Cerebral Ischemia Correlates Better with Cognitive Impairments in Mild to Moderate Multi-Infarct Dementia than Infarcted Brain Volume
Hachinski et al. suggested the term “multi-infarct dementia” (MID) for demented patients whose cognitive impairments resulted from multiple bilateral ischemic strokes based on clinical and neuropathological studies . This terminology has now become standard for patients with vascular damentia due to ischemic strokes . Among patients with MID, evidence has been adduced that control of risk factors and platelet anti-aggregant therapy prevents recurrent strokes and stabilizes or enhances recovery from MID [12,13,15]. At the present time, accepted methods for prevention and treatment of Alzheimer’s disease are not available. Hence, quantitative assessments of cerebral ischemia and infarction among patients with dementia is an important consideration.
KeywordsCerebral Ischemia Infarcted Brain Cortical Gray Matter Local Cerebral Blood Flow Arterial Territory
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