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Rheumatoid Arthritis pp 41–54Cite as

Pathogenesis of Rheumatoid Arthritis: Cellular and Cytokine Interactions

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Abstract

Rheumatoid arthritis (RA) is an inflammatory disease with autoimmune features chiefly affecting synovial joints. In more severe cases there are extra-articular and systemic complications. The basic aetiology of this disease is not known, but there is a clear genetic predisposition. This maps clearly, but not exclusively, to the HLA-DR region; however, genetic predisposition is not sufficient to explain the disease, as identical twins are often (~ 50%) discordant [25].

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Author information

Authors and Affiliations

  1. Charing Cross Sunley Research Centre, Lurgan Avenue, Hammersmith, London, W6 8LW, UK

    M. Feldmann & F. M. Brennan

  2. Kennedy Institute of Rheumatology, 6 Bute Gardens, Hammersmith, London, W6 7DW, UK

    M. Field & R. N. Maini

Authors
  1. M. Feldmann
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  2. F. M. Brennan
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  3. M. Field
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  4. R. N. Maini
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Editor information

Editors and Affiliations

  1. 2. Medizinische Abteilung Zentrum fü Diagnostik und Therapie rheumatischer Erkrankungen, Krankenhaus der Stadt Wien-Lainz und Ludwig Boltzmann Institut für Rheumatologie und Balneologie, Wolkersbergenstraße 1, A-1130, Wien, Austria

    Josef S. Smolen

  2. Medizinische Klinik III mit Poliklinik und Institut für Klinische Immunologie und Rheumatologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Krankenhausstraße 12, W-8520, Erlangen, Germany

    Joachim R. Kalden

  3. Mathilda and Terence Kennedy Institute of Rheumatology, 6 Bute Gardens, W6 7DW, Hammersmith, London, UK

    Ravinder N. Maini

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© 1992 Springer-Verlag Berlin Heidelberg

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Feldmann, M., Brennan, F.M., Field, M., Maini, R.N. (1992). Pathogenesis of Rheumatoid Arthritis: Cellular and Cytokine Interactions. In: Smolen, J.S., Kalden, J.R., Maini, R.N. (eds) Rheumatoid Arthritis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76189-8_4

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  • DOI: https://doi.org/10.1007/978-3-642-76189-8_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76191-1

  • Online ISBN: 978-3-642-76189-8

  • eBook Packages: Springer Book Archive

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