Skip to main content

Zusammenfassung

Der Tränenweg besteht aus drei Schichten: einer äußeren Lipidschicht, einer mittleren wäßrigen Schicht und einer inneren Muzinschicht. Von den zahlreichen, das Auge umgebenden Drüsen trägt eine jede zur Bildung des Tränenfilms bei. Die Meibom-Drüsen und in geringerem Maße die Zeis- und Moll-Drüsen sondern die Lipide der äußeren Schicht ab. Die Tränendrüse bildet zusammen mit den akzessorischen Tränendrüsen (Krause- und Wolfring-Drüsen) die mittlere wäßrige Schicht. Becherzellen und bis zu einem gewissen Grad die Henle-Krypten und die Manz-Drüsen sondern die innere Schleimschicht ab. Dieses Kapitel wird vor allem aüf zwei Aspekte der Tränenerzeugung eingehen: die neurokrine Regulation und den sekretorischen Zellmechanismus.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 49.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Jones LT (1966) The lacrimal tear system and its treatment. Am J Ophthalmol 62: 47–60

    PubMed  CAS  Google Scholar 

  2. Jordan A, Baum J (1980) Basic tear flow: Does it exist? Ophthalmology 87: 920–930

    PubMed  CAS  Google Scholar 

  3. Botelho SY, Hisada M, Fuenmayor N (1966) Functional innervation of the lacrimal gland in the cat. Arch Ophthalmol 76: 581–588

    PubMed  CAS  Google Scholar 

  4. Brown SI, Dervichian DG (1969) The oils of the meibomian glands Arch Ophthalmol 82: 537–540

    CAS  Google Scholar 

  5. Gilbard JP, Rossi SR, Heyda KG, Dartt DA (1990) Stimulation of tear secretion by topical agents that increase cyclic nucleotide levels. Invest Ophthalmol Vis Sci 31: 1381–1388

    PubMed  CAS  Google Scholar 

  6. Aragona P, Candela V, Caputi AP, Micali A, Puzzolo D, Quintieri M (1987) Effects of a stable analogue of PGE2 (ll-deoxy-13,14-didehydro-16(S)-methylester PGE2: FCE 20700) on the secretory processes of conjunctival goblet cells of rabbit. Exp Eye Res 45: 647–654

    Article  PubMed  CAS  Google Scholar 

  7. Dartt DA (1989) Signal transduction and control of lacrimal gland protein secretion: a review. Curr Eye Res 8: 619–636

    Article  PubMed  CAS  Google Scholar 

  8. Kelly RB (1985) Pathways of protein secretion in eukaryotes. Science 230: 25–32

    Article  PubMed  CAS  Google Scholar 

  9. Nikkinen A, Lehtosalo JI, Uusital H, Palkama A, Panula P (1984) The lacrimal glands of the rat and guinea pig are innervated by nerve fibers containing immunoreactivities for substance P and vasoactive intestinal peptide. Histochemistry 81: 23–27

    Article  PubMed  CAS  Google Scholar 

  10. Lehtosalo J, Uusitalo H, Mahrberg T, Panula P, Palkama A (1989) Nerve fibers showing immunoreactivities for proenkephalin A-derived peptides in the lacrimal glands of the guinea pig. Graefes Arch Clin Exp Ophthalmol 227: 455–458

    Article  PubMed  CAS  Google Scholar 

  11. Jahn R, Padel U, Porsch P-H, Soling H-D (1982) Adrenocorticotropic hormone and α-melanocyte-stimulating hormone induce secretion and protein phosphorylation in the rat lacrimal gland by activation of a cAMP-dependent pathway. Eur J Biochem 126: 623–629

    Article  PubMed  CAS  Google Scholar 

  12. Sullivan DA (1987) Endocrine control of the ocular secretory immune system. In: Berczi I, Kovacs K (eds) Hormones and immunity. MTP Press, Lancaster, England, pp 54–92

    Google Scholar 

  13. Berridge MJ, Irvine RF (1989) Inositol trisphosphate, a novel second messenger in cellular signal transuction. Nature 312: 315–321

