Abstract
For cerebral infarction, potentially effective therapeutic agents include calcium channel antagonists, excitatory amino acid receptor blockers, free radical scavengers, and agents promoting thrombolysis [7], To evaluate these interventions in patients, they must be administered very early after symptom onset, ideally within several hours. The time threshold in humans for irreversible cellular injury following focal cerebral ischemia has not been established. No doubt it will vary depending on the degree of ischemia and its location within the brain. In primates laboratory studies indicate a threshold for neocortex of 3 h or less [9].
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© 1991 Springer-Verlag Berlin Heidelberg
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Brott, T., Haley, E.C., Levy, D., Barsan, W., Broderick, J., Marler, J.R. (1991). Strategies for Early Treatment of Acute Cerebral Infarction. In: Hacke, W., del Zoppo, G.J., Hirschberg, M. (eds) Thrombolytic Therapy in Acute Ischemic Stroke. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76439-4_23
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DOI: https://doi.org/10.1007/978-3-642-76439-4_23
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