Intravenous Recombinant Tissue Plasminogen Activator in Acute Thrombotic Stroke: Study Design, Recanalization, and Clinical Outcome

  • G. J. del Zoppo
  • A. Ferbert
Conference paper


The study of the efficacy of thrombolytic agents in the treatment of acute stroke derives from the observation that stroke is typically an atherothrombotic or thromboembolic process [1, 6], Careful intraarterial infusion of the thrombolytic agents urokinase (u-PA) and streptokinase may lead to thrombus dissolution and clinical improvement in selected patients presenting with acute thrombotic or thromboembolic stroke [1, 2–4 7], This experience has provided the practical background for the evaluation of the relatively fibrin specific agent recombinant tissue plasminogen activator (rt-PA) delivered by intravenous infusion. A predominantly two-chain rt-PA preparation (duteplase, Burroughs Wellcome, Beckenham, UK) has been employed in a prospective open multicenter dose-rate safety and efficacy study of thrombolysis m acute thrombotic and thromboembolic stroke.


Acute Stroke Hemorrhagic Transformation Recombinant Tissue Plasminogen Activator Hemorrhagic Infarction Thromboembolic Stroke 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • G. J. del Zoppo
    • 1
  • A. Ferbert
    • 2
  1. 1.Department of Molecular and Experimental Medicine and Division of Hematology/ Medical OncologyScripps Clinic and Reasearch FoundationLa JollaUSA
  2. 2.Abteilung NeurologieRheinisch-Westfälische Technische Hochschule AachenAachenGermany

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