    Article  Google Scholar 

  14. Smith WL (1989) The eicosanoids and their biochemical mechanisms of action. Biochem J 259: 315–324

    PubMed  CAS  Google Scholar 

  15. Berridge MJ (1985) The molecular basis of communication within the cell. Sci Am 253: 142–152

    Article  PubMed  CAS  Google Scholar 

  16. Dartt DA, Møller M, Poulsen JH (1981) Lacrimal gland electrolyte and water secretion in the rabbit: Localization and role of (Na+ + K+)-activated ATPase. J Physiol 321: 557–569

    Google Scholar 

  17. Lechleiter JD, Dartt DA, Brehm P (1988) Vasoactive intestinal peptide activates Ca2+- dependent K+ channels through a cAMP pathway in mouse lacrimal cells. Neuron 1: 227–235

    Article  PubMed  CAS  Google Scholar 

  18. Mircheff AK (1989) Lacrimal fluid and electrolyte secretion: A review. Curr Eye Res 8: 607–617

    Article  PubMed  CAS  Google Scholar 

  19. Dawidowicz EA (1987) Dynamics of membrane lipid metabolism and turnover. Annu Rev Biochem 56: 43–61

    Article  PubMed  CAS  Google Scholar 

  20. Alexander JH, van Lennep EW, Young JA (1972) Water and electrolyte secretion by the exorbital lacrimal gland of the rat studied by micropuncture and catheterization techniques. Pflugers Arch 337: 299–309

    Article  PubMed  CAS  Google Scholar 

  21. Botelho SY, Martinez EV, Pholpramool C, van Prooyen HC, Janssen JT, De Palau A (1976) Modification of stimulated lacrimal gland flow by sympathetic nerve impulses in rabbit. Am J Physiol 230: 80–84

    PubMed  CAS  Google Scholar 

  22. Ichikawa A, Nakajima Y (1962) Electron microscope study on the lacrimal gland of the rat. Tohoku J, Exp Med 77: 136–149

    Google Scholar 

  23. Gilbard JP, Dartt DA, Rood RP, Rossi SR, Gray KL, Donowitz M (1988) Increased tear secretion in pancreatic cholera: a newly recognized symptom in an experiment of nature. Am J Med 85: 552–554

    Article  PubMed  CAS  Google Scholar 

  24. Tangkrisanavinont V (1984) Adrenergic control of lacrimal secretion in rabbits. Life Sei 34: 2373–2378

    Article  CAS  Google Scholar 

  25. Pholpramool C (1979) Secretory effect of prostaglandins on the rabbit lacrimal gland in vivo. Prostaglandins in Medicine 3: 185–192

    Article  CAS  Google Scholar 

  26. Gripps MM, Bennett DJ (1990) Peptidergic stimulation and inhibition of lacrimal gland adenylate cyclase. Invest Ophthalmol Vis Sei 31: 2145–2150

    Google Scholar 

  27. Gilbard JP, Dartt DA (1982) Changes in rabbit lacrimal gland fluid osmolality with flow rate. Invest Ophthalmol Vis Sei 23: 804–806

    CAS  Google Scholar 

  28. Dartt DA, Shulman M, Gray KL, Rossi SR, Matkin C, Gilbard JP (1988) Stimulation of rabbit lacrimal gland secretion with biologically active peptides. Am J Physiol 254: G300–G306

    PubMed  CAS  Google Scholar 

  29. Kelleher RS, Hann LE, Edwards JE, Sullivan DA (1990) Endocrine, neural and immune control of secretory component output by lacrimal acinar cells. (Submitted for publication )

    Google Scholar 

  30. Allansmith MR, Kajiyama G, Abelson MB, Simon MA (1976) Plasma cell content of main and accessory lacrimal glands and conjunctiva. Am J Ophthalmol 82: 819–826

    PubMed  CAS  Google Scholar 

  31. Vigneswaran N, Wilk CM, Heese A, Hornstein OP, Naumann GOH (1990) Immuno-histochemical characterization of epithelial cells. I. Normal major and accessory lacrimal glands. Graefes Arch Clin Exp Ophthalmol 228: 58–64

    Article  PubMed  CAS  Google Scholar 

  32. Gillette TE, Allansmith MR, Greiner JV, Janusz M (1980) Histologic and immunohi-stologic comparison of main and accessory lacrimal tissue. Am J Ophthalmol 89: 724–730

