Skip to main content
SpringerLink
Log in

Chemotherapie des Plattenepithelkarzinoms der Speiseröhre im interdisziplinären Konzept

  • Conference paper
Aktuelle Therapie gastrointestinaler Tumoren

Zusammenfassung

Bei der Behandlung von Patienten mit Plattenepithelkarzinom der Speiseröhre bestehen für die Anwendung zytostatisch wirkender Medikamente drei Indikationen:

  • als Palliativmaßnahme bei Patienten mit lokoregionalen Rezidiven und/oder mit Fernmetastasen,

  • bei funktionell operablen Patienten mit lokoregional begrenzten bzw. lokal fortgeschrittenen Primärtumoren im Rahmen einer multimodalen Verbundtherapie als präoperative (neoadjuvante) Therapieoption (alleinige Chemotherapie oder Radio-/Chemotherapie) mit dem Ziel, durch Steigerung der radikalen Resektionen (R0-Resektionen) die Prognose zu verbessern und

  • bei funktionell inoperablen Patienten mit lokoregional begrenzter bzw. lokal fortgeschrittener Tumorausbreitung in Verbindung mit der Strahlentherapie (simultan oder sequentiell).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 64.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 84.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Abbreviations

CR:

komplette Remission

cCR:

komplette Remission klinisch

pCR:

komplette Remission pathologisch-histologisch

PR:

partielle Remission

cPR:

partielle Remission klinisch

95%-VIV:

95% Vertrauensbereich

mR:

Remissionsdauer median

mS:

Überlebenszeit median

mÜZ:

Überlebenszeit median

LRD:

lokoregionale Erkrankung

LFD:

lokal-fortgeschrittene Erkrankung

ED:

extendierte (fortgeschrittene) Erkrankung

ADM:

Adriamycin

BLM:

Bleomycin

CDDCA:

Carboplatin

CDDP:

Cisplatin

5 FU:

5-Fluorouracil

IFOS:

Ifosfamid

MBGB:

Mitoguazone

DCMTX:

Dichloromethotrexat

MTX:

Methotrexat

LEV:

Leucovorin

MMC:

Mitomycin C

VDS:

Vindesin

VBL:

Vinblastin

Literatur

  1. Aapro MS, Hellbardt A, Mirimanoff MD, Achille E, Mégevand R (1990) Neo-adjuvant chemotherapy and radiotherapy for squamous cell carcinoma of the esophagus. In: Adjuvant Therapy of Cancer VI. Salmon SE (ed) W. B. Saunders Company, pp 389–395

    Google Scholar 

  2. Advani SM, Saika TK, Swaropp S, Ramakrishan G, Nair C, Duishaw K, Sharma S, Vyas J, Desai P (1985) Anterior chemotherapy in esophageal cancer. Cancer 56: 1502–1506

    Article  PubMed  CAS  Google Scholar 

  3. Ajani J, McMurtrey M, Rich T, Blackburn R, Chang-Tung E, Faintuch J, Levin B, Mountain C (1987) Combined modality therapy with effective prolonged systemic component for the locally advanced squamous cell carcinoma of the esophagus. Proc Am Soc Clin Oncol 6: 82 (320)

    Google Scholar 

  4. Ajani J, McMurtrey M, Rich TA, Roth JA, Ryan B, DeCaro L, Faintuch JS, Levin B, Mountain C (1990) Study of prolonged chemotherapy for localized squamous cell carcinoma of the esophagus (in preparation)

    Google Scholar 

  5. Ansell SM, Alberts AS, Falkson G (1989) Ifosfamide in advanced carcinoma of the esophagus. A phase II trial with severe toxicity. Am J Clin Oncol 12: 205–207

    Article  PubMed  CAS  Google Scholar 

  6. Bajorin D, Kelsen D, Heelan R (1986) Phase II trial of dichloromethotrexate in epidermoid carcinoma of the esophagus. Cancer Treat Rep 70: 1245–1246

    PubMed  CAS  Google Scholar 

  7. Bedikian A, Valdivieso M, Bodey G (1979) Phase II evaluation of vindesine in the treatment of colorectal and esophageal tumors. Cancer Chemother Pharmacol 2: 263–266

    Article  PubMed  CAS  Google Scholar 

  8. Bedikian A (1984) Phase II evaluation of 5-fluorouracil (F), adriamycin (A), cisplatin (P) and vepesid (Vp-16), FAP-Vp-16 multidrug regimen in patients with esophageal carcinoma. Proc Am Soc Clin Oncol 3:146, Abstr. 571

    Google Scholar 

  9. Bedikian A, Deniord R, El-Akkad S (1987) Value of preoperative chemotherapy for esophageal carcinoma. Proc Am Soc Clin Oncol 6:96, Abstr. 375

