An Immunosuppressive Factor Sharing Homology with the p15E Protein of Leukomogenic Retroviruses is Present in the Serum of Patients with Graves’ Disease
Approximately 30% of CD14+ and nonspecific esterase-positive cells from the blood monocytic pool are able to differentiate into cells with a morphology and marker pattern of dendritic cells when cultured under nonadhering conditions. An exposure of the cells to metrizamide or thyroid hormones prior to the culture period enhances this differentiation step, and 40%–60% of cells with a dendritic morphology and marker pattern are obtained. The induced dendritic cells are functionally active, which is indicated by the fact that the cell population containing the dendritic cells has an enhanced stimulator capacity in mixed leukocyte reactions and an increased cluster capacity .
KeywordsDendritic Cell Autoimmune Thyroiditis Serum Fraction Mixed Leukocyte Reaction Monocyte Chemotaxis
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