Advertisement

Improved Learning with N-Methyl-D-aspartate Receptor Antagonist After Global Cerebral Ischemia

  • T. J. DeGraba
  • J. C. Grotta
  • C. M. Picone
  • P. T. Ostrow
  • R. A. Strong
  • R. M. Earls
  • L. P. Yao
  • H. M. Rhoades
  • J. R. Dedman
Conference paper

Abstract

Activation of N-methyl-D-aspartate (NMDA) receptors by ischemia-induced glutamate release results in the entry of ionic calcium into neurons, followed by progressive neuronal damage by calcium-activated enzyme systems and delayed cell death. Earlier studies using excitatory neurotransmitter antagonists have demonstrated neuronal protection against ischemia, raising the possibility that these drugs can be used effectively in the therapy of acute stroke. When evaluating the effectiveness of a drug for use in cases of acute stroke however, it is important to demonstrate functional as well as histological improvement.

Keywords

Global Ischemia Global Cerebral Ischemia Ischemic Animal Improve Learn Ischemic Control 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • T. J. DeGraba
    • 1
  • J. C. Grotta
    • 1
  • C. M. Picone
    • 1
  • P. T. Ostrow
    • 1
  • R. A. Strong
    • 1
  • R. M. Earls
    • 1
  • L. P. Yao
    • 1
  • H. M. Rhoades
    • 1
  • J. R. Dedman
    • 1
  1. 1.Department of NeurologyUniversity of TexasHoustonUSA

Personalised recommendations