    Google Scholar 

  10. Bedikian AY, Deniord R, El-Akkad S (1988) Value of preoperative chemotherapy in the management of locoregional esophageal carcinoma. In: Siewert JR, Hölscher AH (eds) Diseases of the esophagus. Springer, Berlin Heidelberg New York, pp 316–318

    Google Scholar 

  11. Bezwoda W, Derman D, Weaving A, Nissenbaum M (1984) Treatment of esophageal cancer with vindesine: an open trial. Cancer Treatm Rep 68: 783–795

    CAS  Google Scholar 

  12. Bidoli P, Spinazze S, Valente M, Zucali R, Prada A, Gantu G, Ravasi G, Santoro A, Bonadonna G (1990) Combined chemotherapy (CT)-radiotherapy (RT) ± esophagectomy (E) in squamous cell cancer of the esophagus (SCCE). Proc Am Soc Clin Oncol 9:110, Abstr. 424

    Google Scholar 

  13. Bleiberg H, Jacob JH, Bedenne L, Paillot B, DeBesi P, Lacave A (1989) Randomized phase II trial of cisplatin (DDP), 5-fluorouracil (5FU) versus DDP alone in advanced oesophageal cancer. EORTC Symposium Straßburg, November 15–17th

    Google Scholar 

  14. Blum R, Carter S, Agre K (1973) A clinical review of bleomycin: a new antineoplasic agent. Cancer 31: 903–914

    Article  PubMed  CAS  Google Scholar 

  15. Bossett J, Hurterloup P, Bontemas P (1983) A phase II trial of bleomycin and cisplatin in advanced oesophagus carcinoma. Proc 13th Internat Cancer Congress, p41

    Google Scholar 

  16. Campbell WR, Taylor SA, Pierce GE, Hermreck AS, Thomas JH (1985) Therapeutic alternatives in patients with esophageal cancer. Am J Surg 150: 665–668

    Article  PubMed  Google Scholar 

  17. Carey R, Choi N, Hilgenberg A, Grillo H (1985) Preoperative chemotherapy (5FUDDP) as initial component in multimodality treatment program for esophageal cancer. Proc Am Soc Clin Oncol 4:78, Abstr. C-301

    Google Scholar 

  18. Carey R, Hilgenberg A, Wilkins E, Choi N, Mathisen D, Grillo H (1986) Preoperative chemotherapy followed by surgery with possible postoperative radiotherapy in squamous cell carcinoma of the esophagus: evaluation of the chemotherapy component. J Clin Oncol 4: 697–701

    PubMed  CAS  Google Scholar 

  19. Carey RW, Hilgenberg AD, Grillo HC, Mathisen DJ, Choi NC, Logan DL (1990) Esophageal carcinoma: long term follow-up of patients treated by neo-adjuvant chemotherapy, surgery and possible postoperative radiation and/or chemotherapy. Proc Am Soc Clin Oncol 9:105, Abstr. 404

    Google Scholar 

  20. Carter P, Burton G, Wolfe W, Crocker I, Seigler H, Prosnitz L, Crawford J (1989) Squamous cell carcinoma of the esophagus: effective multimodal therapy. Proc Am Soc Clin Oncol 8:104, Abstr. 404

    Google Scholar 

  21. Chan A, Wong A, Arthur K (1989) Concomitant 5-fluorouracil infusion, mitomycin C and radical radiation therapy in esophageal squamous cell carcinoma. Int J Radiation Biol Phys 16: 59–65

    Article  CAS  Google Scholar 

  22. Chapman R, Flemig Th, Damme I, MacDonald J (1987) Cisplatin vinblastine and mitoguazone in squamous cell carcinoma of the esophagus. Cancer Treat Rep 71: 1186–1187

    Google Scholar 

  23. Coia LR, Engstrom PF, Paul A (1987) Nonsurgical management of esophageal cancer: report of a study of combined radiotherapy and chemotherapy. J Clin Oncol 5: 1783–1790

    PubMed  CAS  Google Scholar 

  24. Coonley C, Bains M, Heelan R, Dukeman M, Kelsen D (1983) Phase II study of etoposide in the treatment of esophageal carcinoma. Cancer Treat Rep 67: 397–398

    PubMed  CAS  Google Scholar 

  25. Coonley C, Hilaris B, Bains M, Kelsen DP (1984) Cisplatin-bleomycin in the treatment of esophageal carcinoma: a final report. Cancer 54: 2351–2355

    Article  PubMed  CAS  Google Scholar 

  26. Davis S, Shanmayathasa M, Kessler W (1980) Cis-dichlorodiamineplatinum ( II) in the treatment of esophageal carcinoma. Cancer Treat Rep 64: 709–711

    PubMed  CAS  Google Scholar 

  27. De Besi P, Savagno L, Endrizzi L (1984) Cisplatin, bleomycin and methotrexate in the treatment of advanced esophageal cancer. Eur J Clin Oncol 20: 743–747

