Selective Vulnerability of the CA1 Sector in the Gerbil After 5 Minutes of Global Ischemia: Relationship to Disturbances in Protein Synthesis and to Motor Hyperactivity
Transient forebrain ischemia of the gerbil is a widely used experimental model for the study of the phenomenon of selective vulnerability in the CA1 sector of hippocampus. Despite the fact that detailed studies are available on the time course of various hemodynamic , metabolic [5,12,14], and neuropathological alterations [2,6,7], the causal relationship between the pathobiochemical processes and the development of neuronal death is still poorly understood.
KeywordsDepression Ischemia Dementia Neurol Paraffin
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- 3.Crain BJ, Westerkam WD, Harrison AH, Nadler JV (1988) Selective neuronal death after transient forebrain ischemia in the mongolian gerbil: a silver impregnation study. Neuroscience 22:387–402Google Scholar
- 9.Kuroiwa T, Bonnekoh P, Hossmann KA (1990) Therapeutic window of halothane anesthesia for reversal of delayed neuronal injury in gerbils relationship to post-ischemic motor hyperactivity. (In preparation)Google Scholar
- 10.Loskota WJ, Lomax P, Verity MA (1974) A stereotaxic atlas of the mongolian gerbil brain. Ann Arbor Science, Ann ArborGoogle Scholar
- 12.Munekata K, Hossmann KA, Xie Y, Seo K, Oschlies U (1987) Selective vulnerability of hippocampus ribosomal aggregation, protein synthesis, and tissue pH. In: Raichle ME, Powers WJ (eds) Cerebrovascular diseases, Raven, New York, pp 107–118Google Scholar
- 18.Vass K, Welch WJ, Nowak TS (1988) Localization of 70-kDa stress protein induction in gerbil brain after ischemia. Acta Neuropathol (Berl) 77:128–135Google Scholar
- 19.Widmann R, Kuroiwa T, Bonnekoh P, Hossmann KA (1990) 14C Leucine incorporation into brain proteins in gerbils after transient ischemia relationship to selectively vulnerability of hippocampus. J Neurochem (submitted)Google Scholar