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Cellular and Molecular Basis of Synaptic Transmission

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Cell to Cell Signals in Plants and Animals

Part of the book series: NATO ASI Series ((ASIH,volume 51))

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Abstract

This commentary is based on the proceedings of a NATO workshop held in Göttingen from September 9–13, 1987 on the cellular and molecular basis of synaptic transmission. The reader is mainly referred to the literature quoted in the articles. Due to the limited space available complementary literature and literature which appeared since the meeting can only be cited to a very limited extent. While knowledge regarding both presynaptic and postsynaptic signalling mechanisms and their regulative control is evolving rapidly the article aims to highlight recent developments as well as open questions and future perspectives. Consensus mechanisms are emphasized but the structural, functional and also molecular diversity of the various transmission systems is not ignored.

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References

  1. Ceccarelli, B., Valtorta, F., Hurlbut, W.P. (1988) New evidence supporting the vesicle hypothesis for quantal secretion at the neuromuscular junction. *, 51-72.

    Google Scholar 

  2. Couteaux, R., Spacek, J. (1988): Specializations of subsynaptic cytoplasms. Comparison of axospinous synapses and neuromuscular junctions. *, 25-50.

    Google Scholar 

  3. Hirokawa, N. (1983): Membrane specializations and cytoskeletal structures in the synapse and axon revealed by the quick-freeze, deep-etch method. In: Chang, D.C., Tasaki, I., Adelmanm, W.J., Leuchtag, H.R. (1983): Structure and Function of Excitable Cells. Plenum Press. New York, London. pp. 113–141.

    Google Scholar 

  4. Pfenninger, K., Akert, K., Moor, H., Sandri, C. (1972): J. Neurocytol 1: 129–149.

    Article  PubMed  CAS  Google Scholar 

  5. Smith, S.J., Augustine, G.J. (1988): Calcium ions, active zones and synaptic transmitter release. TINS 11: 458–464.

    PubMed  CAS  Google Scholar 

  6. Stjärne, L. (1989): Basic mechanisms and local modulation of nerve impulse-induced secretion of neurotransmitters from individual sympathetic nerve varicosities. Rev. Physiol. Biochem. Pharmacol. 112: 1–137.

    Article  PubMed  Google Scholar 

  7. Nordmann, J.J., Dayanithi, G. (1988): Release of neuropeptides does not only occur at nerve terminals. Biosci. Rep. 8: 471–483.

    Article  PubMed  CAS  Google Scholar 

  8. Janetzko, A., Zimmermann, H., Volknandt, W. (1989): Intraneuronal distribution of a synaptic vesicle membrane protein: antibody binding sites at axonal membrane compartments and trans-Golgi network and accumulation at nodes of Ranvier. Neuroscience 32: 65–77.

    Article  PubMed  CAS  Google Scholar 

  9. Hirokawa, N., Sobue, K., Kanda, K., Harada, A., Yorifuji, H. (1989): The cytoskeletal architecture of the presynaptic terminal and molecular structure of synapsin 1. J. Cell Biol. 108: 111–126.

    Article  PubMed  CAS  Google Scholar 

  10. Zimmermann, H. (1988): Cholinergic synaptic vesicles. Handbook Exptl. Pharmacol. 86: 349–382.

    Article  Google Scholar 

  11. Winkler, H. (1988): Occurence and mechanism of exocytosis in adrenal medulla and sympathetic nerve. Handb, Exptl, Pharmacol, 90/I:43–118.

    Google Scholar 

  12. Winkler, H., Fischer-Colbrie, R., Obendorf, D., Schwarzenbrunner, U. (1988): Adrenergic and cholinergic vesicles: Are there common antigens and common properties? *, 305-314.

    Google Scholar 

  13. Whittaker, V.P. (1988): The cellular basis of synaptic transmission: An overview. *, 1-23.

    Google Scholar 

  14. Klein, R.L., Duncan, R.W., Selva, T.J., Kong, J.-Y, Clayton, WE., Liaw, Y.-L, Rezk, N.F., Thureson-Klein, A. (1988): Sympatho-adrenal costorage, release and synthesis of enkephalins and catecholamines induced by acute CNS ischemia in pig. *, 377-393.

    Google Scholar 

  15. Agoston, D.V. (1988): Cholinergic co-transmitters. Handb. Eptl. Pharmacol. 86: 479–533.

    Article  Google Scholar 

  16. Thureson-Klein, A.K., Klein, R.L., Zhu, P.C., Kong, J.-Y. (1988): Differential release of transmitters and neuropeptides co-stored in central and peripheral neurons. *, 137-151.

