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Contribution of HM-PAO-SPECT and 133Xe-rCBF to the Differential Diagnosis of Dementia as Experienced in Clinical Practice

  • R. Horn
  • R. Erkwoh
  • K. Broich
  • I. Hasse-Sander
  • F. Grünwald
  • H. J. Biersack
  • L. Solymosi
  • F. Ries
  • H. J. Möller
Conference paper

Abstract

The measurement of regional cerebral blood flow (rCBF) by the mTc-hexamethyl-propylenamineoxime single photon emission computer tomography (HM-PAO-SPECT) and 133Xe inhalation methods is usually described as facilitating the clinical diagnosis of Alzheimer’s disease, which is difficult to diagnose with certainty. In particular, substantial rCBF abnormalities have been reported in patients in the early stages of this disease, when differential diagnosis is most critical. Prohovnik et al. (1988) reported a more than 90% correct classification in a group of elderly healthy controls and a group of patients with the early stage of this disease. It is also said that these two procedures can be used to differentiate between various forms of dementia, especially of the Alzheimer type (DAT) and multi-infarct dementia (MID) patients (Burns, Risberg, Deisenhammer, Weinstein, Gemmell). Some authors found significant correlations between the rCBF and the results of neuropsychological tests (Burns, Broich), while others found none (Perani).

Keywords

Interference Test Single Photon Emission Computer Tomography Laboratory Blood Test Elderly Healthy Control Selective Remind Test 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • R. Horn
    • 1
  • R. Erkwoh
    • 1
  • K. Broich
    • 1
  • I. Hasse-Sander
    • 1
  • F. Grünwald
    • 1
  • H. J. Biersack
    • 1
  • L. Solymosi
    • 1
  • F. Ries
    • 1
  • H. J. Möller
    • 1
  1. 1.Psychiatric Department of the University of BonnBonn 1Germany

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