    Article  Google Scholar 

  28. De Besi P, Paccagnella A, Chiarion-Sileni V, Salvagno L, Fosser V, Tremolada C, Peraccia A, Fiorentino M (1986) Cisplatin and fluorouracil infusion chemotherapy for advanced squamous esophageal cancer. Proc Am Soc Clin Oncol 5:48, Abstr. 578

    Google Scholar 

  29. De Besi P, Chiarion-Sileni V, Salvagno L, Tremolada C, Cartel G, Fosser V, Paccagnella A, Peraccia A, Fiorentino M (1986) Phase II study of cisplatinum, 5FU and allopurinol in advanced squamous esophageal cancer. Cancer Treat Rep 70: 909–910

    PubMed  Google Scholar 

  30. De Besi P, Salvagno L, Paccagnella A, Toso S, Maretto D, Chiarion-Sileni V, Tremolada C, Peracchia A, Fiorentino M (1987) Cisplatin-combined therapy for advanced squamous esophageal cancer: 5 year experience. Proc Eur Conf Clin Oncol 4: 37 (132)

    Google Scholar 

  31. De Besi P, Chiarion-Sileni V, Salvagno L, Toso S, Paccagnella A, Fosser V, Tremolada C, Peraccia A, Fiorentino M (1988) Systemic chemotherapy with cisplatin, 5-fluorouracil and allopurinol in the management of advanced epidermoid esophageal cancer. In:Schlag P, Hohenberger P, Metzger U (eds) Combined modality therapy of gastrointestinal tract cancer. Springer, Berlin Heidelberg New York, pp 196–197

    Google Scholar 

  32. De Besi P, Toso S, Chiarion-Sileni V, Bardini R, Castoro C, Salvagno L, Paccagnella A, Ruol A, Peraccia A, Fiorentino MV (1990) Multimodality therapy for unresectable squamous cell carcinoma of the esophagus (ESCC). Proc Am Soc Clin Oncol 9:129, Abstr. 500

    Google Scholar 

  33. Dinwoodie W, Bartholucci A, Lyman G, Velez-Garcia E, Martelo O, Sarma P (1986) Phase II evaluation of cisplatin, bleomycin and vindesine in advanced squamous cell carcinoma of the esophagus: a Southeastern Cancer Study Group trial. Cancer Treat Rep 70: 267–270

    PubMed  CAS  Google Scholar 

  34. Earle J, Gelber R, Moertel C et al. (1980) A controlled evaluation of combined radiation and bleomycin therapy for squamous cell carcinoma of the esophagus. Int J Radiat Oncol Biol Phys 6: 821

    Article  PubMed  CAS  Google Scholar 

  35. Engstrom P, Lavin P, Klaassen DD (1983) Phase II evaluation of mitomycin and cisplatin in advanced esophageal carcinoma. Cancer Treat Rep 67: 713–715

    PubMed  CAS  Google Scholar 

  36. Ezdinli E, Gelber R, Desai D, Falkson G, Moertel C, Hahn R (1980) Chemotherapy of advanced esophageal carcinoma: Eastern Cooperative Oncology Group experience. Cancer 46: 2149–2153

    Article  PubMed  CAS  Google Scholar 

  37. Falkson G (1971) Methyl-GAG treatment of esophagus cancer. Cancer Chemother Rep 55: 209–212

    PubMed  CAS  Google Scholar 

  38. Fink U, Gossmann A, Ries G, Siewert JR: Präoperative Radio-/Chemotherapie bei lokal fortgeschrittenen Karzinomen der oberen Hälfte der Speiseröhre (in Vorbereitung)

    Google Scholar 

  39. Forastiere A, Gennis M, Orringer Agha F (1987) Cisplatin, vinblastine and mitoguazone chemotherapy for epidemoid and adenocarcinoma of the esophagus. J Clin Oncol 5: 1143–1149

    PubMed  CAS  Google Scholar 

  40. Forastiere AA, Orringer MB, Perez-Tamayo C, Urba SG, Husted S, Takasugi BJ, Zahurak M (1990) Concurrent chemotherapy and radiation therapy followed by transhiatal esophagectomy for local regional cancer of the esophagus. J Clin Oncol 8: 119–127

    PubMed  CAS  Google Scholar 

  41. Franklin R, Steiger Z, Vaishampayan G, Asfaw I, Rosenberg J, Loh J, Hoschner J, Miller P (1983) Combined modality therapy for esophageal squamous cell carcinoma. Cancer 51: 1062–1071

    Article  PubMed  CAS  Google Scholar 

  42. Fujimaki M, Soga J, Kanagushi M, Maeda M, Sasaki K, Tanaka O, Muto T (1975) Role of preoperative administration of bleomycin and radiation in the treatment of esophageal cancer. Jpn J Surg 5: 48–52

