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Endothelial Cells and Dendritic Cells in Rheumatoid Inflammation

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Rheumatoid Arthritis

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Abstract

Endothelial cells (EC) and dendritic cells (DC) play an important role in rheumatoid inflammation. All types of inflammatory cells seem to emigrate to the synovial tissue by first binding to the high endothelial venules. Certain cytokines increase this binding and direct the cell traffic to the inflammatory sites. Interferon-γ stimulates EC to express HLA class-II molecules and to become accessory cells for T-cell activation. The dendritic cells are probably the most important accessory cells for the T-cell responses in the inflamed joint tissues. This is accomplished by their strong HLA class-II antigen expression, their large surface area, and their production of cytokines.

This work was supported by grants from the Norma and Leon Hess Foundation for Research on Rheumatological Diseases, the Norwegian Women’s Public Health Organization, the Grethe Harbitz Legacy, the Norwegian Research Council for Science and the Humanities and Hafslund Nycomed, Norway.

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  1. K. Waalen

    Present address: Department of Animal Genetics, Norwegian College of Veterinary Medicine, Oslo, Norway

Authors and Affiliations

  1. Oslo Sanitetsforenings Rheumatism Hospital, the National Hospital, Oslo, Norway

    Ø. Førre

  2. Institute of Immunology and Rheumatology, the National Hospital, Oslo, Norway

    J. B. Natvig

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  1. Ø. Førre
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  2. K. Waalen
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  3. J. B. Natvig
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Editor information

Editors and Affiliations

  1. 2. Medizinische Abteilung Zentrum fü Diagnostik und Therapie rheumatischer Erkrankungen, Krankenhaus der Stadt Wien-Lainz und Ludwig Boltzmann Institut für Rheumatologie und Balneologie, Wolkersbergenstraße 1, A-1130, Wien, Austria

    Josef S. Smolen

  2. Medizinische Klinik III mit Poliklinik und Institut für Klinische Immunologie und Rheumatologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Krankenhausstraße 12, W-8520, Erlangen, Germany

    Joachim R. Kalden

  3. Mathilda and Terence Kennedy Institute of Rheumatology, 6 Bute Gardens, W6 7DW, Hammersmith, London, UK

    Ravinder N. Maini

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Førre, Ø., Waalen, K., Natvig, J.B. (1992). Endothelial Cells and Dendritic Cells in Rheumatoid Inflammation. In: Smolen, J.S., Kalden, J.R., Maini, R.N. (eds) Rheumatoid Arthritis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76189-8_6

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  • DOI: https://doi.org/10.1007/978-3-642-76189-8_6

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