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Caprine Arthritis-Encephalitis

  • Conference paper
Rheumatoid Arthritis

Abstract

Caprine arthritis-encephalitis (CAE) is a disease in goats which occurs worldwide [3]. Interest in this disease has increased in recent years mainly for two reasons. CAE virus, also referred to as caprine lentivirus, is a member of the same subfamily as the viruses causing AIDS, the human immunodeficiency viruses (HIV) [14, 76]. CAE, along with other lentiviral infections of domestic animals, shares some of the features of AIDS, such as a long and variable incubation time and lifelong persistence, but differs by not causing immunodeficiency. Moreover, the economic losses caused by CAE have become more obvious and CAE eradication programs have been established in several countries. In this article, we shall consider an additional aspect of CAE, namely the possibility of using this disease as a model for arthritis in humans. This possibility is suggested by the fact that arthritis is the hallmark of CAE. We shall review basic properties of the virus, the disease symptoms and pathological alterations, the epidemiology, and the main aspects of the pathogenesis of CAE. In the concluding section, we shall discuss the possible use of CAE as a model in the study of the mechanisms involved in the pathogenesis of human arthritis.

This work was supported by the Swiss National Science Fund, Grant 31–28810.90 (EP) and 3.879–0.88 (SL).

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Authors and Affiliations

  1. Institute of Veterinary Virology, University of Berne, Länggass-Strasse 122, CH-3012, Berne, Switzerland

    E. Peterhans, B. Pohl & R. Zanoni

  2. Institute of Animal Husbandry, University of Berne, Länggass-Strasse 122, CH-3012, Berne, Switzerland

    S. Lazary

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  1. E. Peterhans
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  2. B. Pohl
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  3. R. Zanoni
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  4. S. Lazary
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Editors and Affiliations

  1. 2. Medizinische Abteilung Zentrum fü Diagnostik und Therapie rheumatischer Erkrankungen, Krankenhaus der Stadt Wien-Lainz und Ludwig Boltzmann Institut für Rheumatologie und Balneologie, Wolkersbergenstraße 1, A-1130, Wien, Austria

    Josef S. Smolen

  2. Medizinische Klinik III mit Poliklinik und Institut für Klinische Immunologie und Rheumatologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Krankenhausstraße 12, W-8520, Erlangen, Germany

    Joachim R. Kalden

  3. Mathilda and Terence Kennedy Institute of Rheumatology, 6 Bute Gardens, W6 7DW, Hammersmith, London, UK

    Ravinder N. Maini

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Peterhans, E., Pohl, B., Zanoni, R., Lazary, S. (1992). Caprine Arthritis-Encephalitis. In: Smolen, J.S., Kalden, J.R., Maini, R.N. (eds) Rheumatoid Arthritis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76189-8_15

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  • DOI: https://doi.org/10.1007/978-3-642-76189-8_15

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