    Google Scholar 

  17. Boarder, M.R. (1989): Presynaptic aspects of cotransmission: relationship between vesicles and neurotransmitters. J. Neurochem. 53: 1–11.

    Article  PubMed  CAS  Google Scholar 

  18. Wiedenmann, B., Franke, W.W. (1988): Synaptophysin: A major cell type-specific protein of neuroendocrine cells. *, 351-356.

    Google Scholar 

  19. Volknandt, W., Henkel, A., Zimmermann, H. (1988): Synaptic vesicle proteins. *, 337-350.

    Google Scholar 

  20. Volknandt, W., Zimmermann, H. (1990): Identical properties of transmembrane synaptic vesicle protein Mr 100,000 in Torpedo and Mr 86,000 in bovine brain. Neurochem. Int.: in press.

    Google Scholar 

  21. Südhof, T.C., Baumert, M., Perin, M.S., Jahn, R. (1989): A synaptic vesicle membrane protein is con-served from mammals to Drosophila. Neuron. 2: 1475–1481.

    Article  PubMed  Google Scholar 

  22. Trifaro, J.-M., Fournier, S., Novas, M.L (1989): The p65 protein is a calmodulin-binding protein present in several types of secretory vesicles. Neuroscience 29: 1–8.

    Article  PubMed  CAS  Google Scholar 

  23. Parsons, S.M., Noremberg, K., Rogers, G.A., Gracz, L.M., Kornreich, W.D., Bahr, B.A., Kaufman, R. (1988): Complexity and regulation in the acetylcholine storage system of synaptic vesicles. *, 325-335.

    Google Scholar 

  24. Fonnum, F., Fykse, E.M., Paulsen, R. (1988): Excitatory amino acids; physiology, anatomy and biochemistry. *, 172-183.

    Google Scholar 

  25. Fykse, E.M., Christensen, H., Fonnum, F. (1989): Comparison of the properties of Γ-aminobutyric acid and L-glutamate uptake into synaptic vesicles isolated from rat brain. J. Neurochem. 52: 946–951.

    Article  PubMed  CAS  Google Scholar 

  26. Isambert, M.-F., Gasnier, B., Laduron, P.M., Henry, J.-P. (1989): Photoaffinity labelling of the monoamine transporter of bovine chromaffin granules and other monoamine storage vesicles using 7-azido-8-(125l)iodoketanserin. Biochemistry 28: 2265–2270.

    Article  PubMed  CAS  Google Scholar 

  27. Hell, J.W., Maycox, P.R., Stadler, H., Jahn, R. (1988): Uptake of GABA by rat synaptic vesicles isolated by a new procedure. EMBO J. 7: 3023–3029.

    PubMed  CAS  Google Scholar 

  28. Kish, P.E., Fischer-Bovenkerk, C., Ueda, T. (1989): Active transport of Γ-aminobutyric acid and glycine into synaptic vesicles. Proc. Natl. Acad. Sci. USA 86: 3877–3881.

    Article  PubMed  CAS  Google Scholar 

  29. Cidon, S., Sihra, T.S. (1989): Characterization of a H+-ATPase in rat brain synaptic vesicles. Coupling to L-glutamate transport. J. Biol. Chem. 264: 8281–8288.

    PubMed  CAS  Google Scholar 

  30. Yamagata, S.K., Noremberg, K., Parsons, S.M. (1989): Purification and subunit composition of a cholinergic synaptic vesicle glycoprotein phosphointermediate-forming ATPase. J. Neurochem. 53: 1345–1353.

    Article  PubMed  CAS  Google Scholar 

  31. Südhof, T.C., Czernik, A.J., Kao, H.-T., Takei, K., Johnston, P.A., Horiuchi, A., Kanazir, D., Wagner, M.A., Perin, M.S., De Camilli, P., Greengard, P. (1989): Synapsins: Mosaics of shared and individual domains in a family of synaptic vesicle phosphoproteins. Science 245: 1474–1480.

    Article  PubMed  Google Scholar 

  32. Simon, J.-P, Aunis, D. (1988): Biochemistry of the chromogranin A protein family. Biochem. J. 262: 1–13.

    Google Scholar 

  33. Stadler, H, Borroni, E., Ploghöft, M., Kiene, M.-L. (1988): Structure and function of synaptic vesicles: new aspects. *, 315-324.