    Article  Google Scholar 

  43. Gignoux M, Bosset JF, Apoli B, Gillet M, Triboulet JP, 011ivier JM, Roussel A, Segol Ph, Samama G, Tiret E, Mantion G, Borel B (1989) Surgical treatment and combined therapies for esophageal carcinoma. Ann Chir 43: 269–274

    PubMed  CAS  Google Scholar 

  44. Gisselbrecht C, Calco F, Mignot L, Pujade E, Bouvry M, Daune O, Belpomme D, Marty M (1983) Fluorouracil, adriamycin and cisplatin: Combination chemotherapy of advanced esophageal carcinoma. Cancer 52: 974–977

    Article  PubMed  CAS  Google Scholar 

  45. Gisselbrecht C, Gayet B, Maylin C, Rifai M, Espie M, Mignet L, Marty M, Fekete F (1986) Chemotherapy-radiotherapy versus control group in advanced esophageal carcinoma. Proc Am Soc Clin Oncol 5:86, Abstr. 335

    Google Scholar 

  46. Herskovic A, Leichman L, Lattin P, Han I, Ahmad K, Leichman G, Rosenberg J, Steiger Z, Bendal C, White B, Seydel G, Seydsadr M, Vaitkevicius V (1988) Chemo/ radiation with and without surgery in the thoracic esophagus: the Wayne State experience. Int J Radiation Oncology Biol Phys 15: 655–662

    Article  CAS  Google Scholar 

  47. Hilgenberg AD, Carey RW, Wilkins EW, Choi NC, Mathiesen DJ, Grillo HC (1988) Preoperative chemotherapy, surgical resection, and selective postoperative therapy for squamous cell carcinoma of the esophagus. Ann Thorac Surg 45: 357–363

    Article  PubMed  CAS  Google Scholar 

  48. John MJ, Flam MS, Mowry PA, Podolsky WJ, Xavier AM, Wittlinger PS, Padmanabhan A (1989) Radiotherapy alone and chemoradiation for nonmetastatic esophageal carcinoma. Cancer 63: 2397–2404

    Article  PubMed  CAS  Google Scholar 

  49. Keane TJ, Harwood AR, Elhakim T, Rider WD, Cummings BJ, Ginsberg RJ, Cooper JC (1985) Radical radiation therapy with 5-fluorouracil infusion and mitomycin C for esophageal squamous carcinoma. Radiotherapy and Oncology 4: 205–210

    Article  PubMed  CAS  Google Scholar 

  50. Kelsen DP, Bains M, Cvitkovic E, Goldberg R (1979) Vindesine in the treatment of esophageal carcinoma: a phase II study. Cancer Treat Rep 63: 2019–2021

    PubMed  CAS  Google Scholar 

  51. Kelsen D, Chapman R, Bains M, Heelan R, Dukeman M, Golbey R (1982) Phase II study of methyl-GAG in the treatment of esophageal carcinoma. Cancer Treat Rep 66: 1427–1429

    PubMed  CAS  Google Scholar 

  52. Kelsen D, Heelan R, Coonley C (1983) Clinical and pathological evaluation of response to chemotherapy in patients with esophageal cancer. Am J Clin Oncol 6: 539–546

    PubMed  CAS  Google Scholar 

  53. Kelsen D, Hilaris B, Coonley C, Chapman R, Lesser M, Dukeman M, Heelan R, Bains M (1983) Cisplatin, vindesine and bleomycin in chemotherapy of locoregional and advanced esophageal carcinoma. Am J Med 75: 645–652

    Article  PubMed  CAS  Google Scholar 

  54. Kelsen D, Fein R, Coonley C, Heelan R, Bains M (1986) Cisplatin, vindesine and mitoguazone in the treatment of esophageal cancer. Cancer Treat Rep 70: 255–259

    PubMed  CAS  Google Scholar 

  55. Kelsen DP, Nanus D, Lipperman R, Eisenberger M (1988) Phase II trial of ifosfamide (IFOS) in epidermoid carcinoma of the esophagus (ECE): Unexpectantly severe toxicity. Proc Am Soc Clin Oncol 6:87, Abstr. 340

    Google Scholar 

  56. Kelsen D, Bains M, Burt M, Minsky B, Niedzwiecki D, Smith M, Beitler I, Healtan R (1988) Randomized comparison of preoperative chemotherapy versus radiation in epidermoid esophageal cancer. Proc Am Soc Clin Oncol 7:98, Abstr. 374

    Google Scholar 

  57. Kelsen D, Minsky B, Smith M, Beitler J, Niedwziecki D, Chapman D, Bains M, Burt M, Heelan R, Hilaris B (1990) Preoperative therapy for esophageal cancer: a randomized comparison of chemotherapy versus radiation therapy. J Clin Oncol 8: 1352–1361

