Cyclic Nucleotide-gated Channels — A Family of Proteins Involved in Vertebrate Photoreception and Olfaction

  • U. B. Kaupp
  • M. Vingron
  • W. Altenhofen
  • W. Bönigk
  • E. Eismann
  • J. Ludwig
Part of the Research Reports in Physics book series (RESREPORTS)


Cation channels that are directly gated by guanosine 3′,5′-cyclic monophosphate (cGMP) control the flow of ions across the surface membrane of vertebrate rod and cone photoreceptor cells. A similar channel, gated by adenosine 3′,5′-cyclic monophosphate (cAMP) exists in vertebrate olfactory sensory neurons. The channel polypeptide of rod photoreceptors has been identified and the amino acid sequence of the channel polypeptide in rod and olfactory cells has been determined by cloning of cDNA. Although the cyclic nucleotide-gated channels functionally belong to the class of ligand-gated channels, they share some structural features with voltage-gated channels.


Disk Membrane Outward Rectification Identical Amino Acid Residue Membrane Electric Field Hydropathicity Profile 
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  1. Altenhofen, W., Ludwig, J., Eismann, E., Kraus, W., Bönigk, W. and Kaupp, U.B. (1991) Proc. Natl. Acad. Sci. USA - in pressGoogle Scholar
  2. Barker, W.C., Hunt, L.T., George, D.G., Yeh, L.S., Chen, H.R., Blomquist, M.C., Seibel-Ross, E., Elzanowski, A., Hong, M.K., Ferrick, D.A., Bair, J.K., Chen, S.L. and Ledley, R.S. (1986) National Biomedical Research Foundation Google Scholar
  3. Bauer, P.J. (1988) J. Physiol. (London) 401, 309–327Google Scholar
  4. Baumann, A., Grupe, A., Ackermann, A. and Pongs, O. (1988) EMBO J. 7, 2457–2463PubMedGoogle Scholar
  5. Bodoia, R.D. and Detwiler, P.B. (1985) J. Physiol. (London) 367, 183–216Google Scholar
  6. Breer, H., Boekhoff, I. and Toreilus, E. (1990) Nature 345, 65–68PubMedCrossRefGoogle Scholar
  7. Cannon, J.F. and Tachell, K. (1987) Mol Cell Biol 7, 2653–2663PubMedGoogle Scholar
  8. Caretta, A. and Cavaggioni, A. (1983) Eur. J. Biochem. 132, 1–8PubMedCrossRefGoogle Scholar
  9. Caretta, A. and Saibil, H. (1989) J. Cell Biol. 108, 1517–1522PubMedCrossRefGoogle Scholar
  10. Caretta, A., Cavaggioni, A. and Sorbi, R.T. (1985) Eur. J. Biochem. 153, 49–53PubMedCrossRefGoogle Scholar
  11. Cervetto, L., Menini, A., Rispoli, G. and Torre, V. (1988) J. Physiol (London) 406, 181–198Google Scholar
  12. Charbonneau, H., Prusti, R.K., LeTrong, H., Sonnenburg, W.K., Mullaney, P.J., Walsh, K.A. and Beavo, J.A. (1990) Proc. Natl Acad. Sci. USA 87, 288–292PubMedCrossRefGoogle Scholar
  13. Clack, J.W. and Stein, P.J. (1988) Proc. Natl Acad. Sci. USA 85, 9806–9810PubMedCrossRefGoogle Scholar
  14. Cook, N.J., Hanke, W. and Kaupp, U.B. (1987) Proc. Natl Acad. Sci. USA 84, 585–589PubMedCrossRefGoogle Scholar
  15. Cook, N.J., Molday, L.L., Reid, D, Kaupp, U.B. and Molday, R.S. (1989) J. Biol Chem. 264, 6996–6999PubMedGoogle Scholar
  16. Cook, N.J., Zeilinger, C., Koch, K.-W. and Kaupp, U.B. (1986) J. Biol Chem. 261, 17033–17039PubMedGoogle Scholar
  17. Delgado, R., Hidalgo, P., Diaz, F., Latorre, R. and Labarca, P. (1991) Proc. Natl Acad. Sci. USA 85, 2424–2428Google Scholar
