptor have been commonly found to display non-MHC-restricted, NK-like cytolytic activity (Moingeon 1987, Bosnes 1989, Fisch 1990). Other subsets of γδ T cells proliferate in response to mycobacterial antigens, in particular the 65 kd heat shock protein (HSP) of mycobacteria (Holoshitz 1989, Modlin 1989, Haregewoin 1989, O’Brien 1989, Janis 1989, Kabelitz 1990). We have previously reported four CD4-CD8- γδ T cell clones isolated from the synovial fluid of a patient with rheumatoid arthritis. These clones were selected by virtue of their proliferative response to mycobacteria and were found to recognize the mycobacterial HSP65. Their reactivity to mycobacteria was not restricted by MHC. In the present report we studied the cytolytic activity of these cells. We found that our γδ T cells display “promiscuous” non-MHC-restricted cytolytic activity against neoplastic cells. The cytolytic activity was not directed against exogenously added HSP65 or endogenous HSPs induced by heat. These results suggest that the cytolytic activity and recognition of soluble antigens are two distinct functional properties.
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© 1991 Springer-Verlag Berlin · Heidelberg
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Holoshitz, J., Bayne, N.K., McKinley, D.R., Jia, Y. (1991). A Dichotomy Between the Cytolytic Activity and Antigen-Induced Proliferative Response of Human γδ T Cells. In: Pfeffer, K., Heeg, K., Wagner, H., Riethmüller, G. (eds) Function and Specificity of γ/δ T Cells. Current Topics in Microbiology and Immunology, vol 173. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76492-9_22
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DOI: https://doi.org/10.1007/978-3-642-76492-9_22
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