The Endocrinological Basis for Hormonal Therapy of Prostate Tumours

  • M. Motta
Conference paper
Part of the ESO Monographs book series (ESO MONOGRAPHS)


The growth and the activity of the normal prostate is largely dependent upon androgens, a characteristic that is frequently retained (80% of all cases of prostatic cancer) by the prostatic cells which develop into neoplastic cells (either benign: benign prostatic hypertrophy, BPH, or malignant: prostatic carcinoma). This concept is supported by the fact that the lack of testicular function (either due to castration or to hypopituitarism prior to the age of 40) prevents the occurrence of prostatic tumours in males over 55 years of age. It has been reported that the members of a Russian sect who undergo ritual castration before the age of 35 never exhibit the symptoms of BPH and have a prostate smaller than normal (see [1] for review).


Growth Hormone Adrenal Androgen Cyproterone Acetate LHRH Agonist Prostatic Growth 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • M. Motta
    • 1
  1. 1.Department of EndocrinologyUniversity of MilanoMilanoItaly

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