Abstract
Brain edema is a major cause of morbidity and mortality in patients with severe head injury. Anesthetic agents, which often have to be administered in these patients for diagnostic or operative procedures, usually decrease cerebral metabolism [7]. On the other hand, inhalation anesthetics may increase cerebral blood flow (CBF) by vasodilation of brain vessels [1]. Therefore, anesthesia may either protect the injured brain by reduction of metabolism, or contribute to the spread of brain edema by cerebral hyperemia. To date, little information is available about the effect of anesthetic agents in traumatized brain. We therefore carried out experimental investigations to analyze the influence of isoflurane, fentanyl, thiopental, and α-chloralose on regional cerebral blood flow (rCBF) and formation of brain edema from a focal injury to the brain.
Supported by the Deutsche Forschungsgemeinschaft grant Ba 452/6–7
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© 1991 Springer-Verlag Berlin Heidelberg
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Murr, R., Schürer, L., Berger, S., Enzenbach, R., Baethmann, A. (1991). Effects of Anesthetic Agents on Brain Edema and Cerebral Blood Flow from a Focal Cold Lesion in Rabbit Brain. In: Bock, W.J., Lumenta, C., Brock, M., Klinger, M. (eds) Intracranial Angiomas Neurosurgical Intensive Care Supratentorial Tumors in Children. Advances in Neurosurgery, vol 19. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76182-9_5
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DOI: https://doi.org/10.1007/978-3-642-76182-9_5
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-53311-5
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