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Proteolysis-Induced Pathomechanisms in Acute Inflammation and Related Therapeutic Approaches

  • Conference paper
Molecular Aspects of Inflammation

Abstract

Proteolysis-induced pathomechanisms seem to play a major role in the primary response of the organism to inflammatory stimuli such as tissue destruction due to multiple trauma and major surgery or invasive microbes and endotoxins in sepsis. Physiologically, the inflammation response is directed towards inactivating and eliminating the deleterious agents and to initiate the process of repair and healing. Yet, the activation of the complex interacting cellular and humoral defence mechanisms necessary for this purpose carries with it also the risk of damaging healthy tissue, thus perpetuating the inflammatory process. In this respect, the lysosomal serine proteinase elastase and the cysteine proteinase cathepsin B of the primary inflammatory cells, polymorphonuclear (PMN) granulocytes, and monocytes/macrophages are supposed to be potent effectors of proteolytic tissue damage if they are discharged extracellularly in high amounts during activation of the phagocytes. Moreover, proteinases of humoral origin (plasma kallikrein, thrombin, plasmin, complement esterases) and protein split products generated by their proteolytic action (fibrinopeptides and fibrin monomers, fibronectin peptides, complement-derived factors such as C3a, C4a, and C5a, etc.) have been proven to be of major importance as strong stimulators of the primary defence cells.

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Author information

Authors and Affiliations

  1. Department of Clinical Chemistry and Clinical Biochemistry, Surgical Clinic City of the University of Munich, Nußbaumstraße 20, D-8000, Munich 2, Germany

    M. Jochum & H. Fritz

  2. Institute of Physiological Chemistry, Physical Biochemistry and Cell Biology of the University of Munich, Goethestraße 33, D-8000, Munich 2, Germany

    W. Machleidt

Authors
  1. M. Jochum
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  2. W. Machleidt
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  3. H. Fritz
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Editor information

Editors and Affiliations

  1. Institut für Physiologische Chemie I, Universität Düsseldorf, Moorenstr. 5, 4000, Düsseldorf, Germany

    Helmut Sies

  2. Gesellschaft für Biotechnologische Forschung, Mascheroder Weg 1, 3300, Braunschweig, Germany

    Leopold Flohé

  3. Gustav-Embden-Zentrum der Biologischen Chemie, Universität Frankfurt, Theodor-Stern-Kai 7, 6000, Frankfurt am Main, Germany

    Guido Zimmer

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© 1991 Springer-Verlag Berlin Heidelberg

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Jochum, M., Machleidt, W., Fritz, H. (1991). Proteolysis-Induced Pathomechanisms in Acute Inflammation and Related Therapeutic Approaches. In: Sies, H., Flohé, L., Zimmer, G. (eds) Molecular Aspects of Inflammation. Colloquium der Gesellschaft für Biologische Chemie 11.–13. April 1991 in Mosbach/Baden, vol 42. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76412-7_7

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  • DOI: https://doi.org/10.1007/978-3-642-76412-7_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76414-1

  • Online ISBN: 978-3-642-76412-7

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