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Central Baroreceptor Reflex Pathways

  • Chapter
Baroreceptor Reflexes

Abstract

Since the first description of terminal endings of vagal and glossopharyngeal afferent fibres in dorsal, medial, and ventral subnuclei of the solitary tract by Cajal [23] numerous morphological and electrophysiological data on this subject have been published (for reference see [168]). As far as the projection of baroreceptor afferents within vagal and glossopharyngeal nerves is concerned most of these studies have been confronted with the problem that not only baroreceptor afferents are present. Even with the new tracer method of transganglionic transport of horseradish peroxidase (HRP) applied to the carotid sinus nerve in the cat [13,40,138] or rat [159] or the aortic nerve in the cat [81], the results must include baro- as well as chemoreceptor afferents. If consideration is restricted to those cases in which a pure baroreceptor nerve can be isolated, e.g., the aortic nerve of the rabbit [184] in which single, functionally identified baroreceptor afferent fibres were stained by HRP [35], then there is general agreement as to the location of terminal endings on the ipsilateral side of the medulla within the dorsomedial region of the solitary tract immediately ventral to the gracile nucleus, the medial solitary nucleus and the commissural nucleus. The highest density of terminal endings is located at the level of the obex. In the rabbit these endings can be demonstrated up to about 1.5 mm cranial and 0.5 mm caudal to the obex. Branches of the afferent fibres cross immediately caudal to the obex, and dorsal to the central canal, in the commissural nucleus of the contralateral site. As described by Cajal, “afferent fibres from the solitary tract do not enter motor nuclei” [23], and the terminal endings of baroreceptor afferents do not project to the dorsal motor nucleus of the vagus or the nucleus ambiguus [184] (Fig. 1).

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Seller, H. (1991). Central Baroreceptor Reflex Pathways. In: Persson, P.B., Kirchheim, H.R. (eds) Baroreceptor Reflexes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76366-3_3

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