    PubMed  CAS  Google Scholar 

  58. Kies M, Rosen S, Chmiel J, Shields T (1987) Cisplatin and infusion of 5-fluorouracil in primary management of squamous esophageal cancer. Proc Am Soc Clin Oncol 6:84, Abstr. 327

    Google Scholar 

  59. Kies M, Rosen S, Tsang T, Shetty R, Schneider P, Wallemark C, Shields T (1987) Cisplatin and 5-fluorouracil in primary management of squamous esophageal cancer. Cancer 60: 2156–2160

    Article  PubMed  CAS  Google Scholar 

  60. Kok T, Splinter T, Verwey J (1987) A phase II study of VP 16–213 and cisplatin in advanced esophageal cancer. Proc Eur Conf Clin Oncol 4:31, Abstr. 115

    Google Scholar 

  61. Kok TC, van der Gaast A (1989) A phase II study of VP 16–213 cisplatin in advanced esophageal cancer. EORTC Symposium Straßburg, 11, November 15–17

    Google Scholar 

  62. Kolaric K, Maricic Z, Dujmovic L et al. (1976) Therapy of advanced esophageal cancer with bleomycin, irradiation and combination bleomycin with irradiation. Tumori 62: 255–262

    PubMed  CAS  Google Scholar 

  63. Kolaric K, Maricic Z, Roth et al. (1977) Adriamycin alone and in combination with radiotherapy in the treatment of inoperable esophageal cancer. Tumori 63: 485–491

    PubMed  CAS  Google Scholar 

  64. Kolaric K, Maricic Z, Roth A et al. (1980) Combination of bleomycin and adriamycin with and without radiation in the treatment of inoperable esophageal cancer. Cancer 45: 2265–2273

    Article  PubMed  CAS  Google Scholar 

  65. Kolaric K, Roth A, Nagy B, Zupanc D, Luetic J, Tometic Z (1987) Combined cisplatinum + radiation antitumor activity in loco regionally advanced esophageal cancer. Proc Eur Conf Clin Oncol 4:35, Abstr. 134

    Google Scholar 

  66. Lackey L, Reagan T, Smith A, Anderson WJ (1989) Neoadjuvant therapy of squamous cell carcinoma of the esophagus: role of resection and benefits in partial responders. Ann Thorax Surg 48: 218–221

    Article  CAS  Google Scholar 

  67. Lehr L, Rupp N, Siewert JR (1988) Assessment of resectability of esophageal cancer by computed tomography and magnetic resonance imaging. Surgery 103: 344–350

    PubMed  CAS  Google Scholar 

  68. Leichmann L, Steiger Z, Seydel L, Dindogru A, Kinzie J, Tobin S, Mackenzie G, Shell J (1984) Preoperative chemothrapy and radiation therapy for patients with cancer of the esophagus: a potentially curative approach. J Clin Oncol 2: 120–124

    Google Scholar 

  69. Leichmann L, Herskovic A, Leichmann CG, Lattin PB, Steiger Z, Tapazoglu E, Rosenberg JC, Arbulu A, Asfaw I, Kinzie J (1987) Nonoperative therapy for squamous cell cancer of the esophagus. J Clin Oncol 3: 365–370

    Google Scholar 

  70. Lokich J, Shea M, Chaffey J (1987) Sequential infusional 5-fluorouracil followed by concomitant radiation for tumors of the esophagus and gastroesophageal junction. Cancer 60: 275–279

    Article  PubMed  CAS  Google Scholar 

  71. Lovett D, Kelsen D, Heelan R, Buckley M, Murray P, Evans L (1990) 5Fluorouracil (F) and alpha interferon (IFN) in the treatment of esophageal carcinoma (EC). Proc Am Soc Clin Oncol 9:121, Abstr. 471

    Google Scholar 

  72. Marcial V, Velez-Garzia E, Cintron J et al. (1980) Radiotherapy preceded by multi-drug chemotherapy in carcinoma of the esophagus. Cancer Clin Trials 3: 127–130

    PubMed  CAS  Google Scholar 

  73. Marcuello E, Sanchez M, Piera J (1987) Cisplatinum and bleomycin infusion followed by radiotherapy in patients with locoregional squamous cell esophageal carcinoma. Proc Eur Conf Clin Oncol 3:34, Abstr. 128

    Google Scholar 

  74. Marcuello E, Alba E, Gomes de Segura G, Sanchez Parra M, De Andres L, Lopez Pousa A, Pallares C, Germa J, Lopez J (1988) Cisplatinum and intravenous continuous infusion of bleomycin in advanced and metastatic esophageal cancer. Eur J Cancer Clin Oncol 24: 633–635

