Gating Kinetics of the cGMP-Activated Conductance of Retinal Cones

  • K.-W Yau
  • L. W. Haynes
Conference paper
Part of the Research Reports in Physics book series (RESREPORTS)


We briefy summarize here a study of the cyclic GMP-activated conductance in retinal cones. With its lack of desensitization and fast gating kinetics, this conductance is very similar to the homologous conductance in rods. The lack of channel desensitization permits a steady dark current to be maintained, while the fast gating kinetics allow the channel to act as a rapid sensor for the decrease in free cGMP concentration in the photoreceptor outer segment during illumination.


Membrane Patch Photoreceptor Outer Segment cGMP Concentration Retinal Cone Cone Outer Segment 
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  1. Haynes, L.W., Kay, A.R., Yau, K.-W. (1986). Nature 321, 66–70.Google Scholar
  2. Haynes, L.W., Yau, K.-W. (1985). Nature 317, 61–4.Google Scholar
  3. Haynes, L.W., Yau, K.-W. (1990). J. Physiol. Lond. 429, 451–481.Google Scholar
  4. Karpen, J.W., Zimmerman, A.L., Stryer, L., Baylor, D. A. (1988). Proc. Natl. Acad. Sci. U.S.A. 85, 1287–1291.Google Scholar
  5. Matthews, G., Watanabe, S.-I. (1987). J. Physiol. Lond. 389, 691–716.Google Scholar
  6. Pugh, E.N. Jr., Cobbs, W.H. (1986). Vision Res. 26, 1613–1643.Google Scholar
  7. Stryer, L. (1987). Ann. Rev. Neurosci. 9, 87–119.Google Scholar
  8. Yau, K.-W., Baylor, D.A. (1989). Ann. Rev. Neurosci. 12, 289–327.Google Scholar
  9. Yellen, G. (1984). J. Gen. Physiol. 84, 157–186.Google Scholar
  10. Zimmerman, A.L., Baylor, D.A. (1986). Nature 321, 70–72.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • K.-W Yau
    • 1
  • L. W. Haynes
    • 1
  1. 1.Howard Hughes Medical Institute and Department of NeuroscienceJohns Hopkins University School of MedicineBaltimoreUSA

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