    Google Scholar 

  34. Sihra, T.S., Wang, J.K.T., Gorelick, F.S, Greengard, P. (1989): Translocation of synapsin I in response to depolarization of isolated nerve terminals. Proc. Natl. Acad. Sci. USA 86: 8108–8112.

    Article  PubMed  CAS  Google Scholar 

  35. Thomas, L., Härtung, K., Langosch, D., Rehm, H., Bamberg, E., Franke, W.W., Betz, H. (1988): Identification of synaptophysin as a hexameric channel protein of the synaptic vesicle membrane. Science 242:1050–1053.

    Article  PubMed  CAS  Google Scholar 

  36. Betz, H. (1990): Homology and analogy in transmembrane channel design: lessons from synaptic membrane proteins. Biochemistry, in press.

    Google Scholar 

  37. Rahamimoff, R., De Riemer, S.A., Sakmann, B., Stadler, H., Yakir, N. (1988): Ion channels in synaptic vesicles from Torpedo electric organ. Proc. Natl. Acad. Sci. USA 85: 5310–5314.

    Article  PubMed  CAS  Google Scholar 

  38. Grondai, E.J.M., Zimmermann, H. (1988): Extracellular metabolism of ATP at the cholinergic electromotor synapse; characterization and location of ectonucleotidases. *, 395-410.

    Google Scholar 

  39. Bradford, H.F., Dochtery, M., Joh, T.H., Wu, Y.-Y. (1988): The detection, isolation and properties of subpopulations of mammalian brain synaptosomes of defined transmitter type. *, 153-159.

    Google Scholar 

  40. Raiteri, M., Bonanno, G., Pittaluga, A., Versace, P. (1988): Heterologous carriers located on rat CNS nerve endings and their possible role in modulation of transmitter release. *, 199-213.

    Google Scholar 

  41. Bartfai, T., Iverfeldt, K., Brodin, E., Ögren, S.-O. (1986): Functional consequences of coexistence of classical and peptide neurotransmitters. Prog. Brain. Res. 68: 321–330.

    Article  PubMed  CAS  Google Scholar 

  42. Hökfelt, T., Johansson, O., Ljungdahl, A., Lundberg, J.M,. Schultzberg, M. (1980): Nature 284: 515–521.

    Article  PubMed  Google Scholar 

  43. Stjärne, L. (1988): The new paradigm: sympathetic neurotransmission by lateral interaction between single mixed quanta acting in two different biophases. *, 357-375.

    Google Scholar 

  44. Ehrlich, Y.H., Snider, R.M., Kornecki, E., Garfield, M.G., Lenox, R.H. (1988): Modulation of neuronal signal transduction systems by extracellular ATP. J. Neurochem. 50, 295–301.

    Article  PubMed  CAS  Google Scholar 

  45. Brown, S.J., Luzio, J.P., Richardson, P.J. (1988): The application of immunoaffinity techniques to the study of cholinergic neurobiology. *, 411-424.

    Google Scholar 

  46. Heilbronn, E., Häggblad, J. (1988): Transmitter/modulator induced events related to excitation-contraction coupling in skeletal muscle of vertebrates. Action of ATP. *, 425-441.

    Google Scholar 

  47. Dowdall, M.J., Downie, D.L. (1988): Identity and functional role of neuropeptides in Torpedo electric organ. *, 443-452.

    Google Scholar 

  48. Bauer, K. (1985): Degradation and biological inactivation of neuropeptides. In: Hamprecht, B., Neuhoff, V. (eds.): Neurobiochemistry, 36. Colloquium — Mosbach 1985, Springer. Berlin, Heidelberg, New York, Toronto. pp. 43–54.

    Google Scholar 

  49. Kenny, A.J. (1986): Endopeptidase-24.11: An ectoenzyme capable of hydrolyzing regulatory peptides at the surface of many different cell types. In: Kreutzberg, G.W., Reddington, M., Zimmermann, H. (eds.): Cellular Biology of Ectoenzymes. Springer. Berlin, Heidelberg, New York, Tokyo. pp. 257–271.

    Chapter  Google Scholar 

  50. Kenny, A.J., Turner, A.J. (1987): Ectoenzymes: an update. In: Kenny, A.J., Turner, A.J. (eds.): Mammalian Ectoenzymes. Elsevier. Amsterdam, New York, Oxford. pp. 329–351.