  18. Dhallan, R.S, Yau, K.-W, Schrader, K.A. and Reed, R.R. (1990) Nature 347, 184–187PubMedCrossRefGoogle Scholar
  19. DiFrancesco, D. and Tortora, P. (1991) Nature 351, 145–147PubMedCrossRefGoogle Scholar
  20. Fain, G.L. and Matthews, H.R. (1990) Trends Neurosci. 13, 378–384PubMedCrossRefGoogle Scholar
  21. Fesenko, E.E, Kolesnikov, S.S. and Lyubarsky, A.L. (1985) Nature 313, 310–313PubMedCrossRefGoogle Scholar
  22. Foster, J.L, Higgins, G.C. and Jackson, F.R. (1988) J. Biol Chem. 263, 1676–1681PubMedGoogle Scholar
  23. Hanke, W, Cook, N.J. and Kaupp, U.B. (1988) Proc. Natl Acad. Sci. USA 85, 94–98PubMedCrossRefGoogle Scholar
  24. Haynes, L.W. and Yau, K.-W. (1990) J. Physiol (London) 429, 451–481Google Scholar
  25. Haynes, L.W., Kay, A.R. and Yau, K.-W. (1986) Nature 321, 66–70PubMedCrossRefGoogle Scholar
  26. Hodgkin, A.L., McNaughton, P.A. and Nunn, B.J. (1985) J. Physiol (London) 358, 447–468Google Scholar
  27. Hsu, S.-C. and Molday, R.S. (1990) J. Biol Chem. 265, 13308–13313PubMedGoogle Scholar
  28. Jan, L.Y. and Jan, Y.N. (1990) Nature 345, 672PubMedCrossRefGoogle Scholar
  29. Karpen, J.W, Loney, D.A. and Baylor, D.A. (1990) Biophys. J. 57, 372aGoogle Scholar
  30. Karpen, J.W., Zimmerman, A.L., Stryer, L. and Baylor, D.A. (1988) Proc. Natl Acad. Sci. USA 85, 1287–1291PubMedCrossRefGoogle Scholar
  31. Kaupp, U.B., Hanke, W., Simmoteit, R. and Lühring, H. (1988) Cold Spring Harbor Symposia on Quantitative Biology, Vol. 53, pp. 407–415PubMedCrossRefGoogle Scholar
  32. Kaupp, U.B., Niidome, T., Tanabe, T., Terada, S., Bönigk, W., Stühmer, W., Cook, N.J., Kangawa, K., Matsuo, H., Hirose, T., Miyata, T. and Numa, S. (1989) Nature, 342, 762–766PubMedCrossRefGoogle Scholar
  33. Klein, P.S., Sun, T.J., Saxe III, C.L., Kimmel, A.R., Johnson, R.L. and Devreotes, P.N. (1988) Science 241, 1467–1472PubMedCrossRefGoogle Scholar
  34. Koch, K.-W. and Kaupp, U.B. (1985) J. Biol Chem. 260, 6788–6800PubMedGoogle Scholar
  35. Koch, K.-W. and Stryer, L. (1988) Nature 334, 64–66PubMedCrossRefGoogle Scholar
  36. Kurahashi, T. (1989) J. Physiol. 419, 177–192PubMedGoogle Scholar
  37. Kyte, J. and Doolittle, R.F. (1982) J. Molec. Biol 157, 105–132PubMedCrossRefGoogle Scholar
  38. Lancet, D. and Pace, U. (1987) Trends Biochem. Sci. 12, 63–66CrossRefGoogle Scholar
  39. Light, D.B., Corbin, J.D. and Stanton, B.A. 1990. Nature 344: 336–339PubMedCrossRefGoogle Scholar
  40. Ludwig, J., Margalit, T., Eismann, E., Lancet, D. and Kaupp, U.B. (1990) FEBS Lett. 270, 24–29PubMedCrossRefGoogle Scholar
  41. Lühring, H., Hanke, W., Simmoteit, R. and Kaupp, U.B. (1990) In: Sensory Transduction, eds. Borsellino, A., Cervetto, L. and Torre, V., Plenum Press, New York, 169–173Google Scholar
  42. Matesic, D. and Liebman, P.A. (1987) Nature 326, 600–603PubMedCrossRefGoogle Scholar
  43. Matthews, G. (1986) J. Neurosci. 6, 2521–2526PubMedGoogle Scholar
  44. Matthews, G. and Watanabe, S.-I. (1987) J. Physiol (London) 389, 691–715Google Scholar
  45. Menini, A. (1990) J. Physiol (London) 424, 167–185Google Scholar
