Potential Mechanisms Underlying Protection Against Cerebral Ischemia by Spontaneous Locomotion in Mongolian Gerbils
During recent years the selective vulnerability of discrete brain regions after short episodes of cerebral ischemia has received considerable attention. In the hippocampus, in particular, nerve cell loss may become prominent within only 5 min of ischemia. When this happens neurons appear intact during the initial 1–2 days of reperfusion but succumb later, a phenomenon termed “delayed neuronal death.” In a previous study, we investigated the mechanisms involved in postischemic nerve cell damage and were able to demonstrate that preischemic physical activity may protect experimental animals from damage in the gerbil forebrain ischemia model . Within 15 min of ischemia there was a dramatic enhancement of survival from 44% in controls to 85% in animals which had access to a “running wheel” before experiencing ischemia. The present study was performed in order to evaluate potential mechanisms for this protection.
KeywordsCerebral Ischemia Mongolian Gerbil Forebrain Ischemia Selective Vulnerability Systemic Arterial Blood Pressure
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