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Biological Actions of CCK in the Central Nervous System

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Cholecystokinin Antagonists in Gastroenterology

Abstract

Cholecystokinin (CCK), a gastrointestinal hormone [37], mediates digestive functions and feeding behaviors. Vanderhaeghen et al. [67] demonstrated the presence of gastrin-like immunoreactivity in mammalian brain, and subsequent studies indicate that the majority of this immunoreactivity could be attributed to CCK. Although a large peptide containing 58 amino acid (CCK58) is the major circulating form of CCK in humans and dogs [21,23], the predominant molecular form of CCK in the brain is CCK8 (CCK26–33, the eight amino acids at the C terminus of CCK), which contains a sulfated tyrosine residue [14,54]. However, the unsulfated form (CCK8US) has been detected, in addition to CCK4 [54]. Overall, CCK33 is only present in the brain in small (2%-5% of CCK immunoreactivity) amounts [54].

The research was supported by USPHS Grants MH-41440 and MH-00378 to RYW. CRA was supported by NRSA MH-09791.

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  1. Department of Psychiatry and Behavioral Science State University of New York at Stony Brook Putnam Hall, South Campus Stony Brook, NY, 11794-8790, USA

    C. R. Ashby Jr.

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  1. Abteilung Innere Medizin I, Medizinische Klinik und Poliklinik Oberer Eselsberg, Robert-Koch-Straße 8, W-7900, Ulm, Germany

    Guido Adler

  2. Abteilung für Gastroenterologie, Universitätsklinik, Petersgraben 6, 4031, Basel, Switzerland

    Christoph Beglinger

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Wang, R.Y., Ashby, C.R. (1991). Biological Actions of CCK in the Central Nervous System. In: Adler, G., Beglinger, C. (eds) Cholecystokinin Antagonists in Gastroenterology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76362-5_5

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