Development of Human T Cells Expressing TCR γδ In Vitro

  • V. Groh
  • M. Fabbi
  • J. L. Stromminger
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 173)

Abstract

Human T cell differentiation is believed to occur largely in the thymus. (However, the occurrence of some extrathymic differentiation sites(s), particularly for cells expressing TCRγδ, has been suggested. For example, in adults where the thymus has involute, T cell development nevertheless continues; one evidence is the reconstitution of the T cell repertoire after bone marrow transplantation.) The following studies represent our initial effort to investigate the role of the human thymus in T cell differentiation in vitro, especially in the development of TCRγδ cells.

Keywords

Phorbol 

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1991

Authors and Affiliations

  • V. Groh
    • 1
  • M. Fabbi
    • 1
  • J. L. Stromminger
  1. 1.Department of Biochemistry and Molecular BiologyUniversityCambridgeUSA

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