Glutamate: A Role in Both Cerebral Ischaemia and Dementia of the Alzheimer Type

  • D. Dewar
  • R. Bullock
  • D. T. Chalmers
  • D. I. Graham
  • J. McCulloch
Conference paper


Glutamate has two major roles in the CNS under normal circumstances. As well as being involved in intermediary metabolism, this amino acid is the major excitatory neurotransmitter in the cerebral cortex, mediating both corticocortical and corticofugal transmission. In addition to these physiological roles for glutamate in the normal brain, its neurotoxic actions have been known for many years. Glutamate neurotoxicity has been implicated in the pathophysiology of a variety of neurodegenerative conditions, including cerebral ischaemia, dementia of the Alzheimer type (DAT), Huntington’s chorea and epilepsy. The evidence supporting glutamate-induced neuronal death in the last three conditions is at present somewhat circumstantial. However, there is convincing experimental evidence for glutamate neurotoxicity in cerebral ischaemia. Extracellular concentrations of glutamate are markedly elevated in cerebral ischaemia [2,5,14, 16], and specific glutamate antagonists have neuroprotective effects [34,35,38].


NMDA Receptor Cerebral Ischaemia Middle Cerebral Artery Occlusion Focal Cerebral Ischaemia Cereb Blood Flow 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • D. Dewar
    • 1
  • R. Bullock
    • 1
  • D. T. Chalmers
    • 1
  • D. I. Graham
    • 1
  • J. McCulloch
    • 1
  1. 1.Wellcome Surgical Institute and Hugh Fraser Neuroscience LaboratoriesUniversity of GlasgowGlasgowUK

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