    Google Scholar 

  51. Pappas, G.D., Kriho, V., Becker, R.B. (1988): Fine structural correlates of calcium dynamics in the presynaptic terminal. *, 121-135.

    Google Scholar 

  52. Nagy, A.K., Shuster, T.A., Delgado-Escueta, V. (1989): Rat brain synaptosomal ATP:AMP-phosphotransferase activity. J. Neurochem. 53: 1166–1172.

    Article  PubMed  CAS  Google Scholar 

  53. Blaustein, P., Bartschat, D.K,. Benishin, C.G., Brown, W.E., Colby, K.A., Krueger, B.K., Schneider, M.J., Sorensen, R.G. (1988): Potassium channels in rat brain synaptosomes: pharmacology and toxicology. *, 241-261.

    Google Scholar 

  54. Carvalho, A.P., Santos, M.S., Henriques, A.O., Tavares, P., Carvalho, C.M. (1988): Calcium channels and Na+/Ca2+ exchange in synaptosomes. *, 263-284.

    Google Scholar 

  55. Suszkiw, J.B. (1988): Properties of presynaptic voltage-sensitive calcium channels in rat synaptosomes. *, 285-291.

    Google Scholar 

  56. Schauf, C.L. (1987): Ion channel diversity: a revolution in biology? Sci. Prog. Oxford 71: 459–478.

    CAS  Google Scholar 

  57. Hosey, M.M., Lazdunski, M. (1988): Calcium channels: molecular pharmacology, structure and regulation. J. Membr. Biol. 104: 81–105.

    Article  PubMed  CAS  Google Scholar 

  58. Lemos, J.R., Nordmann, J.J., Cooke, I.M., Stuenkel, E.L. (1986): Single channels and ionic currents in peptidergic nerve terminals. Nature 319: 410–412.

    Article  PubMed  CAS  Google Scholar 

  59. Tsien, R.W., Hess, P., McCleskey, E.W., Rosenberg, R.L. (1987): Calcium channels: mechanisms of selectivity, permeation, and block. Ann. Rev. Biophys. Biophys. Chem. 16: 265–290.

    Article  CAS  Google Scholar 

  60. Dunn, S.M.J. (1988): Multiple calcium channels in synaptosomes: voltage dependence of 1,4 dihydropyridine binding and effects of function. Biochemistry 27: 5275–5281.

    Article  PubMed  CAS  Google Scholar 

  61. Lemos, J.R., Nowycky, M.C. (1989): Two types of calcium channls coexist in peptide-releasing vertebrate nerve terminals. Neuron. 2: 1419–1426.

    Article  PubMed  CAS  Google Scholar 

  62. Krnjevic, K., Leblond, J. (1988): Mechanisms of failure of synaptic transmission during anoxia. * 293-304.

    Google Scholar 

  63. Kandel, E.R., Schwartz, J.H. (1982): Molecular biology of learning: Modulation of transmitter release. Science 218: 433–443.

    Article  PubMed  CAS  Google Scholar 

  64. Catterall, W.A. (1988): Structure and function of voltage-sensitive ion channels. Science 242: 50–81.

    Article  PubMed  CAS  Google Scholar 

  65. Maelicke, A. (1988): Structural similarities between ion channel proteins. TIBS 13: 199–202.

    PubMed  CAS  Google Scholar 

  66. Zimmermann, H., Volknandt, W., Henkel, A., Bonzelius, F., Janetzko, A., Kanaseki, T. (1990): The synaptic vesicle membrane: Origin, axonal distribution, protein components, exocytosis and recycling. Cell Biol. Int. Rep.: in press.

    Google Scholar 

  67. Whittaker, V.P. (1988): Model cholinergic systems: an overview. Handb. Exptl. Pharmacol. 86: 3–22.

    Article  Google Scholar 

  68. Kadota, T., Kadota, K., Tatsuoka, H, Mizote, M., Yamaai, T. (1988): Poststimulation increase of synaptic vesicle number in the preganglionic nerve terminals of the cat sympathetic ganglion in vivo. *, 73-82.

    Google Scholar 

  69. Kriebel, M.E., Fox, G.Q., Kötting, D. (1988): Effect of nerve stimulation, K+ saline and hypertonic saline on classes of quanta, quantal content and synaptic vesicle size distribution of Torpedo electric organ. *, 97-120.