    CAS  Google Scholar 

  75. Miller A, Hoogstraten B, Staquet M, Winkler A (1981) Reporting results of cancer treatment. Cancer 47: 207–214

    Article  PubMed  CAS  Google Scholar 

  76. Miller JJ, McIntyre B, Hatcher CR (1985) Combined treatment approach in surgical management of carcinoma of the esophagus: A preliminary report. Ann Thorax Surg 40: 289–293

    Article  CAS  Google Scholar 

  77. Moertel C, Schutt A, Reitemeier R (1976) Therapy for gastrointestinal cancer with the nitrosoureas alone and in drug combination. Cancer Treat Rep 60: 729–732

    PubMed  CAS  Google Scholar 

  78. Nasca S, Coninx P, Segal S, Brossel R, Boulenger E, Cattan A (1980) Phase II study of cisplatin in esophageal squamous cell carcinoma. Cancer Immunol Immunother 5:36, Abstr 143

    Google Scholar 

  79. Orube A, Massuti B, Ciria J, Berdejo C, Garmendia J, Goytan L (1987) Sequential combined therapy of squamous cell carcinoma of the esophagus. Proc Eur Conf Clin Oncol 4:31, Abstr 116

    Google Scholar 

  80. Panettiere F, Leichmann L, O’Bryan R, Haas Ch, Fletcher E (1981) Cisplatinum II, an effective agent in the treatment of epidermoid carcinoma of the esophagus. Cancer Clin Trials 4: 29–31

    PubMed  CAS  Google Scholar 

  81. Panettiere FJ, Leichmann LP, Tilchen EJ, Chen TT (1984) Chemotherapy for advanced epidermoid carcinoma of the esophagus with single-agent cisplatin: final report on a southwest oncology group study. Cancer Treat Rep 68: 1023–1024

    PubMed  CAS  Google Scholar 

  82. Parker EF, Marks RD, Kratz JM, Kratz J, Chaikouni A, Warrent T, Bartels D (1985) Chemoradiation therapy and resection for carcinoma of the esophagus: short term results. Ann Thorac Surg 40: 121–125

    Article  PubMed  CAS  Google Scholar 

  83. Popkin J, Brauer R, Bryne R (1983) Continuous 48-hour infusion of vindesine in squamous cell carcinoma of the upper aero-digestive tract. Proc 13th International Cancer Congress p 40

    Google Scholar 

  84. Poplin E, Fleming Th, Leichmann L, Seydel HG, Steiger Z, Taylor S, Vance R, Stuckey WJ, Rivkin SE (1987) Combined therapies for squamous cell carcinoma of esophagus. A Southwest Oncology Group Study (SWOG-8037). J Clin Oncol 5: 522–628

    Google Scholar 

  85. Preusser P, Wilke H, Achterrath W, Pircher W, Meyer J, Blum M, Bünte H (1987) Esophageal cancer: combination chemotherapy with cisplatin, etoposide, 5fluorouracil in extensive stage of disease. Proc Eur Conf Clin Oncol 4:35, Abstr 131

    Google Scholar 

  86. Preusser P, Wilke A, Achterrath W, Pircher W, Meyer J, Blum M, Lenaz L, Bünte H (1988) Disease oriented phase II study with cisplatin, etoposid and 5-FU (PEF) in advanced squamous cell carcinoma of the esophagus. Proc Am Soc Clin Oncol 7:101, Abstr 388

    Google Scholar 

  87. Queißer W, Preusser P, Mross KB, Fritze D, Rieche K, Beyer J-H, Achterrath W, Edler L (1990) Phase II evaluation of carboplatin in advanced esophageal carcinoma. Onkologie 13: 190–193

    Article  PubMed  Google Scholar 

  88. Radice P, Bunn P, Ihde D (1979) Therapeutic trials with Vp-16 and VM-26. Cancer Treat Rep 63: 1231–1239

    PubMed  CAS  Google Scholar 

  89. Ravry M, Moertel C, Schutt A, Hahn R, Reitemeier R (1973) Treatment of advanced squamous cell carcinoma of the gastrointestinal tract with bleomycin. Cancer Chemother Rep 57: 493–495

    PubMed  CAS  Google Scholar 

  90. Ravry M, Moore M, Omura G, Esseese J, Bartolucci A (1985) Phase II evaluation of cisplatin in squamous carcinoma of the esophagus: a Southeastern Cancer Study Group Trial. Cancer Treat Rep 69: 1457–1458

    PubMed  CAS  Google Scholar 

  91. Resbeut M, Le Prise Fleury E, Ben-Hassel M, Goudier M, Morice-Rouxel M, Douillard J, Chenal Ch (1985) Squamous cell carcinoma of the esophagus: Treatment by combined vincristine - methotrexate plus folinic acid rescue and cisplatin before radiotherapy. Cancer 56: 1246–1250