  46. Molday. L.L., Cook, N.J., Kaupp, U.B. and Molday, R.S. (1990) J. Biol Chem. 265, 18690–18695Google Scholar
  47. Molday, R.S., Molday, L.L., Dose, A., Clark-Lewis, I., Illing, M., Eismann, E. and Kaupp, U.B. 1991. J. Biol Chem. submittedGoogle Scholar
  48. Mutzel, R., Lacombe, M.-L., Simon, M.-N., de Gunzburg, J. and Veron, M. (1987) Proc. Natl Acad. Sci. USA 84, 6–10PubMedCrossRefGoogle Scholar
  49. Nakamura, T. and Gold, G.H. (1987) Nature 325, 442–444PubMedCrossRefGoogle Scholar
  50. Noda, M., Takahashi, H., Tanabe, T., Toyosato, M., Furutani, Y., Hirose, T., Asai, M., Inayama, S., Miyata, T. and Numa, S. (1982) Nature 299, 793–797PubMedCrossRefGoogle Scholar
  51. Numa, S. (1989) Harvey Lect. 83, 121–165Google Scholar
  52. Rechid, R., Vingron, M. and Argos, P. (1989) CABIOS 5, 107–113PubMedGoogle Scholar
  53. Sandberg, M., Levy, F.O., Oyen, O., Hansson, V. and Jahnsen, T. (1988) Biochem. Biophys. Res. Commun. 154, 705–711PubMedCrossRefGoogle Scholar
  54. Scott, J.D., Glaccum, M.B., Zoller, M.J., Uhler, M.D., Helfman, D.M., McKnight, G.S. and Krebs, E.G. (1987) Proc. Natl Acad. Sci. USA 84, 5192–5196PubMedCrossRefGoogle Scholar
  55. Shinozawa, T., Sokabe, M., Terada, S., Matsusaka, H. and Yoshizawa, T. (1987) J. Biochem. 102, 281–290PubMedGoogle Scholar
  56. Sibbald, P.R. and Argos, P. (1990) CABIOS - in press -Google Scholar
  57. Stern, J.H., Kaupp, U.B. and MacLeish, P.R. (1986) Proc. Natl Acad. Sci. USA 83, 1163–1167PubMedCrossRefGoogle Scholar
  58. Takio, K, Smith, S.B., Krebs, E.G., Walsh, K.A. and Titani, K. (1984b) Biochemistry 23, 4200–4206PubMedCrossRefGoogle Scholar
  59. Takio, K., Wade, R.D., Smith, S.B., Krebs, E.G., Walsh, K.A. and Titani, K. (1984a) Biochemistry 23, 4207–4218PubMedCrossRefGoogle Scholar
  60. Tanaka, J.C, Eccleston, J.F. and Furman, R.E. (1989) Biochemistry 28, 2776–2784PubMedCrossRefGoogle Scholar
  61. Titani, K., Sasagawa, T., Ericsson, L.H., Kumar, S., Smith, S.B., Krebs, E.G. and Walsh, K.A. (1984) Biochemistry 23, 4193–4199PubMedCrossRefGoogle Scholar
  62. Vingron, M. and Argos, P. (1989) CABIOS 5, 115–121PubMedGoogle Scholar
  63. Weber, I.T. Shabb, J.B. and Corbin, J.D. (1989) Biochemistry 28, 6122–6127Google Scholar
  64. Weber, I.T., Steitz, T.A. Bubis, J. and Taylor, S.S. (1987) Biochemistry 26, 343–351Google Scholar
  65. Yau, K.-W. and Baylor, D.A. (1989) Ann. Rev. Neurosci. 12, 289–327PubMedCrossRefGoogle Scholar
  66. Yau, K.-W. and Nakatani, K. (1984) Nature 309, 352–354PubMedCrossRefGoogle Scholar
  67. Zimmerman, A.L. and Baylor, D.A. (1986) Nature 321, 70–72PubMedCrossRefGoogle Scholar
  68. Zimmerman, A.L., Yamanaka, G., Eckstein, F., Baylor, D.A. and Stryer, L. (1985) Proc. Natl Acad. Sci. USA 82, 8813–8817PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • U. B. Kaupp
    • 1
  • M. Vingron
    • 2
  • W. Altenhofen
    • 1
  • W. Bönigk
    • 1
  • E. Eismann
    • 1
  • J. Ludwig
    • 1
  1. 1.Institut für Biologische InformationsverarbeitungForschungszentrum JülichJülichFed. Rep. of Germany
  2. 2.European Molecular Biology LaboratoryHeidelbergFed. Rep. of Germany

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