T Cell Epitopes and Thyroid Peroxidase

  • N. Fukuma
  • S. McLachlan
  • D. I. W. Phillips
  • C. A. S. Pegg
  • B. Rapoport
  • B. Rees Smith
Conference paper


Investigations of immune responses to exogenous antigens suggest that antibodies tend to interact with conformational, non-linear regions of polypeptides whereas T cells recognize short, lenear amino acid sequences of denatured antigen in association with MHC molecules. Further, detailed analyses of peptides stimulatory for T cells have indicated that such T cell “epitopes” have characteristic patterns of amino acids which may be predicted according to the algorithms of Rothbard [1] or Berzofsky [2].


Cell Epitope Stimulation Index Autoimmune Thyroid Disease Control Peptide Thyroid Peroxidase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • N. Fukuma
  • S. McLachlan
  • D. I. W. Phillips
  • C. A. S. Pegg
  • B. Rapoport
  • B. Rees Smith

There are no affiliations available

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