    Google Scholar 

  70. Fox, G.Q., Kriebel, M.E., Kötting, D. (1988): Synaptic vesicle classes in Torpedo and skate electric organ and muscle. *, 83-95.

    Google Scholar 

  71. Vizi, S.E. (1984): Physiological role of cytoplasmic and non-synaptic release of transmitter. Neurochem. Int. 6: 435–440.

    Article  PubMed  CAS  Google Scholar 

  72. Licht, R., Michaelson, D.M. (1988): Spontaneous release of acetylcholine from Torpedo electromotor neurons. *, 215-227.

    Google Scholar 

  73. Marshall, I.G., Parsons, S.M. (1987): The vesicular acetylcholine transport system. TINS 10, 174–177.

    CAS  Google Scholar 

  74. Nicholls, D., Sanchez-Prieto, J. (1988): Synaptosomal bioenergetics and the mechanism of amino acid transmitter release. *, 185-198.

    Google Scholar 

  75. Nicholls, D.G. (1989): Release of glutamate, aspartate, and Γ-aminobutyric acid from isolated nerve terminals. J. Neurochem. 52: 331–341.

    Article  PubMed  CAS  Google Scholar 

  76. Israel, M. (1988): The mechanism of acetylcholine release: its essential component, the mediatophore. *, 229-239.

    Google Scholar 

  77. Knight, D.E., Scrutton, M.C. (1986): Gaining access to the cytosol: the technique and some applications of electropermeabilization. Biochem. J. 234: 497–506.

    PubMed  CAS  Google Scholar 

  78. Augustine, G.J., Charlton, M.P., Smith, S. (1987): Calcium action in synaptic transmitter release. Ann. Rev. Neurosci. 10: 633–693.

    Article  PubMed  CAS  Google Scholar 

  79. Dekker, L.V., De Graan, P.N.E., Versteeg, D.H.G., Oestreicher, A.B., Gispen, W.H. (1988): Phosphorylation of B-50 (GAP43): is correlated with neurotransmitter release in rat hippocampal slices. J. Neurochem. 52: 24–30.

    Article  Google Scholar 

  80. Schweizer, F.E., Schäfer, T., Tapparelli, C., Grob, M., Karli, U.O., Heumann, R., Thoenen, H., Bookman, J., Burger, M. (1989): Inhibition of exocytosis by intracellularly applied antibodies against chromaffin granule-binding protein. Nature 339: 709–712.

    Article  PubMed  CAS  Google Scholar 

  81. Dekker, L.V., De Graan, P.N., Oestreicher, A.B., Versteeg, D.H.G, Gispen, W.H. (1989): Inhibition of noradrenaline release by antibodies to B 50 (GAP-43). Nature 342, 74–76.

    Article  PubMed  CAS  Google Scholar 

  82. Burgoyne, R.B., Cheek, T.R. (1987): Reorganization of peripheral actin filaments as a prelude to exocytosis. Biosci. Rep. 7: 281–288.

    Article  PubMed  CAS  Google Scholar 

  83. Perrin, D., Langley, O.K., Aunis, D. (1987): Anti-α-fodrin inhibits secretion from permeabilized chromaffin cells. Nature 326: 498–501.

    Article  PubMed  CAS  Google Scholar 

  84. Burgoyne, R.D. (1987): G proteins. Control of exocytosis. Nature 328: 112–113.

    Article  PubMed  CAS  Google Scholar 

  85. Burgoyne, R.D. (1988): Calpactin in exocytosis? Nature 331: 20.

    Article  PubMed  CAS  Google Scholar 

  86. Penner, R., Neher, E. (1989): The patch-clamp technique in the study of secretion. TINS 12: 159–163.

    PubMed  CAS  Google Scholar 

  87. Gill, D.L (1989): Receptor kinships revealed. Nature 342: 16–18.

    Article  PubMed  CAS  Google Scholar 

  88. Berridge, M.J., Irvine, R.F. (1989): Inositol phosphates and cell signalling. Nature 341: 197–205.

    Article  PubMed  CAS  Google Scholar 

  89. Benowitz, L.T., Routtenberg, A.: TINS 10: 527–532.

    Google Scholar 

  90. Stumpo, D.J., Graff, J.M., Albert, K.A., Greengard, P., Blackshear, P.J. (1989): Molecular cloning, characterization, and expression of a cDNA encoding the “80-to 87-kDa” myristoylated alanine-rich C kinase substrate: A major cellular substrate for protein kinase C. Proc. Natl. Acad. Sci. USA 86: 4012–4016.

