Abstract
Homology between biological objects (DNA sequences, species, etc.) can be measured by genetic distance data. A genetic distance may be computed from aligned genetic sequence data; e.g. DNA sequences. We discuss the dot-matrix plot as a possible graphical check of the goodness of the alignment. The assumption of identical distributions along the sequence positions is often inappropriate. Therefore, we discuss aspects of an heuristic which allows the combined exploration of genetic distance between the sequences and of different positional variation. A tree structure is not assumed for such an exploration. Having computed a genetic distance, phylogenetic relations may be analysed by three- and four-objects methods. The approach is illustrated by a set of tRNA sequences.
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Lausen, B. (1991). Statistical Analysis of Genetic Distance Data. In: Bock, HH., Ihm, P. (eds) Classification, Data Analysis, and Knowledge Organization. Studies in Classification, Data Analysis, and Knowledge Organization. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76307-6_34
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DOI: https://doi.org/10.1007/978-3-642-76307-6_34
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-53483-9
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