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Oxygen Carriers as Molecular Models of Allosteric Behavior

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Blood and Tissue Oxygen Carriers

Part of the book series: Advances in Comparative and Environmental Physiology ((COMPARATIVE,volume 13))

Abstract

Cooperative phenomena, in which events at one place determine what happens at another, are best known in physics, with the phenomenon of phase transitions as a classic example. Cooperative phenomena also have an important function in biology that was first defined and analyzed in a seminal paper published a quarter century ago (Monod et al. 1965). The classic example of cooperativity among biological macromolecules is that of the binding of oxygen by hemoglobin. According to simple mass action law, with the assumption that the four oxygen-binding sites on Hb are identical and independent or noninteracting:

$${\text{HbO}_2 \longleftarrow \text{K}_{\text{diss}}\longrightarrow}\text{Hb} +\text{O}_2\;\text{and}\; [\text{Hb}][\text{O}_2]\: =\text{K}_{\text{diss}}[{\text{HbO}_2}]$$
(1)

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Author information

Authors and Affiliations

  1. Duke University Marine Laboratory Beaufort, NC, 28516, USA

    M. Brouwer

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  1. M. Brouwer
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Editors and Affiliations

  1. Department of Biology, The College of William and Mary, Williamsburg, Virginia, 23185, USA

    Charlotte P. Mangum

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© 1992 Springer-Verlag Berlin Heidelberg

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Brouwer, M. (1992). Oxygen Carriers as Molecular Models of Allosteric Behavior. In: Mangum, C.P. (eds) Blood and Tissue Oxygen Carriers. Advances in Comparative and Environmental Physiology, vol 13. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76418-9_1

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  • DOI: https://doi.org/10.1007/978-3-642-76418-9_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76420-2

  • Online ISBN: 978-3-642-76418-9

  • eBook Packages: Springer Book Archive

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