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Signal Transduction in Photoreceptor Cells pp 175–179Cite as

Gating Kinetics of the cGMP-Activated Conductance of Retinal Cones

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Part of the book series: Research Reports in Physics ((RESREPORTS))

Abstract

We briefy summarize here a study of the cyclic GMP-activated conductance in retinal cones. With its lack of desensitization and fast gating kinetics, this conductance is very similar to the homologous conductance in rods. The lack of channel desensitization permits a steady dark current to be maintained, while the fast gating kinetics allow the channel to act as a rapid sensor for the decrease in free cGMP concentration in the photoreceptor outer segment during illumination.

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References

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Author information

Author notes

  1. L. W. Haynes

    Present address: Department of Medical Physiology, University of Calgary Health Sciences Centre, Calgary, Alberta, T2N 4N1, Canada

Authors and Affiliations

  1. Howard Hughes Medical Institute and Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA

    K.-W Yau & L. W. Haynes

Authors
  1. K.-W Yau
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  2. L. W. Haynes
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Editor information

Editors and Affiliations

  1. Department of Ophthalmology and Department of Biochemistry and Molecular Biology, University of Florida, 32610, Gainesville, Florida, USA

    Paul A. Hargrave

  2. Institut für Biophysik und Strahlenbiologie, Universität Freiburg, Albertstraße 23, W-7800, Freiburg, Fed. Rep. of Germany

    Klaus Peter Hofmann

  3. Institut für Biologische Informationsverarbeitung, KFA Jülich, Postfach 1913, W-5170, Jülich, Fed. Rep. of Germany

    U. Benjamin Kaupp

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© 1992 Springer-Verlag Berlin Heidelberg

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Yau, KW., Haynes, L.W. (1992). Gating Kinetics of the cGMP-Activated Conductance of Retinal Cones. In: Hargrave, P.A., Hofmann, K.P., Kaupp, U.B. (eds) Signal Transduction in Photoreceptor Cells. Research Reports in Physics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76482-0_13

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  • DOI: https://doi.org/10.1007/978-3-642-76482-0_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53765-6

  • Online ISBN: 978-3-642-76482-0

  • eBook Packages: Springer Book Archive

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