    PubMed  CAS  Google Scholar 

  33. Ruskell GL (1985) Innervation of the conjunctiva. Trans Ophtahlmol Soc UK 104: 390–395

    Google Scholar 

  34. Tseng SCG, Hirst LW, Farazdaghi M, Green WR (1984) Goblet cell density and vascularization during conjunctival transdifferentiation. Invest Ophthalmol Vis Sei 25: 1168–1176

    CAS  Google Scholar 

  35. Neutra MR, Phillips TL, Phillips TE (1984) Regulation of intestinal globet cells in situ, in mucosal explants and in the isolated epithelium. Ciba Found Symp 109: 20–39

    PubMed  CAS  Google Scholar 

  36. Seidler U, Sewing K-Fr (1989) Ca2+-dependent and —independent secretagogue action on gastric mucus secretion in rabbit mucosal explants. Am J Physiol 256: G739–G746

    Google Scholar 

  37. Boat TE, Cheng PW, Klinger JD, Liedtke CM, Tandler B (1984) Proteinase release mucin from airways goblet cells. Ciba Found Symp 109: 72–88

    PubMed  CAS  Google Scholar 

  38. Woodward DF, Hawley SB, Williams LS, Ralston TR, Protzman CE, Spada CS, Nieves AL (1990) Studies on the ocular pharmacology of prostaglandin D2. Invest Ophthalmol Vis Sei 31: 138–146

    CAS  Google Scholar 

  39. Tiffany JM (1985) The role of meibomian secretion in the tears. Trans Ophthalmol Soc UK 104: 396–401

    PubMed  Google Scholar 

  40. Baron C, Blough HA (1976) Composition of the neutral lipids of bovine meibomian secretions. J Lipid Res 17: 373–376

    PubMed  CAS  Google Scholar 

  41. Tiffany JM (1978) Individual variations in human meibomian lipid composition. Exp Eye Res 27: 289–300

    Article  PubMed  CAS  Google Scholar 

  42. Parakkal PF, Matoltsy AG (1964) The five structures of the lipid droplets in the meibomian gland of the mouse. J Ultrastruc Res 10: 417–421

    Article  CAS  Google Scholar 

  43. Linton RG, Curaow DH, Riley WJ (1961) The meibomian glands: An investigation into the secretion and some aspects of the physiology. Br J Ophthalmol 45: 718–723

    Article  PubMed  CAS  Google Scholar 

  44. Miraglia T, Gomes NF (1969) The meibomian glands of the marmoset ( Callithrix jachus ). Acta Anat 74: 104–113

    Google Scholar 

  45. Montagna W, Ellis RA (1959) Cholingeric innervation of the meiboinian gland. Anat Ree 135: 121–128

    Article  CAS  Google Scholar 

  46. Klyce SD, Crosson CE (1985) Transport processes across the rabbit corneal epithelium: a review. Curr Eye Res 4: 323–331

    Article  PubMed  CAS  Google Scholar 

  47. Maurice DM (1973) Electrical potential and ion transport across the conjunctiva. Exp Eye Res 15: 527–532

    Article  PubMed  CAS  Google Scholar 

  48. Abelson MB, Smith LM (1991) Mediators of ocular inflammation. In: Duane TD, Jaeger EA (eds) Biomedical foundations of ophthalmology. Harper & Row, Philadelphia, chap 27

    Google Scholar 

  49. Greiner JV, Weidman TA, Korb DR, Allansmith MR (1985) Histochemical analysis of secretory vesicles in non-goblet conjunctival epithelial cells. Acta Ophthalmol 63: 89–92

    CAS  Google Scholar 

  50. Gilbard JP, Rossi SR, Heyda KG, Dartt DA (1991) Stimulation of tear secretion and treatment of dry eye with 3-isobutyl-l-methylxanthine. Arch Ophthalmol

    Google Scholar 

  51. Ariga H, Edwards J, Sullivan DA (1989) Androgen control of autoimmune expression in lacrimal glands of MRL/Mp-lpr/lpr mice. Clin Immunol Immunopathol 53: 499–508

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Dartt, D.A. (1991). Physiologie der Tränenerzeugung. In: Marquardt, R., Lemp, M.A. (eds) Das trockene Auge in Klinik und Praxis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76181-2_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-76181-2_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53307-8

  • Online ISBN: 978-3-642-76181-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics