T Cell Epitopes and Thyroid Peroxidase

  • N. Fukuma
  • S. McLachlan
  • D. I. W. Phillips
  • C. A. S. Pegg
  • B. Rapoport
  • B. Rees Smith
Conference paper

Abstract

Investigations of immune responses to exogenous antigens suggest that antibodies tend to interact with conformational, non-linear regions of polypeptides whereas T cells recognize short, lenear amino acid sequences of denatured antigen in association with MHC molecules. Further, detailed analyses of peptides stimulatory for T cells have indicated that such T cell “epitopes” have characteristic patterns of amino acids which may be predicted according to the algorithms of Rothbard [1] or Berzofsky [2].

Keywords

Polypeptide Histidine Acetylcholine Thymidine Tetanus 

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References

  1. 1.
    Rothbard JB, Taylor NR (1988) A sequence pattern common to T cell epitopes. EMBO J1: 93–100Google Scholar
  2. 2.
    De Lisi C, Berzofsky JA (1985) T cell antigenic sites tend to be amphipathic structures. Proc Natl Acad Sci USA 82:7048–7052CrossRefGoogle Scholar
  3. 3.
    Fukuma N, McLachlan SM, Rapoport B et al. (1990) Thyroid autoantigens and human T cell responses. Clin Exp Immunol (In press)Google Scholar
  4. 4.
    McLachlan SM, Rapoport B (1989) Evidence for a potential common T cell epitope between human thyroid peroxidase and human thyroglobulin with implications for the pathogenesis of autoimmune thyroid disease. Autoimmunity 5:101–106PubMedCrossRefGoogle Scholar
  5. 5.
    Kovacs J, Kim S, Holleran E, Gerycki P (1985) Studies on the racemization and coupling of Nα, Nim-protected histidine active ests. J Org Chem 50:1497–1504CrossRefGoogle Scholar
  6. 6.
    Schardt CW, McLachlan SM, Metheson J, Rees Smith B (1982) An enzyme-linked immunoassay for thyroid microsomal antibodies. J Immunol Methods 55:155–168PubMedCrossRefGoogle Scholar
  7. 7.
    McLachlan SM, Pegg CAS, Atherton MC, Middleton SL, Dickinson A, Clark F, Proctor SJ, Proud G, Rees Smith B (1986) Subpopulations of thyroid autoantibody secreting lymphocytes in Graves’ and Hashimoto thyroid glands. Clin Exp Immunol 65:319–328PubMedGoogle Scholar
  8. 8.
    McLachlan SM, Clark S, Stimson WH, Clark F, Rees Smith B (1982) Studies of thyroglobulin autoantibody synthesis using a micro-ELISA assay. Immunol Lett 4:27–33PubMedCrossRefGoogle Scholar
  9. 9.
    Farrant J, Bryant AE, Chan J, Himsworth RL (1986) Thyroglobulin-treated blood dendritic cells induce IgG anti-thyroglobulin antibody in vitro in Hashimoto’s thyroiditis. Clin Immunol Immunopathol 41:433–442PubMedCrossRefGoogle Scholar
  10. 10.
    Lanzavecchia A (1985) Antigen-specific interaction between T and B cells. Nature 314: 517CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • N. Fukuma
  • S. McLachlan
  • D. I. W. Phillips
  • C. A. S. Pegg
  • B. Rapoport
  • B. Rees Smith

There are no affiliations available

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