    Article  PubMed  CAS  Google Scholar 

  91. Nishizuka, Y (1986): Studies and perspectives of protein kinase C. Science 233: 305–312.

    Article  PubMed  CAS  Google Scholar 

  92. Aderem, A.A., Albert, K.A., Keum, MM, Wang, J.K.T,. Greengard, P., Cohn, Z.A. (1988): Stimulusdependent myristoylation of a major substrate for protein kinase C. Nature 332: 362–364.

    Article  PubMed  CAS  Google Scholar 

  93. Gray, D.B., Pilar, G.R., Ford, M.J. (1989): Opiate and peptide inhibition of transmitter release in parasympathetic nerve terminals. J. Neurosci. 9: 1683–1692.

    PubMed  CAS  Google Scholar 

  94. Kilbinger, H. (1988): The autonomic cholinergic neuroeffector junction. Handbook Exptl. Pharmacol. 86: 581–614.

    Article  Google Scholar 

  95. Barnard, E.A. (1988): Separating receptor subtypes from their shadows. Nature 355: 301–302.

    Article  Google Scholar 

  96. Nakanishi, S., Ohkubo, H., Masu, Y., Takumi, T., Tamaki, H., Yokota, Y (1989): Molecular characterization of neuropeptide receptors and of a novel membrane protein involved in K+ permeation. In: Maelicke, A. (ed.): Molecular Biology of Ion Channels, NATO ASI Series H: Cell Biology, Vol. 32, Springer. Berlin, Heidelberg, New York, London, Paris, Tokyo. pp. 269–277.

    Google Scholar 

  97. O’Dowd, B.F., Lefkowitz, R.J., Caron, M.G. (1989): Structure of the adrenergic and related receptors. Ann. Rev. Neurosci. 12: 67–83.

    Article  PubMed  Google Scholar 

  98. Witzemann, V., Sakmann, B. (1988): Mechanisms of regulating the expression and function of acetylcholine receptor. *, 453-461.

    Google Scholar 

  99. Darlison, M.G., Hicks, A.A., Cockcroft, V.B., Squire, M.D., Barnard, E.A. (1988): Brain α-neurotoxinbinding proteins and nicotinic acetylcholine receptors. *, 475-492.

    Google Scholar 

  100. Maelicke, A., Fels, G., Plümer-Wilk, R. (1988): Antibodies as probes of the structure of the nicotinic acetylcholine receptor. *, 463-473.

    Google Scholar 

  101. Steinbach, J.H., Ifune, C. (1989): How many kinds of nicotinic acetylcholine receptors are there? TINS 12: 3–6.

    PubMed  CAS  Google Scholar 

  102. Sher, E., Gotti, C., Fornasari, D., Chini, B., Ogando, A.E., Clementi, F. (1988): Human neuroblastoma cells: an in vitro model for the study of mammalian nicotinic receptors. *, 493-506.

    Google Scholar 

  103. Steinbach, J.H. (1989): Structural and functional diversity in vertebrate skeletal muscle nicotinic acetylcholine receptors. Ann. Rev. Physiol. 51: 353–365.

    Article  CAS  Google Scholar 

  104. Zopf, D., Grenningloh, G., Hermans-Borgmeyer, I., Rienitz, A., Becker, C.-M., Schmitt, B., Gundelfinger, E.D., Betz, H. (1988): Molecular biology approaches to the function and development of CNS synapses.*, 507-525.

    Google Scholar 

  105. Barnard, E.A., Darlison, M.G., Seeburg, P. (1987): Molecular biology of the GABAA receptor: the receptor/channel superfamily. TINS 10: 502–509.

    CAS  Google Scholar 

  106. Akagi, H., Miledi, R. (1988): Heterogeneity of glycine receptors and their messenger RNAs in rat brain and spinal cord. Science 242: 270–273.

    Article  PubMed  CAS  Google Scholar 

  107. Gilman, A.F (1987): G proteins: transducers of receptor-generated signals. Ann. Rev. Biochem. 56: 615–649.

    Article  PubMed  CAS  Google Scholar 

  108. Peralta, G., Winslow, J.W., Peterson, G.L., Smith, D.H., Ashkenazi, A., Ramachandran, J., Schimerlik, M.I., Capon, D.J. (1987): Primary structure and biochemical properties of an M2 muscarinic receptor. Science 236: 600–605.

