Development of Human T Cells Expressing TCR γδ In Vitro
Human T cell differentiation is believed to occur largely in the thymus. (However, the occurrence of some extrathymic differentiation sites(s), particularly for cells expressing TCRγδ, has been suggested. For example, in adults where the thymus has involute, T cell development nevertheless continues; one evidence is the reconstitution of the T cell repertoire after bone marrow transplantation.) The following studies represent our initial effort to investigate the role of the human thymus in T cell differentiation in vitro, especially in the development of TCRγδ cells.
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