    Article  PubMed  CAS  Google Scholar 

  92. Richmond J, Seydel HG, Bae Y, Lewis J, Burdakin J, Jacobsen G (1987) Comparison of three treatment strategies for esophageal cancer within a single institution. Int J Radiation Oncol Biol Phys 13: 1617–1620

    Article  CAS  Google Scholar 

  93. Roth J, Pass H, Flanagan M, Graeber G, Rosenberg J, Wesley R (1985) Randomized trial of pre-and postoperative cisplatin, vindesine and bleomycin chemotherapy in epidermoid carcinoma of the esophagus. In: Joji Ishigami (ed) Recent advances in chemotherapy. University of Tokyo Press, pp 1158–1159

    Google Scholar 

  94. Roth JA, Pass H, Flanagan MM, Graeber GM, Rosenberg JC, Steinberg S (1988) Randomized clinical trial of preoperative and postoperative adjuvant chemotherapy with cisplatin, vindesine, and bleomycin for carcinoma of the esophagus. J Thorac Cardiovasc Surg 96: 242–248

    PubMed  CAS  Google Scholar 

  95. Roussel A, Bleiberg H, Dalesio O, Jacob JH, Haegele P, Jung GM, Palliot B, Heinitz JF, Gignoux M, Nasca S, Namer A, Buyse M, Duez N (1989) Palliative therapy of inoperable esophageal carcinoma with radiotherapy and methotrexate: final results of a controlled clinical trial. Int J Radiation Oncol Biol Phys 16: 67–72

    Article  CAS  Google Scholar 

  96. Saikia TK, Advani SH, Ramakrishan G, Swaroop S, Sharma S, Desai B (1989) Intermediate-dose methotrexate and cisplatin in the treatment of advanced epidermoid esophageal carcinoma. Cancer 64: 371–373

    Article  PubMed  CAS  Google Scholar 

  97. Schlag P, Herrmann R, Raeth U, Lehner B, Schwarz V, Herfarth Ch (1987) Präoperative Chemotherapie beim Oesophaguskarzinom: Vorteile oder Gefahr für den chirurgischen Eingriff. Langenbecks Arch Chir 372: 155–160

    Article  PubMed  CAS  Google Scholar 

  98. Schlag P, Lehner B, Herrmann R, Raeth V, Schwarz V, Herfarth Ch (1988) Feasability and impact of preoperative chemotherapy in patients with esophageal cancer. Proc Am Soc Clin Oncol 7:116, Abst 448

    Google Scholar 

  99. Schlag R, Herrmann R, Raeth U, Schwarz V, Herfarth C (1988) Preoperative (neoadjuvant) chemotherapy in squamous cell cancer of the esophagus. Springer, Berlin Heidelberg (Recent Results in Cancer Research 110: 14–20

    Article  PubMed  CAS  Google Scholar 

  100. Seitz JF, Giovanni M, Pedaut-Cesana J, Fuentes P, Giudicelli R, Gauthier AP, Carcassonne Y (1990) Inoperable nonmetastatic squamous cell carcinoma of the esophagus managed by concomitant chemotherapy (5-fluorouracil and cisplatin) and radiation therapy. Cancer 66: 214–219

    Article  PubMed  CAS  Google Scholar 

  101. Siewert JR, Roder JD (1987) Chirurgische Therapie des Plattenepithelkarzinoms des Oesophagus–erweiterte Radikalität. Langenbecks Arch Chir 371: 129–139

    Article  Google Scholar 

  102. Siewert JR (1988) Leistungen der Tumorchirurgie bei Tumoren der Speiseröhre. Langenbecks Arch Chir 372: 119–126

    Google Scholar 

  103. Siewert JR, Roder JD, Fink U (1990) Fortschritte in der chirurgischen Behandlung des Plattenepithelkarzinoms der Speiseröhre. Internist 31: 131–142

    PubMed  CAS  Google Scholar 

  104. Spielmann M, Guillot T, Kac J, Cvitkovic E, Rougier P, Le Chevalier T, Kayitalire L, Tursz T (1989) Phase II trial of cisplatin and continuous infusion of bleomycin and fluorouracil in advanced esophageal cancer. Proc Am Soc Clin Oncol 8:102, Abstr 393

    Google Scholar 

  105. Steiger Z, Franklin R, Wilson R (1981) Eradication and palliation of squamous cell carcinoma of the esophagus with chemotherapy, radiotherapy and surgical therapy. J Thorac Cardiovasc Surg 82: 713–719

    PubMed  CAS  Google Scholar 

  106. Stephens F (1973) Bleomycin–a new approach in cancer chemotherapy. Med J Aust 1: 1277–1283

    PubMed  CAS  Google Scholar 

  107. Sternberg C, Kelsen D, Dukeman M, Leichman L, Heelan R (1985) Carboplatin: a new platinum analog in the treatment of epidermoid carcinoma of the esophagus. Cancer Treat Rep 69: 1305–1307