    Article  PubMed  CAS  Google Scholar 

  109. Frielle, T., Kobilka, B., Lefkowitz, R.J., Caron, M.G. (1988): Human β1 and β2-adrenergic receptors: structurally and functionally related receptors derived from distinct genes. TINS 11: 321–324.

    PubMed  CAS  Google Scholar 

  110. Peterson, G.L. (1989): Consensus residues at the acetylcholine binding site of cholinergic proteins. J. Neurosci. Res. 22: 488–503.

    Article  PubMed  CAS  Google Scholar 

  111. MacDermott, A.B., Dale, N. (1987): Receptors, ion channels and synaptic potentials underlying the integrative actions of excitatory amino acids. TINS 10: 280–284.

    CAS  Google Scholar 

  112. Collingridge, L., Bliss, T.V.P. (1987): NMDA receptors-their role in long-term potentiation. TINS 10: 288–293.

    CAS  Google Scholar 

  113. Sladeczek, F., Recasens, M., Bockaert, J. (1988): A new mechanism for glutamate receptor action: phosphoinositide hydrolysis. TINS 11: 545–549.

    PubMed  CAS  Google Scholar 

  114. Gordon, J.L. (1986): Extracellular ATP: effects, sources and fate. Biochem. J. 233: 309–319.

    PubMed  CAS  Google Scholar 

  115. Benham, C.D., Bolton, T.B., Byrne, N.G., Large, W.A. (1987): Action of externally applied adenosine triphosphate on single smooth muscle cells dispersed from rabbit ear artery. J. Physiol. (Lond) 387: 473–488.

    CAS  Google Scholar 

  116. Friel, D.D. (1988): An ATP-sensitive conductance in single smooth muscle cells from rat vas deferens. J. Physiol. (Lond) 401: 361–380.

    CAS  Google Scholar 

  117. Legssyer, A., Poggiolo, J., Renard, D., Vassort, G. (1988): ATP and other adenine compounds increase mechanical activity and inositol trisphosphate production in rat heart. J. Physiol. (Lond) 401: 185–199.

    CAS  Google Scholar 

  118. Wierasko, A., Seyfried, T.N. (1989): ATP-induced synaptic potentiation in hippocampal cells. Brain Res. 491: 365–359.

    Google Scholar 

  119. Simon, E.J. (1988): Recent studies on opioid receptors. *, 525-539.

    Google Scholar 

  120. Venter, J.C., Di Porzio, U., Robinson, D.A., Shreeve, S.M., Lai, J., Kerlavage, A.R., Fracek, S.P., Lentes, K.-U., Fraser, C.M. (1988): Evolution of neurotransmitter receptor systems. Prog. Neurobiol. 30: 105–169.

    Article  PubMed  CAS  Google Scholar 

  121. Pfeiffer-Linn, C., Glantz, R.M. (1989): Acetylcholine and GABA mediate opposing actions on neuronal chloride channels in crayfish. Science 245: 1249–1251.

    Article  PubMed  CAS  Google Scholar 

  122. Nakayama, N., Miyajima, N., Arai, K. (1985): Nucleotide sequences STE2 and STE3, cell typespecific sterile genes from Saccharomyces cerevisiae. EMBO J. 4: 2643–2648.

    PubMed  CAS  Google Scholar 

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  1. AK Neurochemie, Zoologisches Institut der J.W. Goethe-Universität, Siesmayerstraße 70, D-6000, Frankfurt am Main, Federal Republic of Germany

    Herbert Zimmermann

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  1. Herbert Zimmermann
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  1. MPI für Experimentelle Medizin, Hermann Rein Str. 3, 3400, Göttingen, Germany

    Volker Neuhoff

  2. School of Life Sciences Dept. of Biology, University of Hull, Hull, HU6 7RX, England

    John Friend

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© 1991 Springer-Verlag Berlin Heidelberg

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Zimmermann, H. (1991). Cellular and Molecular Basis of Synaptic Transmission. In: Neuhoff, V., Friend, J. (eds) Cell to Cell Signals in Plants and Animals. NATO ASI Series, vol 51. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76470-7_10

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  • DOI: https://doi.org/10.1007/978-3-642-76470-7_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76472-1

  • Online ISBN: 978-3-642-76470-7

  • eBook Packages: Springer Book Archive

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