Effects of Isosorbide-5-Mononitrate on Haemodynamics and Exercise Tolerance in Patients with Heart Failure: Comparisons with Digoxin and Placebo
The pre-eminence of diuretics as first-line treatment in heart failure remains virtually unchallenged but there is less certainty concerning the drugs available for second-line treatment. The longest established of these is the inotrope digoxin, but its efficacy in heart failure with sinus rhythm has recently been called into question [1, 2]. Oral isosorbide dinitrate has also been found to be effective when combined with diuretics in the treatment of heart failure. However, large doses are often required to achieve beneficial acute effects [3, 4].
KeywordsHeart Failure Exercise Tolerance Haemodynamic Effect Left Ventricular Filling Pressure Bicycle Ergometry
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- 1.Gold H, Greiner T, Kwit NT, Otto HL, Warshaw L (1959) Effect of digitalis and diuretics on exertional dyspnoea: study in ambulant patients with chronic heart disease. JAMA 169: 229–236Google Scholar