    PubMed  CAS  Google Scholar 

  108. Stewart FM, Harkins BJ, Hahn SS, Daniel TM (1989) Cisplatin, 5-fluorouracil, mitomycin C and concurrent radiation therapy with and without esophagectomy for esophageal carcinoma. Cancer 64: 622–628

    Article  PubMed  CAS  Google Scholar 

  109. Strack M, Wadler S, Lyver A, Wietnik P (1990) Phase II trial of fluorouracil (5FU) and recombinant alpha-2a-interferon (rIFN 2a) in patients (pts) with advanced carcinoma of the esophagus. Proc Am Soc Clin Oncol 9:119, Abstr 462

    Google Scholar 

  110. Tancini G, Bajetta E, Bonadonna G (1974) Terapia con bleomycin da sola o in associazione con methotrexate nel carcinoma epidermoide dell’esofago. Tumori 60: 65–71

    PubMed  CAS  Google Scholar 

  111. Tapazoglou E, Kish J, Ensley J, Al-Sarraf M (1986) The activity of a single-agent 5fluorouracil infusion in advanced and recurrent head and neck cancer. Cancer 57: 1105–1109

    Article  PubMed  CAS  Google Scholar 

  112. Tosch U, Wendt TG, Rohloff R, Willich N (1988) Simultane Radio-Chemotherapie beim Plattenepithelkarzinom des Oesophagus. Strahlenther Onkol 164: 214–218

    PubMed  CAS  Google Scholar 

  113. Vogl S, Greenwald E, Kaplan B (1981) Effective chemotherapy for esophageal cancer with methotrexate, bleomycin and cis-diamminedichloroplatinum II. Cancer 48: 2555–2558

    Article  PubMed  CAS  Google Scholar 

  114. Vogl SE, Camocho F, Berenzweig M, Ruckdeschel J (1985) Chemotherapy for esophageal cancer with mitoguazone, methotrexate, bleomycin and cisplatin. Cancer Treat Rep 69: 21–23

    PubMed  CAS  Google Scholar 

  115. Walker SJ, Steel A, Edwards C, Cullen MH, Matthews HR (1990) Assessment of the response to chemotherapy in esophageal carcinoma. Br J Surg 77: A692

    Google Scholar 

  116. Wendt TG, Hartenstein RC, Willich N (1989) Simultane Radio-Chemotherapie bei fortgeschrittenen Oesophaguskarzinomen. Int Conference on Combined Radio-Chemotherapy (RCT), Rothenburg o.d.T., 21–24th June

    Google Scholar 

  117. Werner ID (1979) The multi-disciplinary approach in the treatment of squamous carcinoma of the esophagus: The Groote Schuur Hospital Experience. Front Gastroint Res 5: 130–133

    CAS  Google Scholar 

  118. Whittington R, Close H (1979) Clinical experience with mitomycin C. Cancer Chemother Rep 54: 195–198

    Google Scholar 

  119. Yagoda A, Mukher JI, Joung C (1972) Bleomycin, an antitumor antibiotic: clinical experience in 274 patients. Ann Intern Med 77: 861–870

    PubMed  CAS  Google Scholar 

  120. Zaniboni A, Ferrar V, Montini E, Marpicati P, Simoncini E, Garni F, Pezzola D, Tancini G, Marini G (1987) Cisplatin, high dose folinic acid and 5-fluorouracil for squamous cell carcinoma of the esophagus - preliminary results. Proc Eur Conf Clin Oncol 4: 36

    Google Scholar 

Download references

Authors
  1. U. Fink
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Pfeiffer
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Gossmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H. Wilke
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. P. Preusser
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. P. Lukas
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. J. R. Siewert
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Abteilung Hämatologie und Onkologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Str. 8, 3000, Hannover 61, Deutschland

    Hans-Joachim Schmoll

  2. Klinik für Abdominal- und Transplantationschirurgie, Zentrum Chirurgie der Medizinischen Hochschule Hannover, Konstanty-Gutschow-Str. 8, 3000, Hannover 61, Deutschland

    Hans-Joachim Meyer  & Rudolf Pichlmayr  & 

  3. Westdeutsches Tumorzentrum Essen, Innere Klinik und Poliklinik, Hufelandstr. 55, 4300, Essen 1, Deutschland

    Hansjochen Wilke

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Fink, U. et al. (1992). Chemotherapie des Plattenepithelkarzinoms der Speiseröhre im interdisziplinären Konzept. In: Schmoll, HJ., Meyer, HJ., Wilke, H., Pichlmayr, R. (eds) Aktuelle Therapie gastrointestinaler Tumoren. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76187-4_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-76187-4_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76188-1

  • Online ISBN: 978-3-642-76187-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation