Advertisement

RBC Aggregation Is Not a Primary Factor for Microvascular Stasis on Temporary Complete Ischemia of the Feline Brain

  • M. Tomita
  • F. Gotoh
  • N. Tanahashi
  • M. Kobari
  • T. Shinohara
  • T. Yamakawi
  • Y. Terayama
  • B. Mihara
  • K. Ohta
  • H. Takeda

Abstract

Vascular dementia could be triggered by cerebral ischemia, in which micro-circulatory stasis and subsequent impairment of microcirculation may constitute the cardinal events. The possibility that aggregation of red blood cells (RBC) might contribute to the stasis and no-reflow has been suggested for many years, since the viscosity of blood in a sluggish flow or stasis is predicted to increase from the hemorrheological viewpoint. We examined the effect of RBC aggregation in the leptomeningeal vessels and parenchymal microvasculature on reflow after a brief, complete interruption of flow through the brain tissue produced by cardiac arrest.

Keywords

Cerebral Blood Flow Cardiac Arrest Mean Arterial Blood Pressure Cerebral Blood Volume Mean Transit Time 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Tomita M, Gotoh F, Sato T, Amano T, Tanahashi N, Tanaka K, Yamamoto M (1978) Photoelectric method for estimating hemodynamic changes in regional cerebral tissue. Am J Physiol 235:H56–H63PubMedGoogle Scholar
  2. 2.
    Yamawaki T, Gotoh F, Tomita M, Tanahashi N, Kobari M, Shinohara T, Terayama Y, Mihara B, Ohta K (1989) Degree of RBC aggregation in the pial vessels during cardiac arrest in cats. Abstr. 1st International Stroke Congress, Kyoto, OS-10–09Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • M. Tomita
    • 1
  • F. Gotoh
    • 1
  • N. Tanahashi
    • 1
  • M. Kobari
    • 1
  • T. Shinohara
    • 1
  • T. Yamakawi
    • 1
  • Y. Terayama
    • 1
  • B. Mihara
    • 1
  • K. Ohta
    • 1
  • H. Takeda
    • 1
  1. 1.Department of Neurology, School of MedicineKeio UniversityTokyo 160Japan

Personalised recommendations