Intravenous Recombinant Tissue Plasminogen Activator in Acute Thrombotic Stroke: Study Design, Recanalization, and Clinical Outcome

  • G. J. del Zoppo
  • A. Ferbert
Conference paper

Abstract

The study of the efficacy of thrombolytic agents in the treatment of acute stroke derives from the observation that stroke is typically an atherothrombotic or thromboembolic process [1, 6], Careful intraarterial infusion of the thrombolytic agents urokinase (u-PA) and streptokinase may lead to thrombus dissolution and clinical improvement in selected patients presenting with acute thrombotic or thromboembolic stroke [1, 2–4 7], This experience has provided the practical background for the evaluation of the relatively fibrin specific agent recombinant tissue plasminogen activator (rt-PA) delivered by intravenous infusion. A predominantly two-chain rt-PA preparation (duteplase, Burroughs Wellcome, Beckenham, UK) has been employed in a prospective open multicenter dose-rate safety and efficacy study of thrombolysis m acute thrombotic and thromboembolic stroke.

Keywords

Ischemia Heparin Luminal Neurol Vasculitis 

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • G. J. del Zoppo
    • 1
  • A. Ferbert
    • 2
  1. 1.Department of Molecular and Experimental Medicine and Division of Hematology/ Medical OncologyScripps Clinic and Reasearch FoundationLa JollaUSA
  2. 2.Abteilung NeurologieRheinisch-Westfälische Technische Hochschule AachenAachenGermany

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