Improved Learning with N-Methyl-D-aspartate Receptor Antagonist After Global Cerebral Ischemia
Activation of N-methyl-D-aspartate (NMDA) receptors by ischemia-induced glutamate release results in the entry of ionic calcium into neurons, followed by progressive neuronal damage by calcium-activated enzyme systems and delayed cell death. Earlier studies using excitatory neurotransmitter antagonists have demonstrated neuronal protection against ischemia, raising the possibility that these drugs can be used effectively in the therapy of acute stroke. When evaluating the effectiveness of a drug for use in cases of acute stroke however, it is important to demonstrate functional as well as histological improvement.
KeywordsGlobal Ischemia Global Cerebral Ischemia Ischemic Animal Improve Learn Ischemic Control
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