RBC Aggregation Is Not a Primary Factor for Microvascular Stasis on Temporary Complete Ischemia of the Feline Brain
Vascular dementia could be triggered by cerebral ischemia, in which micro-circulatory stasis and subsequent impairment of microcirculation may constitute the cardinal events. The possibility that aggregation of red blood cells (RBC) might contribute to the stasis and no-reflow has been suggested for many years, since the viscosity of blood in a sluggish flow or stasis is predicted to increase from the hemorrheological viewpoint. We examined the effect of RBC aggregation in the leptomeningeal vessels and parenchymal microvasculature on reflow after a brief, complete interruption of flow through the brain tissue produced by cardiac arrest.
KeywordsCerebral Blood Flow Cardiac Arrest Mean Arterial Blood Pressure Cerebral Blood Volume Mean Transit Time
Unable to display preview. Download preview PDF.
- 2.Yamawaki T, Gotoh F, Tomita M, Tanahashi N, Kobari M, Shinohara T, Terayama Y, Mihara B, Ohta K (1989) Degree of RBC aggregation in the pial vessels during cardiac arrest in cats. Abstr. 1st International Stroke Congress, Kyoto, OS-10–09Google Scholar