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Improved Left Ventricular Geometry and Function by Prolonged Nitroglycerin Therapy After Acute Myocardial Infarction

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Chronic Heart Failure

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Abstract

Early therapy with intravenous nitroglycerin during acute myocardial infarction reduces infarct expansion experimentally and clinically [1, 2]. However, the healing process after myocardial infarction takes place over 6 weeks in the dog model, with early expansion and late thinning [3, 4], and even longer in humans [4]. The aim of this study was therefore to test the hypothesis that prolonged reduction of preload and afterload during the healing phase after a first anterior transmural acute myocardial infarction (ATAMI) might further improve left ventricular (LV) geometry and function [5, 6].

Supported in part by a grant from the Canadian Heart Foundation, Ottawa, Ontario. Please note that copyright restrictions prevent release of more data at this time.

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References

  1. Jugdutt BI (1985) Delayed effects of early infarct-limiting therapies on healing after myocardial infarction. Circulation 72: 907–914

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  2. Jugdutt BI, Warnica JW (1988) Intravenous nitroglycerin therapy to limit myocardial infarct size, expansion and complications: Effect of timing, dosage, and infarct location. Circulation 78: 906–919

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  3. Jugdutt BI, Amy RW (1988) Healing after myocardial infarction in the dog: Changes in infarct hydroxyproline and topography. J Am Coll Cardiol 7: 91–102

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  4. Jugdutt BI (1987) Left ventricular rupture threshold during the healing phase after myocardial infarction in the dog. Can J Physiol Pharmacol 65: 307–316

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  5. Michorowski BL, Tymchak WT, Jugdutt BI (1987) Improved left ventricular function and topography by prolonged nitroglycerin therapy after acute myocardial infarction, (abstract) Circulation 76 (Suppl IV): IV–128

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  6. Jugdutt BI, Michorowski BL, Tymchak WJ (1989) Improved left ventricular function and topography by prolonged nitroglycerin therapy after acute myocardial infarction. Z Kardiol 78 (Suppl 2): 127–129

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Authors
  1. B. I. Jugdutt
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  2. B. L. Michorowski
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  3. W. T. Tymchak
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Editor information

Editors and Affiliations

  1. Furkenstrasse 35, D-4630, Bochum (W), Federal Republic of Germany

    Herbert Viefhues

  2. Institut für Medizinische Soziologie, Westfälische Wilhelms-Universität, Domagkstrasse 3, D-4400, Münster (W), Federal Republic of Germany

    Wolfgang Schoene

  3. Medizinische Forschung, Schwarz Pharma AG, Alfred-Nobel-Strasse 10, D-4019, Monheim (W), Federal Republic of Germany

    R. Rychlik

  4. Cedars-Sinai Medical Center, University of California, 8635 W. Third Street, Suite 1080 W., 90048, Los Angeles, CA, USA

    Asher Kimchi

  5. Cardiology Department, Lady Davis Carmel Hospital, 7 Michal Street, 34362, Haifa, Israel

    Basil S. Lewis

  6. International Medical Affairs, Schwarz Pharma AG, Alfred-Nobel-Strasse 10, D-4019, Monheim (W), Federal Republic of Germany

    Marija Weiss

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© 1991 Springer-Verlag Berlin Heidelberg

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Jugdutt, B.I., Michorowski, B.L., Tymchak, W.T. (1991). Improved Left Ventricular Geometry and Function by Prolonged Nitroglycerin Therapy After Acute Myocardial Infarction. In: Viefhues, H., Schoene, W., Rychlik, R., Kimchi, A., Lewis, B.S., Weiss, M. (eds) Chronic Heart Failure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76433-2_20

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  • DOI: https://doi.org/10.1007/978-3-642-76433-2_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76435-6

  • Online ISBN: 978-3-642-76433-2

  • eBook Packages: Springer Book Archive

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